Mouse CCL20/MIP-3 alpha Antibody | R&D Systems MAB7601-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CCL20/MIP-3 alpha Antibody

catalog :

MAB7601-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

114908

reactivity :

human, mouse, rat

application :

ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 15

Reference
B xe9 nard A, Mittelst xe4 dt A, Kl xf6 sch B, Glanz K, M xfc ller J, Schoen J, et al. IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils. Cell Rep. 2023;42:112637 pubmed publisher
Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven B, et al. Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses. Nat Commun. 2023;14:663 pubmed publisher
Bruchard M, Geindreau M, Perrichet A, Truntzer C, Ballot E, Boidot R, et al. Recruitment and activation of type 3 innate lymphoid cells promote antitumor immune responses. Nat Immunol. 2022;23:262-274 pubmed publisher
Yu M, Pal S, Paterson C, Li J, Tyagi A, Adams J, et al. Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells. J Clin Invest. 2021;131: pubmed publisher
Shin J, Kwon M, Hwang J, Lee S, Lee J, Kim H, et al. Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation. Cell Death Dis. 2020;11:301 pubmed publisher
Yu M, Malik Tyagi A, Li J, Adams J, Denning T, Weitzmann M, et al. PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells. Nat Commun. 2020;11:468 pubmed publisher
Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3. Cell Physiol Biochem. 2017;42:1961-1972 pubmed publisher
Krebs C, Paust H, Krohn S, Koyro T, Brix S, Riedel J, et al. Autoimmune Renal Disease Is Exacerbated by S1P-Receptor-1-Dependent Intestinal Th17 Cell Migration to the Kidney. Immunity. 2016;45:1078-1092 pubmed publisher
Boyle S, Faulkner J, McColl S, Kochetkova M. The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages. Mol Cancer. 2015;14:115 pubmed publisher
Mabuchi T, Singh T, Takekoshi T, Jia G, Wu X, Kao M, et al. CCR6 is required for epidermal trafficking of Î³Î´-T cells in an IL-23-induced model of psoriasiform dermatitis. J Invest Dermatol. 2013;133:164-71 pubmed publisher
Nanjappa S, Heninger E, WÃ¼thrich M, Gasper D, Klein B. Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog. 2012;8:e1002771 pubmed publisher
Kallal L, Schaller M, Lindell D, Lira S, Lukacs N. CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC. Eur J Immunol. 2010;40:1042-52 pubmed publisher
Cruickshank S, deSchoolmeester M, Svensson M, Howell G, Bazakou A, Logunova L, et al. Rapid dendritic cell mobilization to the large intestinal epithelium is associated with resistance to Trichuris muris infection. J Immunol. 2009;182:3055-62 pubmed publisher
Muranski P, Boni A, Antony P, Cassard L, Irvine K, Kaiser A, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112:362-73 pubmed publisher
Wen H, Hogaboam C, Lukacs N, Cook D, Lira S, Kunkel S. The chemokine receptor CCR6 is an important component of the innate immune response. Eur J Immunol. 2007;37:2487-98 pubmed

product information

master code :

MAB7601

SKU :

MAB7601-100

product name :

Mouse CCL20/MIP-3 alpha Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse CCL20/MIP-3 alpha Antibody from R&D Systems is a rat monoclonal antibody to CCL20/MIP-3 alpha. This antibody reacts with mouse,rat. The Mouse CCL20/MIP-3 alpha Antibody has been validated for the following applications: Bioassay,ELISA Development,ELISA Development (Capture),Neutralization,In vivo assay,ELISA Capture (Matched Antibody Pair).

target :

CCL20/MIP-3 alpha

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

114908

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse CCL20/MIP-3 alpha , Ala28-Met97, Accession # O89093

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse,Rat

specificity :

Detects mouse CCL20/MIP-3 alpha in ELISAs. Does not cross-react with recombinant human (rh) CCL19, rhCCL20, recombinant mouse (rm) CCL3, 4, 9, 19, rmCXCL2, or recombinant rat CCL20.

gene symbol :

CCL20

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Chemotaxis Induced by CCL20/MIP-3a and Neutralization by Mouse CCL20/MIP-3a Antibody.

accessionNumbers :

O89093

applications :

Bioassay,ELISA Development,ELISA Development (Capture),Neutralization,In vivo assay,ELISA Capture (Matched Antibody Pair)

USD :

459 USD

alt names :

beta chemokine exodus-1, Beta-chemokine exodus-1, CC chemokine LARC, C-C motif chemokine 20, chemokine (C-C motif) ligand 20, CKb4, exodus-1, LARC, LARCLiver and activation-regulated chemokine, MIP3 alpha, MIP-3 alpha, MIP-3a, MIP-3-alpha, MIP3AMacrophage inflammatory protein 3 alpha, SCYA20Small-inducible cytokine A20, small inducible cytokine subfamily A (Cys-Cys), member 20, ST38

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage