Human SREBP2 Antibody | R&D Systems MAB7119 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human SREBP2 Antibody

catalog :

MAB7119

quantity :

100 ug (also 25 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

751512

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

R&D Systems product webpage

citations: 6

Reference
Ma Y, Wang Z, Sun J, Tang J, Zhou J, Dong M. Investigating the Diagnostic and Therapeutic Potential of SREBF2-Related Lipid Metabolism Genes in Colon Cancer. Onco Targets Ther. 2023;16:1027-1042 pubmed publisher
Okuno Y, Fukuhara A, Otsuki M, Shimomura I. ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors. JCI Insight. 2022;7: pubmed publisher
Han B, Alonso Valenteen F, Wang Z, Deng N, Lee T, Gao B, et al. A Chemokine Regulatory Loop Induces Cholesterol Synthesis in Lung-Colonizing Triple-Negative Breast Cancer Cells to Fuel Metastatic Growth. Mol Ther. 2021;: pubmed publisher
Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong Z, et al. Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export. Nat Commun. 2019;10:3521 pubmed publisher
Marwarha G, Claycombe Larson K, Lund J, Ghribi O. Palmitate-Induced SREBP1 Expression and Activation Underlies the Increased BACE 1 Activity and Amyloid Beta Genesis. Mol Neurobiol. 2018;: pubmed publisher
Torres Adorno A, Vitrac H, Qi Y, Tan L, Levental K, Fan Y, et al. Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2019;38:2135-2150 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB7119

SKU :

MAB7119

product name :

Human SREBP2 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human SREBP2 Antibody from R&D Systems is a mouse monoclonal antibody to SREBP2. This antibody reacts with human,mouse. The Human SREBP2 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry.

target :

SREBP2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

751512

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Immunohistochemistry 8-25 ug/mL, Immunocytochemistry 8-25 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human SREBP2, Leu242-Asp450, Accession # Q12772

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human SREBP2 in ELISA.

gene symbol :

SREBF2

top caption :

SREBP2 antibody in HepG2 Human Cell Line by Immunocytochemistry (ICC).

accessionNumbers :

Q12772

applications :

Immunocytochemistry,Immunohistochemistry,Western Blot

USD :

459 USD

alt names :

BHLHD2, bHLHd2sterol regulatory element-binding protein 2, Class D basic helix-loop-helix protein 2, SREBF2, SREBP2, SREBP2SREBP-2, sterol regulatory element binding transcription factor 2, Sterol regulatory element-binding transcription factor 2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage