Human uPAR Antibody | R&D Systems MAB807-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human uPAR Antibody

catalog :

MAB807-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

62022

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 20

Reference
McNamee N, de la Fuente L, Santos Martinez M, O Driscoll L. Proteomics profiling identifies extracellular vesicles' cargo associated with tumour cell induced platelet aggregation. BMC Cancer. 2022;22:1023 pubmed publisher
Mukherjee K, Gu C, Collins A, Mettlen M, Samelko B, Altintas M, et al. Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury. Nat Commun. 2022;13:2422 pubmed publisher
Sharma S, Watanabe T, Nishimoto T, Takihara T, Mlakar L, Nguyen X, et al. E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects. JCI Insight. 2021;6: pubmed publisher
Abraham A, Xu Y, Roem J, Greenberg J, Weidemann D, Sabbisetti V, et al. Variability in CKD Biomarker Studies: Soluble Urokinase Plasminogen Activator Receptor (suPAR) and Kidney Disease Progression in the Chronic Kidney Disease in Children (CKiD) Study. Kidney Med. 2021;3:712-721.e1 pubmed publisher
Guo H, Wang F, Diao Y, Zhang Z, Chen Q, Qian C, et al. Knockdown of Notch1 inhibits nasopharyngeal carcinoma cell growth and metastasis via downregulation of CCL2, CXCL16, and uPA. Mol Carcinog. 2019;: pubmed publisher
van Veen M, Matas Rico E, van de Wetering K, Leyton Puig D, Kedziora K, De Lorenzi V, et al. Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. elife. 2017;6: pubmed publisher
Al Taweel F, Douglas C, Whawell S. The Periodontal Pathogen Porphyromonas gingivalis Preferentially Interacts with Oral Epithelial Cells in S Phase of the Cell Cycle. Infect Immun. 2016;84:1966-1974 pubmed publisher
Gilder A, Jones K, Hu J, Wang L, Chen C, Carter B, et al. Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion. J Biol Chem. 2015;290:14798-809 pubmed publisher
Arumugam T, Deng D, Bover L, Wang H, Logsdon C, Ramachandran V. New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice. Mol Cancer Ther. 2015;14:941-51 pubmed publisher
Kacsinta A, Rubenstein C, Sroka I, Pawar S, Gard J, Nagle R, et al. Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines. Biochem Biophys Res Commun. 2014;454:335-40 pubmed publisher
Huang J, Liu G, Zhang Y, Cui Z, Wang F, Liu X, et al. Urinary soluble urokinase receptor levels are elevated and pathogenic in patients with primary focal segmental glomerulosclerosis. BMC Med. 2014;12:81 pubmed publisher
Tersteeg C, de Maat S, De Meyer S, Smeets M, Barendrecht A, Roest M, et al. Plasmin cleavage of von Willebrand factor as an emergency bypass for ADAMTS13 deficiency in thrombotic microangiopathy. Circulation. 2014;129:1320-31 pubmed publisher
Sroka I, Sandoval C, Chopra H, Gard J, Pawar S, Cress A. Macrophage-dependent cleavage of the laminin receptor α6β1 in prostate cancer. Mol Cancer Res. 2011;9:1319-28 pubmed publisher
Taherian A, Li X, Liu Y, Haas T. Differences in integrin expression and signaling within human breast cancer cells. BMC Cancer. 2011;11:293 pubmed publisher
Vergiliana J, Asokananthan N, Stewart G. Activation of the plasma kallikrein-kinin system on human lung epithelial cells. Biol Chem. 2010;391:1067-77 pubmed publisher
Hu H, Kwun J, Aizenstein B, Knechtle S. Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation. 2009;87:1814-20 pubmed publisher
Schnickmann S, Camacho Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, et al. AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor. J Invest Dermatol. 2009;129:1140-8 pubmed publisher
Gonzalez R, Seurynck Servoss S, Crowley S, Brown M, Omenn G, Hayes D, et al. Development and validation of sandwich ELISA microarrays with minimal assay interference. J Proteome Res. 2008;7:2406-14 pubmed publisher
Brooks A, Bates M, Vrtis R, Jarjour N, Bertics P, Sedgwick J. Urokinase-type plasminogen activator modulates airway eosinophil adhesion in asthma. Am J Respir Cell Mol Biol. 2006;35:503-11 pubmed
Spijkers P, da Costa Martins P, Westein E, Gahmberg C, Zwaginga J, Lenting P. LDL-receptor-related protein regulates beta2-integrin-mediated leukocyte adhesion. Blood. 2005;105:170-7 pubmed

product information

master code :

MAB807

SKU :

MAB807-100

product name :

Human uPAR Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human uPAR Antibody from R&D Systems is a mouse monoclonal antibody to uPAR. This antibody reacts with human. The Human uPAR Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Antibody Array Development,ELISA Microarray Development,Immunoprecipitation,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Blockade of Receptor-ligand Interaction,ELISA Capture (Matched Antibody Pair),CyTOF-ready.

target :

uPAR

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

62022

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human uPAR, Leu23-Arg303, Accession # Q03405

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human uPAR in direct ELISAs and Western blots. When used in a sandwich ELISA in combination with the biotinylated anti-human uPAR detection antibody (Catalog # BAF807), no significant cross-reactivity was observed with recombinant mouse uPAR.

gene symbol :

PLAUR

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of uPAR antibody in Human Blood Granulocytes antibody by Flow Cytometry.

accessionNumbers :

Q03405

applications :

Flow Cytometry,Western Blot,Antibody Array Development,ELISA Microarray Development,Immunoprecipitation,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Blockade of Receptor-ligand Interaction,ELISA Capture (Matched Antibody Pair),CyTOF-ready

USD :

489 USD

alt names :

CD87, CD87 antigen, Monocyte activation antigen Mo3, plasminogen activator, urokinase receptor, PLAUR, uPAR, U-PAR, UPARurokinase plasminogen activator surface receptor, u-plasminogen activator receptor form 2, URKRMO3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage