Human GITR Ligand/TNFSF18 Antibody | R&D Systems MAB6941 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human GITR Ligand/TNFSF18 Antibody

catalog :

MAB6941

quantity :

500 ug (also 25 ug)

price :

569 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

109101

reactivity :

human

application :

immunocytochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 3a immunocytochemistry; human; fig 2c	Chan M, Wu L, Yun Z, McKee T, Cabanero M, Zhao Y, et al. Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma. Commun Biol. 2021;4:914 pubmed publisher
	Schmiedel B, Werner A, Steinbacher J, Nuebling T, Buechele C, Grosse Hovest L, et al. Generation and preclinical characterization of a Fc-optimized GITR-Ig fusion protein for induction of NK cell reactivity against leukemia. Mol Ther. 2013;21:877-86 pubmed publisher
	Baltz K, Krusch M, Baessler T, Schmiedel B, Bringmann A, Brossart P, et al. Neutralization of tumor-derived soluble glucocorticoid-induced TNFR-related protein ligand increases NK cell anti-tumor reactivity. Blood. 2008;112:3735-43 pubmed publisher
	Baltz K, Krusch M, Bringmann A, Brossart P, Mayer F, Kloss M, et al. Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 2007;21:2442-54 pubmed
	Cardona I, Goleva E, Ou L, Leung D. Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. J Allergy Clin Immunol. 2006;117:688-95 pubmed
	Hanabuchi S, Watanabe N, Wang Y, Wang Y, Ito T, Shaw J, et al. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood. 2006;107:3617-23 pubmed
	Godfrey W, Spoden D, Ge Y, Baker S, Liu B, Levine B, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-8 pubmed

product information

master code :

MAB6941

SKU :

MAB6941

product name :

Human GITR Ligand/TNFSF18 Antibody

unit size :

500 ug (also 25 ug)

description :

The Human GITR Ligand/TNFSF18 Antibody from R&D Systems is a mouse monoclonal antibody to GITR Ligand/TNFSF18. This antibody reacts with human. The Human GITR Ligand/TNFSF18 Antibody has been validated for the following applications: ELISA Development,Flow Cytometry,Neutralization,Blockade of Receptor-ligand Interaction,CyTOF-ready.

target :

GITR Ligand/TNFSF18

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

109101

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human GITR Ligand/TNFSF18, Glu52-Ser177, Accession # Q9UNG2

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human GITR Ligand/TNFSF18 in direct ELISAs.

gene symbol :

TNFSF18

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

accessionNumbers :

Q9UNG2

applications :

ELISA Development,Flow Cytometry,Neutralization,Blockade of Receptor-ligand Interaction,CyTOF-ready

USD :

569 USD

alt names :

Activation-inducible TNF-related ligand, AITRL, AITRLMGC138237, GITRL, GITRLglucocorticoid-induced TNFR-related protein ligand, Glucocorticoid-induced TNF-related ligand, hGITRLGITR ligand, TL6AITR ligand, TNFSF18, tumor necrosis factor (ligand) superfamily, member 18, tumor necrosis factor ligand superfamily member 18

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage