Human Osteoprotegerin/TNFRSF11B Antibody | R&D Systems MAB805-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Osteoprotegerin/TNFRSF11B Antibody

catalog :

MAB805-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

439 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

69146

reactivity :

human

application :

western blot, immunohistochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 10

Reference
Chatzidionysiou K, Circiumaru A, Rethi B, Joshua V, Engstrom M, Hensvold A, et al. Tocilizumab decreases T cells but not macrophages in the synovium of patients with rheumatoid arthritis while it increases the levels of serum interleukin-6 and RANKL. RMD Open. 2021;7: pubmed publisher
McLane J, Ligon L. Stiffened Extracellular Matrix and Signaling from Stromal Fibroblasts via Osteoprotegerin Regulate Tumor Cell Invasion in a 3-D Tumor in Situ Model. Cancer Microenviron. 2016;9:127-139 pubmed publisher
Jiao K, Niu L, Li Q, Chen F, Zhao W, Li J, et al. Biphasic silica/apatite co-mineralized collagen scaffolds stimulate osteogenesis and inhibit RANKL-mediated osteoclastogenesis. Acta Biomater. 2015;19:23-32 pubmed publisher
Revu S, Neregård P, af Klint E, Korotkova M, Catrina A. Synovial membrane immunohistology in early-untreated rheumatoid arthritis reveals high expression of catabolic bone markers that is modulated by methotrexate. Arthritis Res Ther. 2013;15:R205 pubmed
Funck Brentano T, Lin H, Hay E, Ah Kioon M, Schiltz C, Hannouche D, et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS ONE. 2012;7:e33543 pubmed publisher
Zinonos I, Labrinidis A, Lee M, Liapis V, Hay S, Ponomarev V, et al. Anticancer efficacy of Apo2L/TRAIL is retained in the presence of high and biologically active concentrations of osteoprotegerin in vivo. J Bone Miner Res. 2011;26:630-43 pubmed publisher
Locklin R, Federici E, Espina B, Hulley P, Russell R, Edwards C. Selective targeting of death receptor 5 circumvents resistance of MG-63 osteosarcoma cells to TRAIL-induced apoptosis. Mol Cancer Ther. 2007;6:3219-28 pubmed
Makrygiannakis D, af Klint E, Catrina S, Botusan I, Klareskog E, Klareskog L, et al. Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis. Arthritis Rheum. 2006;54:1463-72 pubmed
Fonseca J, Cortez Dias N, Francisco A, Sobral M, Canhao H, Resende C, et al. Inflammatory cell infiltrate and RANKL/OPG expression in rheumatoid synovium: comparison with other inflammatory arthropathies and correlation with outcome. Clin Exp Rheumatol. 2005;23:185-92 pubmed
Mandelin J, Li T, Hukkanen M, Liljeström M, Salo J, Santavirta S, et al. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J Rheumatol. 2005;32:713-20 pubmed

product information

master code :

MAB805

SKU :

MAB805-100

product name :

Human Osteoprotegerin/TNFRSF11B Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human Osteoprotegerin/TNFRSF11B Antibody from R&D Systems is a mouse monoclonal antibody to Osteoprotegerin/TNFRSF11B. This antibody reacts with human. The Human Osteoprotegerin/TNFRSF11B Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry.

target :

Osteoprotegerin/TNFRSF11B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

69146

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Osteoprotegerin/TNFRSF11B, Glu22-Leu401, Accession # AAB53709

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human Osteoprotegerin/TNFRSF11B in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse Osteoprotegerin is observed.

gene symbol :

TNFRSF11B

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Osteoprotegerin/TNFRSF11B Inhibition of TRAIL/ TNFSF10-induced Cyto-toxicity and Neutral-ization by Human Osteoprotegerin/ TNFRSF11B Antibody.

accessionNumbers :

AAB53709

applications :

Western Blot,Neutralization,Immunohistochemistry

USD :

439 USD

alt names :

OCIF, OCIFMGC29565, OPG, OPGtumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, TR1, tumor necrosis factor receptor superfamily, member 11b

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage