Human/Mouse Orexin A/Hypocretin-1 Antibody | R&D Systems MAB763-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse Orexin A/Hypocretin-1 Antibody

catalog :

MAB763-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

97505

reactivity :

human, mouse, rat, dogs

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 19

Reference
B xe1 rez L xf3 pez S, Mecawi A, Bryan N, Pau x17e a A, Duque V, Gillard B, et al. Translational and Posttranslational Dynamics in a Model Peptidergic System. Mol Cell Proteomics. 2023;22:100544 pubmed publisher
Zhou F, Wang D, Li H, Wang S, Zhang X, Li A, et al. Orexinergic innervations at GABAergic neurons of the lateral habenula mediates the anesthetic potency of sevoflurane. CNS Neurosci Ther. 2023;29:1332-1344 pubmed publisher
Smiley J, Bleiwas C, Canals Baker S, Williams S, SEARS R, Teixeira C, et al. Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals. Alcohol. 2021;97:1-11 pubmed publisher
Reitz S, Wasilczuk A, Beh G, Proekt A, Kelz M. Activation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness. Curr Biol. 2021;31:394-405.e4 pubmed publisher
Liu D, Li J, Wu J, Dai J, Chen X, Huang Y, et al. Monochromatic Blue Light Activates Suprachiasmatic Nucleus Neuronal Activity and Promotes Arousal in Mice Under Sevoflurane Anesthesia. Front Neural Circuits. 2020;14:55 pubmed publisher
Amodeo L, Liu W, Wills D, Vetreno R, Crews F, Ehlers C. Adolescent alcohol exposure increases orexin-A/hypocretin-1 in the anterior hypothalamus. Alcohol. 2020;88:65-72 pubmed publisher
Naidoo N, Zhu J, Galante R, Lian J, Strus E, Lee A, et al. Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior. Neurobiol Aging. 2018;69:10-25 pubmed publisher
Ogawa K, Suga H, Ozone C, Sakakibara M, Yamada T, Kano M, et al. Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors. Sci Rep. 2018;8:3615 pubmed publisher
Liguori G, Squillacioti C, Assisi L, Pelagalli A, Vittoria A, Costagliola A, et al. Potential role of orexin A binding the receptor 1 for orexins in normal and cryptorchid dogs. BMC Vet Res. 2018;14:55 pubmed publisher
Liguori G, Squillacioti C, Assisi L, Mirabella N, Langella E, Costagliola A, et al. Localization of orexin B and receptor 2 for orexins in testicular cytotypes of the camelid alpaca (Vicugna pacos). Reprod Domest Anim. 2017;52:452-458 pubmed publisher
Sears R, Fink A, Wigestrand M, Farb C, de Lecea L, LeDoux J. Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proc Natl Acad Sci U S A. 2013;110:20260-5 pubmed publisher
Deutschman C, Raj N, McGuire E, Kelz M. Orexinergic activity modulates altered vital signs and pituitary hormone secretion in experimental sepsis. Crit Care Med. 2013;41:e368-75 pubmed publisher
Panossian L, Fenik P, Zhu Y, Zhan G, McBurney M, Veasey S. SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J Neurosci. 2011;31:4025-36 pubmed publisher
Naidoo N, Zhu J, Zhu Y, Fenik P, Lian J, Galante R, et al. Endoplasmic reticulum stress in wake-active neurons progresses with aging. Aging Cell. 2011;10:640-9 pubmed publisher
Plaza Zabala A, Martín García E, de Lecea L, Maldonado R, Berrendero F. Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. J Neurosci. 2010;30:2300-10 pubmed publisher
Zhao T, Szabo N, Ma J, Luo L, Zhou X, Alvarez Bolado G. Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus. Eur J Neurosci. 2008;28:1941-55 pubmed publisher
Kelz M, Sun Y, Chen J, Cheng Meng Q, Moore J, Veasey S, et al. An essential role for orexins in emergence from general anesthesia. Proc Natl Acad Sci U S A. 2008;105:1309-14 pubmed publisher
Chen L, Thakkar M, Winston S, Bolortuya Y, Basheer R, McCarley R. REM sleep changes in rats induced by siRNA-mediated orexin knockdown. Eur J Neurosci. 2006;24:2039-48 pubmed
Georgescu D, Zachariou V, Barrot M, Mieda M, Willie J, Eisch A, et al. Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci. 2003;23:3106-11 pubmed

product information

master code :

MAB763

SKU :

MAB763-100

product name :

Human/Mouse Orexin A/Hypocretin-1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human/Mouse Orexin A/Hypocretin-1 Antibody from R&D Systems is a mouse monoclonal antibody to Orexin A/Hypocretin-1. This antibody reacts with canine,human,mouse,rat,transgenic mouse,camelid - vicugna pacos (alpaca). The Human/Mouse Orexin A/Hypocretin-1 Antibody has been validated for the following applications: Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Orexin A/Hypocretin-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

97505

conjugate :

Unconjugated

host :

Mouse

immunogen :

KLH-coupled human Orexin A/Hypocretin-1 synthetic peptide, Accession # O43612

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Canine,Human,Mouse,Rat,Camelid - Vicugna pacos (Alpaca)

specificity :

Detects human and mouse Orexin A/Hypocretin-1. In dot blots, no cross-reactivity with recombinant human Orexin B is observed.

gene symbol :

HCRT

accessionNumbers :

O43612

applications :

Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

489 USD

alt names :

HCRT, Hcrt1, hypocretin (orexin) neuropeptide precursor, Hypocretin1, Hypocretin-1, NRCLP1, orexin, OXHcrt, PPORX, PPOXHypocretin

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage