Mouse IL-17/IL-17A Antibody | R&D Systems MAB721-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse IL-17/IL-17A Antibody

catalog :

MAB721-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

50101

reactivity :

human, mouse, rat

application :

western blot, ELISA

more info or order :

R&D Systems product webpage

citations: 25

Reference
Kasahara K, Sasaki N, Amin H, Tanaka T, Horibe S, Yamashita T, et al. Depletion of Foxp3+ regulatory T cells augments CD4+ T cell immune responses in atherosclerosis-prone hypercholesterolemic mice. Heliyon. 2022;8:e09981 pubmed publisher
Di Filippo M, Mancini A, Bellingacci L, Gaetani L, Mazzocchetti P, Zelante T, et al. Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis. Cell Rep. 2021;37:110094 pubmed publisher
Lee C, Moon S, Jeong J, Lee S, Lee M, Yoo S, et al. Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis. Cell Death Dis. 2018;9:401 pubmed publisher
Lee S, Kwon J, Kim S, Jung K, Cho M. Interferon-gamma regulates inflammatory cell death by targeting necroptosis in experimental autoimmune arthritis. Sci Rep. 2017;7:10133 pubmed publisher
Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3. Cell Physiol Biochem. 2017;42:1961-1972 pubmed publisher
Yau A, Tuncel J, Holmdahl R. The Major Histocompatibility Complex Class III Haplotype Ltab-Ncr3 Regulates Adjuvant-Induced but Not Antigen-Induced Autoimmunity. Am J Pathol. 2017;187:987-998 pubmed publisher
Tuncel J, Haag S, Holmdahl R. MHC class II alleles associated with Th1 rather than Th17 type immunity drive the onset of early arthritis in a rat model of rheumatoid arthritis. Eur J Immunol. 2017;47:563-574 pubmed publisher
Griffiths K, Ahmed M, Das S, Gopal R, Horne W, Connell T, et al. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016;7:13894 pubmed publisher
Lim J, Im K, Lee E, Kim N, Nam Y, Jeon Y, et al. Enhanced immunoregulation of mesenchymal stem cells by IL-10-producing type 1 regulatory T cells in collagen-induced arthritis. Sci Rep. 2016;6:26851 pubmed publisher
Haag S, Tuncel J, Thordardottir S, Mason D, Yau A, Dobritzsch D, et al. Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis. J Immunol. 2015;194:2539-50 pubmed publisher
Monin L, Griffiths K, Slight S, Lin Y, Rangel Moreno J, Khader S. Immune requirements for protective Th17 recall responses to Mycobacterium tuberculosis challenge. Mucosal Immunol. 2015;8:1099-109 pubmed publisher
Zhang X, Schaumburg C, Coursey T, Siemasko K, Volpe E, Gandhi N, et al. CD8? cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome. Mucosal Immunol. 2014;7:417-27 pubmed publisher
Hang L, Blum A, Setiawan T, Urban J, Stoyanoff K, Weinstock J. Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitis. J Immunol. 2013;191:1927-34 pubmed publisher
Lee J, Lee J, Park M, Lim M, Park E, Kim E, et al. Interferon gamma suppresses collagen-induced arthritis by regulation of Th17 through the induction of indoleamine-2,3-deoxygenase. PLoS ONE. 2013;8:e60900 pubmed publisher
Costa M, Bornstein V, Candéa A, Henriques Pons A, Henriques M, Penido C. CCL25 induces ???? integrin-dependent migration of IL-17? ?? T lymphocytes during an allergic reaction. Eur J Immunol. 2012;42:1250-60 pubmed publisher
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58:169-77 pubmed publisher
Leung J, Hang L, Blum A, Setiawan T, Stoyanoff K, Weinstock J. Heligmosomoides polygyrus abrogates antigen-specific gut injury in a murine model of inflammatory bowel disease. Inflamm Bowel Dis. 2012;18:1447-55 pubmed publisher
Beinborn M, Blum A, Hang L, Setiawan T, Schroeder J, Stoyanoff K, et al. TGF-beta regulates T-cell neurokinin-1 receptor internalization and function. Proc Natl Acad Sci U S A. 2010;107:4293-8 pubmed publisher
Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
Muranski P, Boni A, Antony P, Cassard L, Irvine K, Kaiser A, et al. Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood. 2008;112:362-73 pubmed publisher
Sheibanie A, Yen J, Khayrullina T, Emig F, Zhang M, Tuma R, et al. The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis. J Immunol. 2007;178:8138-47 pubmed
Lockhart E, Green A, Flynn J. IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 2006;177:4662-9 pubmed
Liang S, Tan X, Luxenberg D, Karim R, Dunussi Joannopoulos K, Collins M, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203:2271-9 pubmed
Khader S, Pearl J, Sakamoto K, Gilmartin L, Bell G, Jelley Gibbs D, et al. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol. 2005;175:788-95 pubmed
Lubberts E, Joosten L, Oppers B, van den Bersselaar L, Coenen de Roo C, Kolls J, et al. IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J Immunol. 2001;167:1004-13 pubmed

product information

brand :

R&D Systems

master code :

MAB721

SKU :

MAB721-100

product name :

Mouse IL-17/IL-17A Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Mouse IL-17/IL-17A Antibody from R&D Systems is a rat monoclonal antibody to IL-17/IL-17A. This antibody reacts with mouse,rat. The Mouse IL-17/IL-17A Antibody has been validated for the following applications: Western Blot,Electrophysiology,ELISA Development,ELISA Development (Capture),ELISpot Development,Luminex Development,ELISA Capture,ELISA Capture (Matched Antibody Pair).

target :

IL-17/IL-17A

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

50101

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Rat

immunogen :

E. coli -derived recombinant mouse IL-17, Thr22-Ala158, Accession # Q62386

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse,Rat

specificity :

Detects mouse IL-17 in ELISAs and Western blots. In direct ELISAs, 100% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer, 50% cross-reactivity with recombinant human IL-17, and 25% cross-reactivity with recombinant canine IL-17 is observed. No cross-reactivity with rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed. In Western blots, cross-reactivity with recombinant rat IL-17A is observed.

gene symbol :

IL17A

top caption :

Detection of Recombinant Mouse and Rat IL-17/IL-17A antibody by Western Blot.

accessionNumbers :

Q62386

applications :

ELISA Capture (Matched Antibody Pair),Electrophysiology,ELISA Development,ELISA Development (Capture),ELISpot Development,Luminex Development,Western Blot,ELISA Capture

USD :

489 USD

alt names :

CTLA8, CTLA-8, CTLA8cytotoxic T-lymphocyte-associated serine esterase 8, Cytotoxic T-lymphocyte-associated antigen 8, IL17, IL17A, IL-17A, IL-17Acytotoxic T-lymphocyte-associated protein 8, IL-17CTLA-8, IL17interleukin-17A, interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8), interleukin 17A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage