product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Glucosylceramidase/GBA Antibody
catalog :
MAB7410
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
812201
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
R&D Systems product webpage
citations: 7
Reference
Jong T, Gehrlein A, Sidransky E, Jagasia R, Chen Y. Characterization of Novel Human β-glucocerebrosidase Antibodies for Parkinson Disease Research. bioRxiv. 2023;: pubmed publisher
Davis S, Cook A, Hall J, Voskobiynyk Y, Carullo N, Boyle N, et al. Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations. Acta Neuropathol Commun. 2023;11:70 pubmed publisher
Davis O, Shin H, Lim C, Wu E, Kukurugya M, Maher C, et al. NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C. Dev Cell. 2021;56:260-276.e7 pubmed publisher
Arrant A, Roth J, Boyle N, Kashyap S, Hoffmann M, Murchison C, et al. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. Acta Neuropathol Commun. 2019;7:218 pubmed publisher
Kim Y, Yum M, Heo S, Kim T, Jin H, Bae J, et al. Pharmacologic properties of high-dose ambroxol in four patients with Gaucher disease and myoclonic epilepsy. J Med Genet. 2020;57:124-131 pubmed publisher
Adams J, Feuerborn M, Molina J, Wilden A, Adhikari B, Budden T, et al. Autophagy-lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease. Sci Rep. 2019;9:151 pubmed publisher
Atashrazm F, Hammond D, Perera G, Dobson Stone C, Mueller N, Pickford R, et al. Reduced glucocerebrosidase activity in monocytes from patients with Parkinson's disease. Sci Rep. 2018;8:15446 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB7410
SKU :
MAB7410
product name :
Human Glucosylceramidase/GBA Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Glucosylceramidase/GBA Antibody from R&D Systems is a mouse monoclonal antibody to Glucosylceramidase/GBA. This antibody reacts with human. The Human Glucosylceramidase/GBA Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Simple Western,Immunocytochemistry,Knockout Validated.
target :
Glucosylceramidase/GBA
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
812201
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 10 ug/mL, Immunocytochemistry 8-25 ug/mL, Knockout Validated 1 ug/mL
host :
Mouse
immunogen :
Chinese hamster ovary cell line CHO-derived recombinant human Glucosylceramidase/GBA, Met1-Gln536, Accession # P04062
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human Glucosylceramidase/GBA in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Cytosolic beta-Glucosidase/GBA3 is observed.
gene symbol :
GBA
top caption :
Detection of Human Glucosylceramidase/GBA antibody by Western Blot.
accessionNumbers :
P04062
applications :
Simple Western,Immunocytochemistry,Knockout Validated,Immunohistochemistry,Western Blot
USD :
499 USD
alt names :
Acid beta-glucosidase, alglucerase, Beta-glucocerebrosidase, D-glucosyl-N-acylsphingosine glucohydrolase, EC 3.2.1.45, GBA, GBA1, GC, GCB, GLUC, glucosidase, beta, acid, glucosidase, beta; acid (includes glucosylceramidase), glucosylceramidase, imiglucerase, lysosomal glucocerebrosidase
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.