product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat GDF-11/GDF-8 Antibody
catalog :
MAB788-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
84214
reactivity :
human, mouse, rat
application :
western blot
more info or order :
citations: 12
Reference
Samant S, Pillai V, Gupta M. Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets. JCSM Rapid Commun. 2021;4:40-56 pubmed publisher
Liu J, Pan M, Huang D, Guo Y, Yang M, Zhang W, et al. Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus. Cells. 2020;9: pubmed publisher
Pan C, Jaiswal Agrawal N, Zulia Y, Singh S, Sha K, Mohler J, et al. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia. JCI Insight. 2020;5: pubmed publisher
Samant S, Kanwal A, Pillai V, Bao R, Gupta M. The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. Sci Rep. 2017;7:11877 pubmed publisher
Miroshnychenko O, Chang W, Dragoo J. The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration. Am J Sports Med. 2017;45:945-953 pubmed publisher
Lee S, Kim J, Jin D, Jin H, Kim Y. Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide. Comp Biochem Physiol B Biochem Mol Biol. 2016;194-195:65-70 pubmed publisher
Lawlor M, Viola M, Meng H, Edelstein R, Liu F, Yan K, et al. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice. Am J Pathol. 2014;184:1831-42 pubmed publisher
Lawlor M, Read B, Edelstein R, Yang N, Pierson C, Stein M, et al. Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. Am J Pathol. 2011;178:784-93 pubmed publisher
Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, et al. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. Am J Physiol Cell Physiol. 2010;298:C465-76 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Sengle G, Charbonneau N, Ono R, Sasaki T, Alvarez J, Keene D, et al. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008;283:13874-88 pubmed publisher
Sato F, Kurokawa M, Yamauchi N, Hattori M. Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA. Am J Physiol Cell Physiol. 2006;291:C538-45 pubmed
product information
master code :
MAB788
SKU :
MAB788-100
product name :
Human/Mouse/Rat GDF-11/GDF-8 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human/Mouse/Rat GDF-11/GDF-8 Antibody from R&D Systems is a rat monoclonal antibody to GDF-11/GDF-8. This antibody reacts with avian - chicken,human,mouse,rat,transgenic mouse,fish - paralichthys olivaceus (olive flounder or japanese flatfish). The Human/Mouse/Rat GDF-11/GDF-8 Antibody has been validated for the following applications: Western Blot,ELISA Development.
target :
GDF-11/GDF-8
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
84214
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse GDF-8, Asn25-Ser376, Accession # O08689
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Avian - Chicken,Human,Mouse,Rat,Fish - Paralichthys olivaceus (Olive Flounder or Japanese flatfish)
specificity :
Detects human, mouse, and rat GDF-8 in direct ELISAs and Western blots. In Western blots, this antibody shows approximately 30% cross-reactivity with recombinant human/mouse/rat GDF-11. In direct ELISAs, this antibody shows less than 1% cross-reactivity with recombinant mouse (rm) GDF-1, rmGDF-3, rmGDF-5, rmGDF-6, and rmGDF-9.
gene symbol :
GDF11
accessionNumbers :
O08689
applications :
ELISA Development,Western Blot
USD :
469 USD
alt names :
BMP11, BMP-11, bone morphogenetic protein 11, GDF11, GDF-11, GDF8, growth/differentiation factor 11, MSLHP, MSTN, Myostatin, VHO
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.