Human GITR/TNFRSF18 Antibody | R&D Systems MAB689 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human GITR/TNFRSF18 Antibody

catalog :

MAB689

quantity :

100 ug (also 25 ug, 500 ug)

price :

359 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

110416

reactivity :

human

application :

western blot, ELISA, flow cytometry

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 4d	Canete P, Sweet R, Gonzalez Figueroa P, Papa I, Ohkura N, Bolton H, et al. Regulatory roles of IL-10-producing human follicular T cells. J Exp Med. 2019;: pubmed publisher
	Heine A, Held S, Schulte Schrepping J, Wolff J, Klee K, Ulas T, et al. Generation and functional characterization of MDSC-like cells. Oncoimmunology. 2017;6:e1295203 pubmed publisher
	Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, et al. The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface. PLoS ONE. 2014;9:e103254 pubmed publisher
	Schmiedel B, Werner A, Steinbacher J, Nuebling T, Buechele C, Grosse Hovest L, et al. Generation and preclinical characterization of a Fc-optimized GITR-Ig fusion protein for induction of NK cell reactivity against leukemia. Mol Ther. 2013;21:877-86 pubmed publisher
	Mandapathil M, Szczepanski M, Harasymczuk M, Ren J, Cheng D, Jackson E, et al. CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma. Oncoimmunology. 2012;1:659-669 pubmed
	Savage N, De Boer T, Walburg K, Joosten S, van Meijgaarden K, Geluk A, et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J Immunol. 2008;181:2220-6 pubmed
	Baltz K, Krusch M, Bringmann A, Brossart P, Mayer F, Kloss M, et al. Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 2007;21:2442-54 pubmed
	Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, et al. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur J Immunol. 2004;34:3485-96 pubmed
	Godfrey W, Spoden D, Ge Y, Baker S, Liu B, Levine B, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-8 pubmed
	Zheng S, Wang J, Gray J, Soucier H, Horwitz D. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol. 2004;172:5213-21 pubmed

product information

brand :

R&D Systems

master code :

MAB689

SKU :

MAB689-100

product name :

Human GITR/TNFRSF18 Antibody

description :

The Human GITR/TNFRSF18 Antibody from R&D Systems is a mouse monoclonal antibody to GITR/TNFRSF18. This antibody reacts with human. The Human GITR/TNFRSF18 Antibody has been validated for the following applications: Western Blot, Flow Cytometry, Blockade of Receptor-ligand Interaction, CyTOF-ready, ELISA Capture (Matched Antibody Pair).

target :

GITR/TNFRSF18

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

110416

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18, Gln26-Glu161 (Thr43Ala), Accession # Q9Y5U5

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human GITR in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) 4-1BB, recombinant mouse (rm) 4-1BB, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFAS, rmGITR, rhHVEM, rhLymphotoxin R beta , rmLymphotoxin R beta , rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.

gene symbol :

TNFRSF18

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB689

accessionNumbers :

Q9Y5U5

applications :

Western Blot, Flow Cytometry, Blockade of Receptor-ligand Interaction, CyTOF-ready, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

359 USD

alt names :

Activation-inducible TNFR family receptor, AITR, AITRTNF receptor superfamily activation-inducible protein, CD357, CD357 antigen, GITR-D, GITRtumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, TNFRSF18, tumor necrosis factor receptor superfamily, member 18

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.