Human TNF RII/TNFRSF1B Antibody | R&D Systems MAB726-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TNF RII/TNFRSF1B Antibody

catalog :

MAB726-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

22210

reactivity :

human, mouse

application :

western blot, ELISA, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 20

Reference
Ben Khemis M, Liu D, Pintard C, Song Z, Hurtado Nedelec M, Marie J, et al. TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes. Redox Biol. 2023;67:102898 pubmed publisher
Menevse A, Ammer L, Vollmann Zwerenz A, Kupczyk M, Lorenz J, Weidner L, et al. TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma. Acta Neuropathol Commun. 2023;11:75 pubmed publisher
Pesce B, Ribeiro C, Larrondo M, Ramos V, Soto L, Catal xe1 n D, et al. TNF-α Affects Signature Cytokines of Th1 and Th17 T Cell Subsets through Differential Actions on TNFR1 and TNFR2. Int J Mol Sci. 2022;23: pubmed publisher
Baram T, Oren N, Erlichman N, Meshel T, Ben Baruch A. Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Qu Y, Wang X, Bai S, Niu L, Zhao G, Yao Y, et al. The effects of TNF-α/TNFR2 in regulatory T cells on the microenvironment and progression of gastric cancer. Int J Cancer. 2022;150:1373-1391 pubmed publisher
Kobelt D, Zhang C, Clayton Lucey I, Glauben R, Voss C, Siegmund B, et al. Pro-inflammatory TNF-α and IFN-γ Promote Tumor Growth and Metastasis via Induction of MACC1. Front Immunol. 2020;11:980 pubmed publisher
Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, et al. Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1. Nat Commun. 2020;11:3459 pubmed publisher
Zhu W, Qiu Q, Luo H, Zhang F, Wu J, Zhu X, et al. High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1. Stem Cells Int. 2020;2020:4910767 pubmed publisher
Zhou Q, Wu X, Wang X, Yu Z, Pan T, Li Z, et al. The reciprocal interaction between tumor cells and activated fibroblasts mediated by TNF-α/IL-33/ST2L signaling promotes gastric cancer metastasis. Oncogene. 2019;: pubmed publisher
Ahmad R, Kochumon S, Chandy B, Shenouda S, Koshy M, Hasan A, et al. TNF-α Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-κB Signaling Pathways. Cell Physiol Biochem. 2019;52:908-921 pubmed publisher
Torrey H, Khodadoust M, Tran L, Baum D, DeFusco A, Kim Y, et al. Targeted killing of TNFR2-expressing tumor cells and Tregs by TNFR2 antagonistic antibodies in advanced Sézary syndrome. Leukemia. 2019;33:1206-1218 pubmed publisher
Wang L, Yang D, Tian J, Gao A, Shen Y, Ren X, et al. Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer. Oncotarget. 2017;8:26323-26333 pubmed publisher
Katanov C, Lerrer S, Liubomirski Y, Leider Trejo L, Meshel T, Bar J, et al. Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-? and the NF-?B pathway. Stem Cell Res Ther. 2015;6:87 pubmed publisher
Loosbroock C, Hunter K. Inhibiting TNF-Î± signaling does not attenuate induction of endotoxin tolerance. J Inflamm Res. 2014;7:159-67 pubmed publisher
Bastarache J, Sebag S, Grove B, Ware L. Interferon-? and tumor necrosis factor-? act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp Lung Res. 2011;37:509-17 pubmed publisher
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Rossol M, Meusch U, Pierer M, Kaltenhäuser S, Hantzschel H, Hauschildt S, et al. Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. J Immunol. 2007;179:4239-48 pubmed
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product information

master code :

MAB726

SKU :

MAB726-100

product name :

Human TNF RII/TNFRSF1B Antibody

unit size :

100 ug (also 500 ug, 25 ug)

description :

The Human TNF RII/TNFRSF1B Antibody from R&D Systems is a mouse monoclonal antibody to TNF RII/TNFRSF1B. This antibody reacts with human,mouse. The Human TNF RII/TNFRSF1B Antibody has been validated for the following applications: Neutralization,Array Development,ELISA Development,Flow Cytometry,Cell Culture,ELISA Capture,Western Blot,ELISA Capture (Matched Antibody Pair).

target :

TNF RII/TNFRSF1B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

22210

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human TNF RII/TNFRSF1B, Leu23-Asp257, Accession # P20333

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human TNF RII in ELISAs and Western blots. In ELISAs, no cross-reactivity or interference was observed with recombinant human (rh) TNF RI, recombinant mouse (rm) TNF RI, rmTNF RII, rmTNF-alpha , rhTNF-alpha , or rhTNF┐▀. In Western blots, this antibody does not cross-react with rhTNF RI, rmTNF RI, or rmTNF RII.

gene symbol :

TNFRSF1B

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

accessionNumbers :

P20333

applications :

Neutralization,Array Development,ELISA Development,Flow Cytometry,Cell Culture,ELISA Capture,Western Blot,ELISA Capture (Matched Antibody Pair)

USD :

469 USD

alt names :

CD120b, CD120b antigen, Etanercept, p75 TNF receptor, p75TBPII, p75TNFR, soluble TNFR1B variant 1, TNFBRp80 TNF-alpha receptor, TNF-R2, TNFR2TNFR1B, TNF-R75, TNFR80, TNFRII, TNF-RII, TNF-R-II, TNFR-II, TNFRSF1B, tumor necrosis factor beta receptor, tumor necrosis factor binding protein 2, Tumor necrosis factor receptor 2, tumor necrosis factor receptor superfamily member 1B, tumor necrosis factor receptor superfamily, member 1B, Tumor necrosis factor receptor type II

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage