Human IL-10 R▀ Antibody | R&D Systems MAB874-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-10 R▀ Antibody

catalog :

MAB874-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

90220

reactivity :

human

application :

western blot, immunohistochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 9

Reference
Yuan Q, Fan Z, Huang W, Huo X, Yang X, Ran Y, et al. Human cytomegalovirus UL23 exploits PD-L1 inhibitory signaling pathway to evade T cell-mediated cytotoxicity. MBio. 2024;15:e0119124 pubmed publisher
Chang C, Liu C, Pan S, Huang W, Peng C, Hsu H. Targeting of interleukin-10 receptor by a potential human interleukin-10 peptide efficiently blocks interleukin-10 pathway-dependent cell proliferation. Tzu Chi Med J. 2020;32:245-253 pubmed publisher
Obajemu A, Rao N, Dilley K, Vargas J, Sheikh F, Donnelly R, et al. IFN-Î»4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling. J Immunol. 2017;199:3808-3820 pubmed publisher
Hong M, Schwerk J, Lim C, Kell A, Jarret A, Pangallo J, et al. Interferon lambda 4 expression is suppressed by the host during viral infection. J Exp Med. 2016;213:2539-2552 pubmed
Kelly A, Robinson M, Roche G, Biron C, O Farrelly C, Ryan E. Immune Cell Profiling of IFN-? Response Shows pDCs Express Highest Level of IFN-?R1 and Are Directly Responsive via the JAK-STAT Pathway. J Interferon Cytokine Res. 2016;36:671-680 pubmed
Onabajo O, Porter Gill P, Paquin A, Rao N, Liu L, Tang W, et al. Expression of Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells. J Interferon Cytokine Res. 2015;35:888-900 pubmed publisher
Akil H, Abbaci A, LallouÃ© F, Bessette B, Costes L, Domballe L, et al. IL22/IL-22R pathway induces cell survival in human glioblastoma cells. PLoS ONE. 2015;10:e0119872 pubmed publisher
Gruber S, Gloria Luciani M, Grundtner P, Zdanov A, Gasche C. Differential signaling of cmvIL-10 through common variants of the IL-10 receptor 1. Eur J Immunol. 2008;38:3365-75 pubmed publisher
Jenkins C, Garcia W, Godwin M, Spencer J, Stern J, Abendroth A, et al. Immunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection. J Virol. 2008;82:3736-50 pubmed publisher

product information

master code :

MAB874

SKU :

MAB874-100

product name :

Human IL-10 R▀ Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human IL-10 Rß Antibody from R&D Systems is a mouse monoclonal antibody to IL-10 R beta. This antibody reacts with human. The Human IL-10 Rß Antibody has been validated for the following applications: Neutralization,Western Blot,Flow Cytometry,Immunohistochemistry,CyTOF-ready.

target :

IL-10 R beta

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

90220

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-10 R▀, Met20-Ser220, Accession # Q08334

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-10 R▀ in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-10 R alpha , rhIFN-gamma RI, and rhIFN-gamma R2 is observed.

gene symbol :

IL10RB

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

IL-10 Inhibition of IL-1ss secre-tion and Neutralization by Human IL-10 Rss Antibody.

accessionNumbers :

Q08334

applications :

Western Blot,Neutralization,Flow Cytometry,Immunohistochemistry,CyTOF-ready

USD :

489 USD

alt names :

CDw210b, CDw210b antigen, CRF2-4IL-10R subunit 2, CRFB4, CRFB4human transmembrane receptor protein; cytokine receptor10CDW210B, D21S58, D21S66, IBD25, IL-10 receptor subunit beta, IL10R beta, IL-10R2, IL-10R2IL-10R subunit beta, IL10RB, IL-10RB, interleukin 10 receptor, beta, Interleukin-10 receptor subunit 2, interleukin-10 receptor subunit beta, member 4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage