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company name :
R&D Systems
product type :
antibody
product name :
NLRP3/NALP3 Antibody
catalog :
MAB7578
quantity :
100 ug (also 25 ug)
price :
453 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
768319
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
citations: 33
Reference
La Rosa F, Zoia C, Bazzini C, Bolognini A, Saresella M, Conti E, et al. Modulation of MAPK- and PI3/AKT-Dependent Autophagy Signaling by Stavudine (D4T) in PBMC of Alzheimer's Disease Patients. Cells. 2022;11: pubmed publisher
Park E, Kim S, Yao D, Savarraj J, Choi H, Chen P, et al. Soluble Endoglin Stimulates Inflammatory and Angiogenic Responses in Microglia That Are Associated with Endothelial Dysfunction. Int J Mol Sci. 2022;23: pubmed publisher
Soung A, Davé V, Garber C, Tycksen E, Vollmer L, Klein R. IL-1 reprogramming of adult neural stem cells limits neurocognitive recovery after viral encephalitis by maintaining a proinflammatory state. Brain Behav Immun. 2022;99:383-396 pubmed publisher
Zhang Y, Hou B, Liang P, Lu X, Wu Y, Zhang X, et al. TRPV1 channel mediates NLRP3 inflammasome-dependent neuroinflammation in microglia. Cell Death Dis. 2021;12:1159 pubmed publisher
Ma N, Wei Z, Hu J, Gu W, Ci X. Farrerol Ameliorated Cisplatin-Induced Chronic Kidney Disease Through Mitophagy Induction via Nrf2/PINK1 Pathway. Front Pharmacol. 2021;12:768700 pubmed publisher
Baral A, Park P. Leptin Induces Apoptotic and Pyroptotic Cell Death via NLRP3 Inflammasome Activation in Rat Hepatocytes. Int J Mol Sci. 2021;22: pubmed publisher
Croden J, Silva J, Huang W, Gupta N, Fu W, Matovinovic K, et al. Cyanidin-3-O-Glucoside improves the viability of human islet cells treated with amylin or Aβ1-42 in vitro. PLoS ONE. 2021;16:e0258208 pubmed publisher
Wang Y, Chen S, Yang P, Chen J, Kong W, Wang Y. AIM2 inflammasome activation may mediate high mobility group box 1 release in murine allergic rhinitis. Braz J Otorhinolaryngol. 2021;: pubmed publisher
Deng Z, Lin Z, Zhong Q, Lu M, Fang H, Liu J, et al. Interleukin 1 beta-induced chloride currents are important in osteoarthritis onset: an in vitro study. Acta Biochim Biophys Sin (Shanghai). 2021;53:400-409 pubmed publisher
Oliveira A, Pereira M, Belew A, Ferreira L, Pereira L, Neves E, et al. Gene expression network analyses during infection with virulent and avirulent Trypanosoma cruzi strains unveil a role for fibroblasts in neutrophil recruitment and activation. PLoS Pathog. 2020;16:e1008781 pubmed publisher
Serini S, Guarino R, Ottes Vasconcelos R, Celleno L, Calviello G. The Combination of Sulforaphane and Fernblock® XP Improves Individual Beneficial Effects in Normal and Neoplastic Human Skin Cell Lines. Nutrients. 2020;12: pubmed publisher
Hou B, Zhang Y, Liang P, He Y, Peng B, Liu W, et al. Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype. Cell Death Dis. 2020;11:377 pubmed publisher
Lecoeur H, Prina E, Rosazza T, Kokou K, N Diaye P, Aulner N, et al. Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response. Cell Rep. 2020;30:1870-1882.e4 pubmed publisher
Ferreira N, Bruder Nascimento T, Pereira C, Zanotto C, Prado D, Silva J, et al. NLRP3 Inflammasome and Mineralocorticoid Receptors Are Associated with Vascular Dysfunction in Type 2 Diabetes Mellitus. Cells. 2019;8: pubmed publisher
Chang C, Shih H, Huang I, Tsai P, Chen K, Huang C. Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats. Int J Mol Sci. 2019;20: pubmed publisher
Samir P, Kesavardhana S, Patmore D, Gingras S, Malireddi R, Karki R, et al. DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome. Nature. 2019;573:590-594 pubmed publisher
Serini S, Cassano R, Facchinetti E, Amendola G, Trombino S, Calviello G. Anti-Irritant and Anti-Inflammatory Effects of DHA Encapsulated in Resveratrol-Based Solid Lipid Nanoparticles in Human Keratinocytes. Nutrients. 2019;11: pubmed publisher
Lancaster G, Langley K, Berglund N, Kammoun H, Reibe S, Estevez E, et al. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism. Cell Metab. 2018;27:1096-1110.e5 pubmed publisher
Boursereau R, Abou Samra M, Lecompte S, Noel L, Brichard S. Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy. BMC Biol. 2018;16:33 pubmed publisher
Gugliandolo A, Giacoppo S, Ficicchia M, Aliquò A, Bramanti P, Mazzon E. Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation. Mol Med Rep. 2018;17:6235-6244 pubmed publisher
Gong D, Zhang Y, Chen D, Hong L, Han F, Liu Q, et al. Endothelial GPR124 Exaggerates the Pathogenesis of Atherosclerosis by Activating Inflammation. Cell Physiol Biochem. 2018;45:547-557 pubmed publisher
Kosmidou C, Efstathiou N, Hoang M, Notomi S, Konstantinou E, Hirano M, et al. Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018;8:461 pubmed publisher
DeWolf S, Shigeoka A, Scheinok A, Kasimsetty S, Welch A, McKay D. Expression of TLR2, NOD1, and NOD2 and the NLRP3 Inflammasome in Renal Tubular Epithelial Cells of Male versus Female Mice. Nephron. 2017;137:68-76 pubmed publisher
Yang A, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, et al. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017;127:2829-2841 pubmed publisher
Daley D, Mani V, Mohan N, Akkad N, Pandian G, Savadkar S, et al. NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma. J Exp Med. 2017;214:1711-1724 pubmed publisher
Chen X, Wang N, Zhu Y, Lu Y, Liu X, Zheng J. The Antimalarial Chloroquine Suppresses LPS-Induced NLRP3 Inflammasome Activation and Confers Protection against Murine Endotoxic Shock. Mediators Inflamm. 2017;2017:6543237 pubmed publisher
Bian F, Xiao Y, Zaheer M, Volpe E, Pflugfelder S, Li D, et al. Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017;18: pubmed publisher
Hu Z, Zhang Y, Wang J, Mao P, Lv X, Yuan S, et al. Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. Cell Death Dis. 2016;7:e2468 pubmed publisher
Kim Y, Wang W, Okla M, Kang I, Moreau R, Chung S. Suppression of NLRP3 inflammasome by γ-tocotrienol ameliorates type 2 diabetes. J Lipid Res. 2016;57:66-76 pubmed publisher
Liu X, Hu Z, Zhou B, Li X, Tao R. Chinese Herbal Preparation Xuebijing Potently Inhibits Inflammasome Activation in Hepatocytes and Ameliorates Mouse Liver Ischemia-Reperfusion Injury. PLoS ONE. 2015;10:e0131436 pubmed publisher
Antonopoulos C, Russo H, El Sanadi C, Martin B, Li X, Kaiser W, et al. Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling. J Biol Chem. 2015;290:20167-84 pubmed publisher
Maier N, Leppla S, Moayeri M. The cyclopentenone prostaglandin 15d-PGJ2 inhibits the NLRP1 and NLRP3 inflammasomes. J Immunol. 2015;194:2776-85 pubmed publisher
Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, et al. ASC in renal collecting duct epithelial cells contributes to inflammation and injury after unilateral ureteral obstruction. Am J Pathol. 2014;184:1287-98 pubmed publisher
image
image 1 :
R&D Systems MAB7578 image 1
Detection of Mouse NLRP3/NALP3 antibody by Western Blot.
product information
brand :
R&D Systems
master code :
MAB7578
SKU :
MAB7578
product name :
NLRP3/NALP3 Antibody
description :
The Human/Mouse NLRP3/NALP3 Antibody from R&D Systems is a rat monoclonal antibody to NLRP3/NALP3. This antibody reacts with human, mouse. The Human/Mouse NLRP3/NALP3 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready.
target :
NLRP3/NALP3
category :
Primary Antibodies
unit sizes :
100 ug (also 25 ug)
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
768319
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
E. coli -derived recombinant mouse NLRP3/NALP3, Met1-Arg153, Accession # Q8R4B8
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human, Mouse
specificity :
Detects mouse NLRP3/NALP3 in direct ELISAs. In direct ELISAs, 100% cross-reactivity with recombinant human NLRP3/NALP3 is observed.
gene symbol :
NLRP3
accessionNumbers :
Q8R4B8
applications :
Western Blot, Immunohistochemistry, Intracellular Staining by Flow Cytometry, Immunocytochemistry, CyTOF-ready
USD :
453 USD
alt names :
AGTAVPRL, AII, AII/AVP, Angiotensin/vasopressin receptor AII/AVP-like, AVP, C1orf7, Caterpiller protein 1.1, CIAS1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCAS, FCU, Leucine-rich repeat-, and PYD-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, NACHT, LRR and PYD containing protein 3, NACHT, LRR and PYD domains-containing protein 3, NALP3, NLR family, pyrin domain containing 3, NLRP3, Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3, PYPAF1, PYRIN-containing APAF1-like protein 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.