BMP-4 Antibody | R&D Systems MAB757-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

BMP-4 Antibody

catalog :

MAB757-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

442 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

66119

reactivity :

human

application :

western blot, neutralization

more info or order :

R&D Systems product webpage

citations: 13

Reference
Liu J, Liu Z, Zhang J, Chen X, Chen J, Sui L, et al. Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner. Pharmaceutics. 2022;14: pubmed publisher
Dupays L, Towers N, Wood S, David A, Stuckey D, Mohun T. Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function. PLoS ONE. 2019;14:e0212992 pubmed publisher
Patel A, Vipparthi K, Thatikonda V, Arun I, Bhattacharjee S, Sharan R, et al. A subtype of cancer-associated fibroblasts with lower expression of alpha-smooth muscle actin suppresses stemness through BMP4 in oral carcinoma. Oncogenesis. 2018;7:78 pubmed publisher
Blanchette Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, et al. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. 2018;37:4013-4032 pubmed publisher
Sallon C, Callebaut I, Boulay I, Fontaine J, Logeart Avramoglou D, Henriquet C, et al. Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells. J Biol Chem. 2017;292:15352-15368 pubmed publisher
Herrera B, Inman G. A rapid and sensitive bioassay for the simultaneous measurement of multiple bone morphogenetic proteins. Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum. BMC Cell Biol. 2009;10:20 pubmed publisher
Jeanpierre S, Nicolini F, Kaniewski B, Dumontet C, Rimokh R, Puisieux A, et al. BMP4 regulation of human megakaryocytic differentiation is involved in thrombopoietin signaling. Blood. 2008;112:3154-63 pubmed publisher
Kane R, Godson C, O Brien C. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. Mol Vis. 2008;14:1138-48 pubmed
Zode G, Clark A, Wordinger R. Activation of the BMP canonical signaling pathway in human optic nerve head tissue and isolated optic nerve head astrocytes and lamina cribrosa cells. Invest Ophthalmol Vis Sci. 2007;48:5058-67 pubmed
Fuller M, DeChant A, Rothstein B, Caprariello A, Wang R, Hall A, et al. Bone morphogenetic proteins promote gliosis in demyelinating spinal cord lesions. Ann Neurol. 2007;62:288-300 pubmed
Bleuming S, Kodach L, Garcia Leon M, Richel D, Peppelenbosch M, Reitsma P, et al. Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach. J Pathol. 2006;209:190-7 pubmed
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, et al. BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation. Mol Cell Biol. 2003;23:5664-79 pubmed
van den Brink G, Hardwick J, Tytgat G, Brink M, ten Kate F, van Deventer S, et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology. 2001;121:317-28 pubmed

image

image 1 :

Alkaline Phosphatase Production Induced by BMP-4 and Neutralization by Human BMP-4 Antibody.

product information

brand :

R&D Systems

master code :

MAB757

SKU :

MAB757-100

product name :

BMP-4 Antibody

description :

The Human BMP-4 MAb (Clone 66119) from R&D Systems is a mouse monoclonal antibody to BMP-4. This antibody reacts with human. The Human BMP-4 MAb (Clone 66119) has been validated for the following applications: Western Blot, Neutralization.

target :

BMP-4

category :

Primary Antibodies

sizes available :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

66119

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human BMP-4, Ser293-Arg408, Accession # P12644

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human BMP-4 in direct ELISAs and Western blots

gene symbol :

BMP4

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

P12644

applications :

Western Blot, Neutralization

USD :

442 USD

alt names :

BMP2B, BMP-2B, BMP2B1, BMP2BMCOPS6, BMP4, BMP-4, Bone morphogenetic protein 2B, bone morphogenetic protein 4, DVR4, MCOPS6, OFC11, ZYME

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage