Human/Mouse/Rat GDF-11/GDF-8 Antibody | R&D Systems MAB788-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat GDF-11/GDF-8 Antibody

catalog :

MAB788-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

84214

reactivity :

human, mouse, rat

application :

western blot

more info or order :

R&D Systems product webpage

citations: 12

Reference
Samant S, Pillai V, Gupta M. Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets. JCSM Rapid Commun. 2021;4:40-56 pubmed publisher
Liu J, Pan M, Huang D, Guo Y, Yang M, Zhang W, et al. Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus. Cells. 2020;9: pubmed publisher
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler J, et al. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. JCI Insight. 2020;5: pubmed publisher
Samant S, Kanwal A, Pillai V, Bao R, Gupta M. The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. Sci Rep. 2017;7:11877 pubmed publisher
Miroshnychenko O, Chang W, Dragoo J. The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration. Am J Sports Med. 2017;45:945-953 pubmed publisher
Lee S, Kim J, Jin D, Jin H, Kim Y. Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide. Comp Biochem Physiol B Biochem Mol Biol. 2016;194-195:65-70 pubmed publisher
Lawlor M, Viola M, Meng H, Edelstein R, Liu F, Yan K, et al. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. Am J Pathol. 2014;184:1831-42 pubmed publisher
Lawlor M, Read B, Edelstein R, Yang N, Pierson C, Stein M, et al. Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. Am J Pathol. 2011;178:784-93 pubmed publisher
Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, et al. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. Am J Physiol Cell Physiol. 2010;298:C465-76 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Sato F, Kurokawa M, Yamauchi N, Hattori M. Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA. Am J Physiol Cell Physiol. 2006;291:C538-45 pubmed

product information

master code :

MAB788

SKU :

MAB788-100

product name :

Human/Mouse/Rat GDF-11/GDF-8 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human/Mouse/Rat GDF-11/GDF-8 Antibody from R&D Systems is a rat monoclonal antibody to GDF-11/GDF-8. This antibody reacts with avian - chicken,human,mouse,rat,transgenic mouse,fish - paralichthys olivaceus (olive flounder or japanese flatfish). The Human/Mouse/Rat GDF-11/GDF-8 Antibody has been validated for the following applications: Western Blot,ELISA Development.

target :

GDF-11/GDF-8

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

84214

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse GDF-8, Asn25-Ser376, Accession # O08689

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Avian - Chicken,Human,Mouse,Rat,Fish - Paralichthys olivaceus (Olive Flounder or Japanese flatfish)

specificity :

Detects human, mouse, and rat GDF-8 in direct ELISAs and Western blots. In Western blots, this antibody shows approximately 30% cross-reactivity with recombinant human/mouse/rat GDF-11. In direct ELISAs, this antibody shows less than 1% cross-reactivity with recombinant mouse (rm) GDF-1, rmGDF-3, rmGDF-5, rmGDF-6, and rmGDF-9.

gene symbol :

GDF11

accessionNumbers :

O08689

applications :

ELISA Development,Western Blot

USD :

469 USD

alt names :

BMP11, BMP-11, bone morphogenetic protein 11, GDF11, GDF-11, GDF8, growth/differentiation factor 11, MSLHP, MSTN, Myostatin, VHO

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage