Human STING/TMEM173 Antibody | R&D Systems MAB7169 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human STING/TMEM173 Antibody

catalog :

MAB7169

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

723505

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 28

Reference
Jia M, Chai L, Wang J, Wang M, Qin D, Song H, et al. S-nitrosothiol homeostasis maintained by ADH5 facilitates STING-dependent host defense against pathogens. Nat Commun. 2024;15:1750 pubmed publisher
Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, et al. ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling. Nat Commun. 2023;14:6770 pubmed publisher
Zhang H, Li J, Yu Y, Ren J, Liu Q, Bao Z, et al. Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging. Cell Rep. 2023;42:112593 pubmed publisher
Ferecsk xf3 A, Smallwood M, Moore A, Liddle C, Newcombe J, Holley J, et al. STING-Triggered CNS Inflammation in Human Neurodegenerative Diseases. Biomedicines. 2023;11: pubmed publisher
Chappell D, Sandhu P, Wong J, Bhatt A, Liu X, Buhrlage S, et al. KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle. J Virol. 2023;97:e0176322 pubmed publisher
Lee J, Kwon M, Lim W, Yoo C, Yoon Y, Han D, et al. YAP inhibits HCMV replication by impairing STING-mediated nuclear transport of the viral genome. PLoS Pathog. 2022;18:e1011007 pubmed publisher
Pan M, Yin Y, Hu T, Wang X, Jia T, Sun J, et al. UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation. Autophagy. 2022;:1-17 pubmed publisher
Deater M, Tamhankar M, Lloyd R. TDRD3 is an antiviral restriction factor that promotes IFN signaling with G3BP1. PLoS Pathog. 2022;18:e1010249 pubmed publisher
Lepelley A, Della Mina E, van Nieuwenhove E, Waumans L, Fraitag S, Rice G, et al. Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A. J Exp Med. 2021;218: pubmed publisher
Lin B, Torreggiani S, Kahle D, Rumsey D, Wright B, Montes Cano M, et al. Case Report: Novel SAVI-Causing Variants in STING1 Expand the Clinical Disease Spectrum and Suggest a Refined Model of STING Activation. Front Immunol. 2021;12:636225 pubmed publisher
Segura Bayona S, Villamor Payà M, Attolini C, Koenig L, Sanchiz Calvo M, Boulton S, et al. Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres. Cell Rep. 2020;32:107983 pubmed publisher
Lepelley A, Martin Nicl xf3 s M, Le Bihan M, Marsh J, Uggenti C, Rice G, et al. Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling. J Exp Med. 2020;217: pubmed publisher
Lo Cigno I, Calati F, Borgogna C, Zevini A, Albertini S, Martuscelli L, et al. Human Papillomavirus E7 Oncoprotein Subverts Host Innate Immunity via SUV39H1-Mediated Epigenetic Silencing of Immune Sensor Genes. J Virol. 2020;94: pubmed publisher
RIEDL W, Acharya D, Lee J, Liu G, Serman T, Chiang C, et al. Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity. Cell Host Microbe. 2019;26:493-503.e6 pubmed publisher
Gentili M, Lahaye X, Nadalin F, Nader G, Puig Lombardi E, Hervé S, et al. The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus. Cell Rep. 2019;26:2377-2393.e13 pubmed publisher
Zhang L, Wei N, Cui Y, Hong Z, Liu X, Wang Q, et al. The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway. PLoS Pathog. 2018;14:e1007435 pubmed publisher
Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, et al. UBXN3B positively regulates STING-mediated antiviral immune responses. Nat Commun. 2018;9:2329 pubmed publisher
Ghosh R, Roy S, Franco S. PARP1 depletion induces RIG-I-dependent signaling in human cancer cells. PLoS ONE. 2018;13:e0194611 pubmed publisher
Albertini S, Lo Cigno I, Calati F, de Andrea M, Borgogna C, Dell Oste V, et al. HPV18 Persistence Impairs Basal and DNA Ligand-Mediated IFN-β and IFN-λ1 Production through Transcriptional Repression of Multiple Downstream Effectors of Pattern Recognition Receptor Signaling. J Immunol. 2018;200:2076-2089 pubmed publisher
Choi H, Park A, Kang S, Lee E, Lee T, Ra E, et al. Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses. Nat Commun. 2018;9:125 pubmed publisher
Chen Y, Shen Y, Hsia H, Tiang Y, Sung T, Chen L. Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway. Nat Struct Mol Biol. 2017;24:1124-1131 pubmed publisher
Deschamps T, Kalamvoki M. Evasion of the STING DNA-Sensing Pathway by VP11/12 of Herpes Simplex Virus 1. J Virol. 2017;91: pubmed publisher
Gaston J, Cheradame L, Yvonnet V, Déas O, Poupon M, Judde J, et al. Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents. Oncotarget. 2016;7:77205-77224 pubmed publisher
Dib B, Lin H, Maidana D, Tian B, Miller J, Bouzika P, et al. Mitochondrial DNA has a pro-inflammatory role in AMD. Biochim Biophys Acta. 2015;1853:2897-906 pubmed publisher
Hansen K, Prabakaran T, Laustsen A, Jørgensen S, Rahbæk S, Jensen S, et al. Listeria monocytogenes induces IFN? expression through an IFI16-, cGAS- and STING-dependent pathway. EMBO J. 2014;33:1654-66 pubmed publisher
Kalamvoki M, Roizman B. HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation. Proc Natl Acad Sci U S A. 2014;111:E611-7 pubmed publisher
Berg R, Rahbek S, Kofod Olsen E, Holm C, Melchjorsen J, Jensen D, et al. T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication. PLoS ONE. 2014;9:e84513 pubmed publisher
Schoggins J, MacDuff D, Imanaka N, Gainey M, Shrestha B, Eitson J, et al. Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature. 2014;505:691-5 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB7169

SKU :

MAB7169

product name :

Human STING/TMEM173 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human STING/TMEM173 Antibody from R&D Systems is a mouse monoclonal antibody to STING/TMEM173. This antibody reacts with human,mouse. The Human STING/TMEM173 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Immunoprecipitation,Intracellular Staining by Flow Cytometry,CyTOF-ready.

target :

STING/TMEM173

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

723505

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.2 ug/mL, Immunoprecipitation 2 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Immunocytochemistry 8-25 ug/mL, CyTOF-ready

host :

Mouse

immunogen :

E. coli -derived recombinant human STING/TMEM173, Ala215-Ser379, Accession # Q86WV6

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human STING/TMEM173 in direct ELISAs and Western blots.

gene symbol :

TMEM173

top caption :

Detection of Human STING/TMEM173 antibody by Western Blot.

accessionNumbers :

Q86WV6

applications :

Immunoprecipitation,Intracellular Staining by Flow Cytometry,CyTOF-ready,Immunohistochemistry,Western Blot,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry

USD :

469 USD

alt names :

endoplasmic reticulum IFN stimulator, Endoplasmic reticulum interferon stimulator, ERIS, FLJ38577, hMITA, hSTING, Mediator of IRF3 activation, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, SAVI, Stimulator of interferon genes protein, stimulator of interferon protein, sting, STING-beta, TMEM173, transmembrane protein 173

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage