product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human Phospho-Lck (Y394) Antibody
catalog :
MAB7500
quantity :
100 ug (also 25 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
755103
reactivity :
human, mouse
application :
western blot, immunocytochemistry
more info or order :
R&D Systems product webpage
citations: 11
Reference
Zevolini F, Onnis A, Khazen R, M xfc ller S, Marotta G, Valitutti S, et al. Polo-like kinase 1 regulates immune synapse assembly and cytotoxic T cell function by driving microtubule dynamics. J Cell Sci. 2024;137: pubmed publisher
Ye Y, Morita S, Chang J, Buckley P, Wilhelm K, DiMaio D, et al. Allosteric inhibition of the T cell receptor by a designed membrane ligand. elife. 2023;12: pubmed publisher
Dey G, Bharti R, Braley C, Alluri R, Esakov E, Crean Tate K, et al. LCK facilitates DNA damage repair by stabilizing RAD51 and BRCA1 in the nucleus of chemoresistant ovarian cancer. J Ovarian Res. 2023;16:122 pubmed publisher
Saygin C, Giordano G, Shimamoto K, Eisfelder B, Thomas Toth A, Venkataraman G, et al. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia. Clin Cancer Res. 2023;29:3151-3161 pubmed publisher
Colon Moran W, Baer A, Lamture G, Stapleton J, Fischer J, Bhattarai N. A short hepatitis C virus NS5A peptide expression by AAV vector modulates human T cell activation and reduces vector immunogenicity. Gene Ther. 2021;: pubmed publisher
Crean Tate K, Braley C, Dey G, Esakov E, Saygin C, Trestan A, et al. Pretreatment with LCK inhibitors chemosensitizes cisplatin-resistant endometrioid ovarian tumors. J Ovarian Res. 2021;14:55 pubmed publisher
Ormonde J, Li Z, Stegen C, Madrenas J. TAOK3 Regulates Canonical TCR Signaling by Preventing Early SHP-1-Mediated Inactivation of LCK. J Immunol. 2018;201:3431-3442 pubmed publisher
Baer A, Colon Moran W, Bhattarai N. Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways. Sci Rep. 2018;8:10910 pubmed publisher
Borlido J, Sakuma S, Raices M, Carrette F, Tinoco R, Bradley L, et al. Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. Nat Immunol. 2018;19:594-605 pubmed publisher
Bhattarai N, McLinden J, Xiang J, Mathahs M, Schmidt W, Kaufman T, et al. Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo. PLoS Pathog. 2017;13:e1006232 pubmed publisher
Clayton K, Haaland M, Douglas Vail M, Mujib S, Chew G, Ndhlovu L, et al. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014;192:782-91 pubmed publisher
product information
master code :
MAB7500
SKU :
MAB7500
product name :
Human Phospho-Lck (Y394) Antibody
unit size :
100 ug (also 25 ug)
description :
The Human Phospho-Lck (Y394) Antibody from R&D Systems is a mouse monoclonal antibody to Lck. This antibody reacts with human,mouse. The Human Phospho-Lck (Y394) Antibody has been validated for the following applications: Western Blot,Immunocytochemistry.
target :
Lck
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
755103
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
Phosphopeptide containing the human Lck Y394 site, Accession # P06239
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human Lck when phosphorylated at Y394. Due to high sequence homology, this antibody may cross-react with phosphorylated members of the Src family.
gene symbol :
LCK
top caption :
Detection of Human Phospho-Lck (Y394) antibody by Western Blot.
accessionNumbers :
P06239
applications :
Western Blot,Immunocytochemistry
USD :
469 USD
alt names :
EC 2.7.10, EC 2.7.10.2, Hck-3, Lcktkr, Leukocyte C-terminal Src kinase, LSK, LSTRA, Lymphocyte cell-specific protein-tyrosine kinase, lymphocyte-specific protein tyrosine kinase, p56(LSTRA) protein-tyrosine kinase, p56lck, p56-LCK, pp58lck, Protein YT16, Proto-oncogene Lck, proto-oncogene tyrosine-protein kinase LCK, T cell-specific protein-tyrosine kinase, T-lymphocyte specific protein tyrosine kinase p56lck, tyrosine-protein kinase Lck, YT16
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.