product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat Bcl-2 Antibody
catalog :
MAB8272
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
625509
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry
more info or order :
citations: 12
Reference
Liu B, Xu J, Lu L, Gao L, Zhu S, Sui Y, et al. Metformin induces pyroptosis in leptin receptor-defective hepatocytes via overactivation of the AMPK axis. Cell Death Dis. 2023;14:82 pubmed publisher
Wang H, Ba T, Wang Q, Yang L, Li C, Hao X, et al. Human Umbilical Cord Mesenchymal Stem Cells Attenuate Severe Burn-Induced Multiple Organ Injury via Potentiating IGF-1 and BCL-2/BAX Pathway. Stem Cells Int. 2022;2022:5474289 pubmed publisher
Hira K, Sharma P, Mahale A, Prakash Kulkarni O, Sajeli Begum A. Cyclo(Val-Pro) and Cyclo(Leu-Hydroxy-Pro) from Pseudomonas sp. (ABS-36) alleviates acute and chronic renal injury under in vitro and in vivo models (Ischemic reperfusion and unilateral ureter obstruction). Int Immunopharmacol. 2022;103:108494 pubmed publisher
Rahaman M, Banik S, Akter M, Rahman M, Sikder M, Hosokawa T, et al. Curcumin alleviates arsenic-induced toxicity in PC12 cells via modulating autophagy/apoptosis. Ecotoxicol Environ Saf. 2020;200:110756 pubmed publisher
Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, et al. Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways. Front Pharmacol. 2019;10:163 pubmed publisher
Sharma A, Bandyopadhayaya S, Chowdhury K, Sharma T, Maheshwari R, Das A, et al. Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells. PLoS ONE. 2019;14:e0209435 pubmed publisher
Shan Y, Sun S, Yang F, Shang N, Liu H. Dexmedetomidine protects the developing rat brain against the neurotoxicity wrought by sevoflurane: role of autophagy and Drp1-Bax signaling. Drug Des Devel Ther. 2018;12:3617-3624 pubmed publisher
Torres A, Arriagada V, Erices J, Toro M, Rocha J, Niechi I, et al. FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells. Int J Mol Sci. 2018;19: pubmed publisher
Wang X, Zhao Y, Sun L, Shi Y, Li Z, Zhao X, et al. Exosomes derived from human umbilical cord mesenchymal stem cells improve myocardial repair via upregulation of Smad7. Int J Mol Med. 2018;41:3063-3072 pubmed publisher
He W, Xu Y, Zhang C, Lü J, Li J, Xiang D, et al. Hepatoprotective effect of calculus bovis sativus on nonalcoholic fatty liver disease in mice by inhibiting oxidative stress and apoptosis of hepatocytes. Drug Des Devel Ther. 2017;11:3449-3460 pubmed publisher
Liu C, Zhao Z, Chen Z, Che C, Zou Z, Wu X, et al. DL-3-n-butylphthalide protects endothelial cells against advanced glycation end product-induced injury by attenuating oxidative stress and inflammation responses. Exp Ther Med. 2017;14:2241-2248 pubmed publisher
Galinato M, Orio L, Mandyam C. Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience. 2015;286:97-108 pubmed publisher
product information
master code :
MAB8272
SKU :
MAB8272
product name :
Human/Mouse/Rat Bcl-2 Antibody
unit size :
100 ug (also 25 ug)
description :
The Human/Mouse/Rat Bcl-2 Antibody from R&D Systems is a mouse monoclonal antibody to Bcl-2. This antibody reacts with human,mouse,rat. The Human/Mouse/Rat Bcl-2 Antibody has been validated for the following applications: Western Blot,Cell Culture,Immunohistochemistry,Knockout Validated.
target :
Bcl-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
625509
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant human Bcl-2, Ala2-Asp211, Accession # P10415
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat
specificity :
Detects human Bcl-2 in direct ELISAs and Western blots. In direct ELISAs, approximately 25-40% cross-reactivity with recombinant mouse (rm) Bcl-2 is observed and no cross-reactivity with recombinant human BCL2L12 is observed. In Western blots, 100% cross-reactivity with rmBcl-2 is observed.
gene symbol :
BCL2
Antibody validation :
Knockout/Knockdown
top caption :
Detection of Human, Mouse, and Rat Bcl-2 antibody by Western Blot.
accessionNumbers :
P10415
applications :
Western Blot,Cell Culture,Immunohistochemistry,Knockout Validated
USD :
479 USD
alt names :
apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl2, Bcl-2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.