Human CXCR6 Antibody | R&D Systems MAB699-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCR6 Antibody

catalog :

MAB699-100

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

56811

reactivity :

human, rhesus macaque

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 26

Reference
Wang J, Chai Q, Lei Z, Wang Y, He J, Ge P, et al. LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. EMBO Mol Med. 2024;16:1755-1790 pubmed publisher
Lionetti M, Cola F, Chepizhko O, Fumagalli M, Font Clos F, Ravasio R, et al. MicroRNA-222 Regulates Melanoma Plasticity. J Clin Med. 2020;9: pubmed publisher
Facciotti F, Larghi P, Bosotti R, Vasco C, Gagliani N, Cordiglieri C, et al. Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2020;117:7305-7316 pubmed publisher
Ikeda T, Nishita M, Hoshi K, Honda T, Kakeji Y, Minami Y. Mesenchymal stem cell-derived CXCL16 promotes progression of gastric cancer cells by STAT3-mediated expression of Ror1. Cancer Sci. 2020;111:1254-1265 pubmed publisher
Syu G, Wang S, Ma G, Liu S, Pearce D, Prakash A, et al. Development and application of a high-content virion display human GPCR array. Nat Commun. 2019;10:1997 pubmed publisher
Adamski V, Mentlein R, Lucius R, Synowitz M, Held Feindt J, Hattermann K. The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16. Int J Mol Sci. 2017;18: pubmed publisher
Pichyangkul S, Spring M, Yongvanitchit K, Kum Arb U, Limsalakpetch A, Im Erbsin R, et al. Chemoprophylaxis with sporozoite immunization in P. knowlesi rhesus monkeys confers protection and elicits sporozoite-specific memory T cells in the liver. PLoS ONE. 2017;12:e0171826 pubmed publisher
Maghazachi A, Sand K, Al Jaderi Z. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity. Front Immunol. 2016;7:437 pubmed
Takiguchi G, Nishita M, Kurita K, Kakeji Y, Minami Y. Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis. Cancer Sci. 2016;107:290-7 pubmed publisher
Mir H, Singh R, Kloecker G, Lillard J, Singh S. CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases. Oncotarget. 2015;6:9985-98 pubmed
Hu W, Liu Y, Zhou W, Si L, Ren L. CXCL16 and CXCR6 are coexpressed in human lung cancer in vivo and mediate the invasion of lung cancer cell lines in vitro. PLoS ONE. 2014;9:e99056 pubmed publisher
Baek S, Kang S, Ra J. In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors. Exp Mol Med. 2011;43:596-603 pubmed publisher
Ruth J, Arendt M, Amin M, Ahmed S, Marotte H, Rabquer B, et al. Expression and function of CXCL16 in a novel model of gout. Arthritis Rheum. 2010;62:2536-44 pubmed publisher
Pacheco Rodriguez G, Kumaki F, Steagall W, Zhang Y, Ikeda Y, Lin J, et al. Chemokine-enhanced chemotaxis of lymphangioleiomyomatosis cells with mutations in the tumor suppressor TSC2 gene. J Immunol. 2009;182:1270-7 pubmed
Gaida M, Gunther F, Wagner C, Friess H, Giese N, Schmidt J, et al. Expression of the CXCR6 on polymorphonuclear neutrophils in pancreatic carcinoma and in acute, localized bacterial infections. Clin Exp Immunol. 2008;154:216-23 pubmed publisher
Wente M, Gaida M, Mayer C, Michalski C, Haag N, Giese T, et al. Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma. Int J Oncol. 2008;33:297-308 pubmed
Held Feindt J, Rehmke B, Mentlein R, Hattermann K, Knerlich F, Hugo H, et al. Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas. Glia. 2008;56:764-74 pubmed publisher
Kang S, Lim H, Andrisani O, Broxmeyer H, Kim C. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007;179:3724-33 pubmed
Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, et al. Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis. J Leukoc Biol. 2007;82:946-55 pubmed
Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, et al. CD molecules 2006--human cell differentiation molecules. J Immunol Methods. 2007;319:1-5 pubmed
Hirahara K, Liu L, Clark R, Yamanaka K, Fuhlbrigge R, Kupper T. The majority of human peripheral blood CD4+CD25highFoxp3+ regulatory T cells bear functional skin-homing receptors. J Immunol. 2006;177:4488-94 pubmed
Patel D, Bailey S, Gresham J, Schuchman D, Shelhamer J, Goldstein B, et al. TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells. Biochem Biophys Res Commun. 2006;347:1113-20 pubmed
Ruth J, Haas C, Park C, Amin M, Martinez R, Haines G, et al. CXCL16-mediated cell recruitment to rheumatoid arthritis synovial tissue and murine lymph nodes is dependent upon the MAPK pathway. Arthritis Rheum. 2006;54:765-78 pubmed
Lim H, Hillsamer P, Kim C. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses. J Clin Invest. 2004;114:1640-9 pubmed
Annels N, Willemze A, van der Velden V, Faaij C, van Wering E, Sie Go D, et al. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Blood. 2004;103:2806-8 pubmed
Campbell J, Qin S, Unutmaz D, Soler D, Murphy K, Hodge M, et al. Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire. J Immunol. 2001;166:6477-82 pubmed

product information

master code :

MAB699

SKU :

MAB699-100

product name :

Human CXCR6 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human CXCR6 Antibody from R&D Systems is a mouse monoclonal antibody to CXCR6. This antibody reacts with human,primate - macaca mulatta (rhesus macaque). The Human CXCR6 Antibody has been validated for the following applications: Immunohistochemistry,CyTOF-reported,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

CXCR6

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

56811

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

NS0 mouse myeloma cell line transfected with human CXCR6, Met1-Leu342, Accession # O00574

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human,Primate - Macaca mulatta (Rhesus Macaque)

specificity :

Stains human CXCR6 transfectants but not irrelevant transfectants.

gene symbol :

CXCR6

top caption :

Detection of CXCR6 antibody in Human PBMCs antibody by Flow Cytometry.

accessionNumbers :

O00574

applications :

Immunohistochemistry,CyTOF-reported,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

extended description :

Clone 56811 was used by HLDA to establish CD designation

USD :

469 USD

product details :

Clone 56811 was used by HLDA to establish CD designation

alt names :

Bonzo, BONZOG-protein coupled receptor bonzo, CD186, CD186 antigen, CDw186, chemokine (C-X-C motif) receptor 6, C-X-C chemokine receptor type 6, CXCR6, CXC-R6, CXCR-6, G protein-coupled receptor, STRL33, STRL33G-protein coupled receptor STRL33, TYMSTRCD186

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage