product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse S1P1/EDG-1 Antibody
catalog :
MAB7089
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
713412
reactivity :
human, mouse
application :
immunohistochemistry, flow cytometry
more info or order :
R&D Systems product webpage
citations: 29
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 5c, s13b
Lee A, Pingali S, Pinilla Ibarz J, Atchison M, Koumenis C, Argon Y, et al. Loss of AID exacerbates the malignant progression of CLL. Leukemia. 2022;36:2430-2442 pubmed publisher
Ito T, Ishida Y, Zhang Y, Guichard V, Zhang W, Han R, et al. ILC2s navigate tissue redistribution during infection using stage-specific S1P receptors. bioRxiv. 2024;: pubmed publisher
Blanco D, Chapman N, Raynor J, Xu C, Su W, Kc A, et al. PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis. Nat Cell Biol. 2022;24:1642-1654 pubmed publisher
Nie J, Carpenter A, Chopp L, Chen T, Balmaceno Criss M, Ciucci T, et al. The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors. Nat Immunol. 2022;23:594-604 pubmed publisher
Tsiomita S, Liveri E, Vardaka P, Vogiatzi A, Skiadaresis A, Saridis G, et al. ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment. J Leukoc Biol. 2022;: pubmed publisher
Liu C, Ma L, Wang Y, Zhao J, Chen P, Chen X, et al. Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt. Sci Adv. 2021;7:eabg6262 pubmed publisher
Okuniewska M, Fang V, Baeyens A, Raghavan V, Lee J, Littman D, et al. SPNS2 enables T cell egress from lymph nodes during an immune response. Cell Rep. 2021;36:109368 pubmed publisher
Baeyens A, Bracero S, Chaluvadi V, Khodadadi Jamayran A, Cammer M, Schwab S. Monocyte-derived S1P in the lymph node regulates immune responses. Nature. 2021;592:290-295 pubmed publisher
Vallion R, Divoux J, Glauzy S, Ronin E, Lombardi Y, Lubrano Di Ricco M, et al. Regulatory T Cell Stability and Migration Are Dependent on mTOR. J Immunol. 2020;205:1799-1809 pubmed publisher
Venturutti L, Teater M, Zhai A, Chadburn A, Babiker L, Kim D, et al. TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate. Cell. 2020;182:297-316.e27 pubmed publisher
Geng X, Yanagida K, Akwii R, Choi D, Chen L, Ho Y, et al. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020;5: pubmed publisher
McCarron M, Irla M, Serge A, Soudja S, Marie J. Transforming Growth Factor-beta signaling in αβ thymocytes promotes negative selection. Nat Commun. 2019;10:5690 pubmed publisher
Shimano K, Maeda Y, Kataoka H, Murase M, Mochizuki S, Utsumi H, et al. Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells. PLoS ONE. 2019;14:e0226154 pubmed publisher
Choi J, Rudak P, Lesage S, Haeryfar S. Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties. J Immunol. 2019;203:1808-1819 pubmed publisher
Moretto M, Hwang S, Chen K, Khan I. Complex and Multilayered Role of IL-21 Signaling during Thymic Development. J Immunol. 2019;203:1242-1251 pubmed publisher
James K, Cosway E, LUCAS B, White A, Parnell S, Carvalho Gaspar M, et al. Endothelial cells act as gatekeepers for LTβR-dependent thymocyte emigration. J Exp Med. 2018;215:2984-2993 pubmed publisher
Lang M, Mori M, Ruer Laventie J, Pieters J. A Coronin 1-Dependent Decision Switch in Juvenile Mice Determines the Population of the Peripheral Naive T Cell Compartment. J Immunol. 2017;199:2421-2431 pubmed publisher
Audemard Verger A, Rivière M, Durand A, Peranzoni E, Guichard V, Hamon P, et al. Macrophages Induce Long-Term Trapping of ?? T Cells with Innate-like Properties within Secondary Lymphoid Organs in the Steady State. J Immunol. 2017;199:1998-2007 pubmed publisher
Golec D, Hoeppli R, Henao Caviedes L, McCann J, Levings M, Baldwin T. Thymic progenitors of TCR??+ CD8?? intestinal intraepithelial lymphocytes require RasGRP1 for development. J Exp Med. 2017;214:2421-2435 pubmed publisher
Mendoza A, Fang V, Chen C, Serasinghe M, Verma A, Muller J, et al. Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. Nature. 2017;546:158-161 pubmed publisher
Ruscher R, Kummer R, Lee Y, Jameson S, Hogquist K. CD8αα intraepithelial lymphocytes arise from two main thymic precursors. Nat Immunol. 2017;18:771-779 pubmed publisher
Turner V, Mabbott N. Ageing adversely affects the migration and function of marginal zone B cells. Immunology. 2017;151:349-362 pubmed publisher
Manna S, Kim J, Baugé C, Cam M, Zhao Y, Shetty J, et al. Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation. Nat Commun. 2015;6:8152 pubmed publisher
Maeda Y, Seki N, Kataoka H, Takemoto K, Utsumi H, Fukunari A, et al. IL-17-Producing Vγ4+ γδ T Cells Require Sphingosine 1-Phosphate Receptor 1 for Their Egress from the Lymph Nodes under Homeostatic and Inflammatory Conditions. J Immunol. 2015;195:1408-16 pubmed publisher
Xu S, Ou X, Huo J, Lim K, Huang Y, Chee S, et al. Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c. Nat Commun. 2015;6:6764 pubmed publisher
Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K. Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors. J Exp Med. 2014;211:2583-98 pubmed publisher
Nomachi A, Yoshinaga M, Liu J, Kanchanawong P, Tohyama K, Thumkeo D, et al. Moesin controls clathrin-mediated S1PR1 internalization in T cells. PLoS ONE. 2013;8:e82590 pubmed publisher
Arnon T, Horton R, Grigorova I, Cyster J. Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature. 2013;493:684-8 pubmed publisher
Green J, Suzuki K, Cho B, Willison L, Palmer D, Allen C, et al. The sphingosine 1-phosphate receptor S1P? maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12:672-80 pubmed publisher
product information
master code :
MAB7089
SKU :
MAB7089
product name :
Mouse S1P1/EDG-1 Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse S1P1/EDG-1 Antibody from R&D Systems is a rat monoclonal antibody to S1P1/EDG-1. This antibody reacts with human,mouse,transgenic mouse. The Mouse S1P1/EDG-1 Antibody has been validated for the following applications: Flow Cytometry,Immunohistochemistry,CyTOF-ready.
target :
S1P1/EDG-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
713412
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse S1P1/EDG-1 synthetic peptide (T4-H28), Accession # O08530
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects mouse S1P1/EDG-1 peptide in direct ELISAs.
gene symbol :
S1PR1
top caption :
Detection of S1P1/EDG-1 antibody in HEK293 Human Cell Line Transfected With S1P1/EDG-1 antibody by Flow Cytometry.
accessionNumbers :
O08530
applications :
Flow Cytometry,Immunohistochemistry,CyTOF-ready
USD :
489 USD
alt names :
CD363, CD363 antigen, CHEDG1, D1S3362, EDG1, EDG-1, EDG1edg-1, Endothelial differentiation G-protein coupled receptor 1, endothelial differentiation, sphingolipid G-protein-coupled receptor, 1, FLJ58121, S1P receptor 1, S1P receptor Edg-1, s1p1, S1P1ECGF1, S1PR1, sphingosine 1-phosphate receptor 1, sphingosine 1-phosphate receptor EDG1, Sphingosine 1-phosphate receptor Edg-1, sphingosine-1-phosphate receptor 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.