IL-18 R alpha/IL-1 R5 Antibody | R&D Systems MAB840-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

IL-18 R alpha/IL-1 R5 Antibody

catalog :

MAB840-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

70625

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 12

Reference
Lin L, Wang J, Liu D, Liu S, Xu H, Ji N, et al. Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma. Sci Rep. 2016;6:26757 pubmed publisher
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, et al. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015;21:820-6 pubmed publisher
Pesce S, Carlomagno S, Moretta A, Sivori S, Marcenaro E. Uptake of CCR7 by KIR2DS4âº NK cells is induced upon recognition of certain HLA-C alleles. J Immunol Res. 2015;2015:754373 pubmed publisher
Horbelt D, Boergermann J, Chaikuad A, Alfano I, Williams E, Lukonin I, et al. Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation. J Biol Chem. 2015;290:3390-404 pubmed publisher
Guo W, Miyoshi K, Dubner R, Gu M, Li M, Liu J, et al. Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade. Mol Pain. 2014;10:35 pubmed publisher
Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, et al. Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLoS ONE. 2013;8:e82586 pubmed publisher
Blom L, Poulsen L. IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures. J Immunol. 2012;189:4331-7 pubmed publisher
Takei S, Hoshino T, Matsunaga K, Sakazaki Y, Sawada M, Oda H, et al. Soluble interleukin-18 receptor complex is a novel biomarker in rheumatoid arthritis. Arthritis Res Ther. 2011;13:R52 pubmed publisher
Tucci M, Quatraro C, Lombardi L, Pellegrino C, Dammacco F, Silvestris F. Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18. Arthritis Rheum. 2008;58:251-62 pubmed publisher
Rao D, Tracey K, Pober J. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response. J Immunol. 2007;179:6536-46 pubmed
Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, et al. CD molecules 2006--human cell differentiation molecules. J Immunol Methods. 2007;319:1-5 pubmed
Ebert E, Mehta V. Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell Immunol. 2006;241:7-13 pubmed

image

image 1 :

IFN-? Secretion Induced by IL-18/IL-1F4 and Neutrali-zation by IL-18 Ra/IL-1 R5 Antibody.

product information

brand :

R&D Systems, a Bio-Techne Brand

catalog number base :

MAB840

SKU :

MAB840-100

product name :

IL-18 R alpha/IL-1 R5 Antibody

Description :

The Human IL-18 R alpha/IL-1 R5 Antibody from R&D Systems is a mouse monoclonal antibody to IL-18R alpha/IL-1 R5. This antibody reacts with human. The Human IL-18 R alpha/IL-1 R5 Antibody has been validated for the following applications: Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, CyTOF-ready.

target :

IL-18 R alpha/IL-1 R5

category :

Primary Antibodies

unit size :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

70625

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-18 R alpha/IL-1 R5, Glu20-Arg329, Accession # Q13478

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects Recombinant Human IL-18 R alpha/IL-1 R5 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) IL-1 RI, rhIL-1 RII, rhIL-1 R3, rhIL-1 R4, rhIL-1 R6, rhIL-1 R7, rhIL-1 R8, rhIL-1 R9, rhSIGIRR or recombinant mouse IL-18 R alpha is observed.

gene symbol :

IL18R1

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

Q13478

applications :

Flow Cytometry, Immunohistochemistry, Neutralization, Immunocytochemistry, CyTOF-ready

USD :

459 USD

alt names :

CD218a, CD218a;CDw218a;IL18R1;IL18RA;IL-18Ralpha;IL-18R-alpha;IL18Ralpha2;IL1RRP;IL-1Rrp;Interleukin-18 receptor 1, IL-1 R5, IL-1 Rrp, IL-18 R1, IL18R alpha, IL18R1, IL-18Ra

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage