Human Isocitrate Dehydrogenase 1/IDH1 Antibody | R&D Systems MAB7049 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Isocitrate Dehydrogenase 1/IDH1 Antibody

catalog :

MAB7049

quantity :

100 ug (also 25 ug)

price :

429 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

843219

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 6

Reference
Yang H, Zhao X, Liu J, Jin M, Liu X, Yan J, et al. TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity. Oncogene. 2023;42:35-48 pubmed publisher
Zhang R, Chen D, Fan H, Wu R, Tu J, Zhang F, et al. Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells. Cell Chem Biol. 2022;: pubmed publisher
Chen D, Xia S, Zhang R, Li Y, Famulare C, Fan H, et al. Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells. Mol Cell. 2021;: pubmed publisher
Yang H, Xie S, Liang B, Tang Q, Liu H, Wang D, et al. Exosomal IDH1 increases the resistance of colorectal cancer cells to 5-Fluorouracil. J Cancer. 2021;12:4862-4872 pubmed publisher
Chen P, Cai L, HUFFMAN K, Yang C, Kim J, Faubert B, et al. Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells. Mol Cell. 2019;76:838-851.e5 pubmed publisher
Chen D, Xia S, Wang M, Lin R, Li Y, Mao H, et al. Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer. Cancer Discov. 2019;9:756-777 pubmed publisher

product information

master code :

MAB7049

SKU :

MAB7049

product name :

Human Isocitrate Dehydrogenase 1/IDH1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Isocitrate Dehydrogenase 1/IDH1 Antibody from R&D Systems is a mouse monoclonal antibody to Isocitrate Dehydrogenase 1/IDH1. This antibody reacts with human. The Human Isocitrate Dehydrogenase 1/IDH1 Antibody has been validated for the following applications: Immunoprecipitation,Immunohistochemistry,Western Blot,Simple Western,Immunocytochemistry,Knockout Validated.

target :

Isocitrate Dehydrogenase 1/IDH1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

843219

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human Isocitrate Dehydrogenase 1/IDH1, Ser2-Leu414, Accession # O75874

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Isocitrate Dehydrogenase 1/IDH1 in ELISAs and Western blots.

gene symbol :

IDH1

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human, Mouse, and Rat Isocitrate Dehydrogenase 1/IDH1 antibody by Western Blot.

accessionNumbers :

O75874

applications :

Immunoprecipitation,Immunohistochemistry,Western Blot,Simple Western,Immunocytochemistry,Knockout Validated

USD :

429 USD

alt names :

Cytosolic NADP-isocitrate dehydrogenase, EC 1.1.1.42, IDCD, IDH, IDH1, IDP, IDPC, isocitrate dehydrogenase [NADP] cytoplasmic, isocitrate dehydrogenase 1 (NADP+), soluble, NADP(+)-specific ICDH, NADP-dependent isocitrate dehydrogenase, cytosolic, NADP-dependent isocitrate dehydrogenase, peroxisomal, Oxalosuccinate decarboxylase, PICD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage