Human GITR/TNFRSF18 Antibody | R&D Systems MAB689-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human GITR/TNFRSF18 Antibody

catalog :

MAB689-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

110416

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, neutralization, flow cytometry, blocking or activating experiments, mass cytometry

more info or order :

R&D Systems product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
mass cytometry; human; loading ...; fig s4a	Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, et al. Human induced-T-to-natural killer cells have potent anti-tumour activities. Biomark Res. 2022;10:13 pubmed publisher
blocking or activating experiments; human; fig 4c	Chan M, Wu L, Yun Z, McKee T, Cabanero M, Zhao Y, et al. Blocking the GITR-GITRL pathway to overcome resistance to therapy in sarcomatoid malignant pleural mesothelioma. Commun Biol. 2021;4:914 pubmed publisher
	Hwang S, Lim J, Kang H, Jeong J, Joung J, Heo J, et al. Predictive biomarkers for the responsiveness of recurrent glioblastomas to activated killer cell immunotherapy. Cell Biosci. 2023;13:17 pubmed publisher
	Heine A, Held S, Schulte Schrepping J, Wolff J, Klee K, Ulas T, et al. Generation and functional characterization of MDSC-like cells. Oncoimmunology. 2017;6:e1295203 pubmed publisher
	Tigue N, Bamber L, Andrews J, Ireland S, Hair J, Carter E, et al. MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential. Oncoimmunology. 2017;6:e1280645 pubmed publisher
	Lee F, Luevano M, Veys P, Yong K, Madrigal A, Shaw B, et al. The effects of CAMPATH-1H on cell viability do not correlate to the CD52 density on the cell surface. PLoS ONE. 2014;9:e103254 pubmed publisher
	Schmiedel B, Werner A, Steinbacher J, Nuebling T, Buechele C, Grosse Hovest L, et al. Generation and preclinical characterization of a Fc-optimized GITR-Ig fusion protein for induction of NK cell reactivity against leukemia. Mol Ther. 2013;21:877-86 pubmed publisher
	Mandapathil M, Szczepanski M, Harasymczuk M, Ren J, Cheng D, Jackson E, et al. CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma. Oncoimmunology. 2012;1:659-669 pubmed
	Savage N, De Boer T, Walburg K, Joosten S, van Meijgaarden K, Geluk A, et al. Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1. J Immunol. 2008;181:2220-6 pubmed
	Baltz K, Krusch M, Bringmann A, Brossart P, Mayer F, Kloss M, et al. Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. FASEB J. 2007;21:2442-54 pubmed
	Birebent B, Lorho R, Lechartier H, de Guibert S, Alizadeh M, Vu N, et al. Suppressive properties of human CD4+CD25+ regulatory T cells are dependent on CTLA-4 expression. Eur J Immunol. 2004;34:3485-96 pubmed
	Godfrey W, Spoden D, Ge Y, Baker S, Liu B, Levine B, et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood. 2005;105:750-8 pubmed
	Zheng S, Wang J, Gray J, Soucier H, Horwitz D. Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J Immunol. 2004;172:5213-21 pubmed

product information

brand :

R&D Systems

master code :

MAB689

SKU :

MAB689-100

product name :

Human GITR/TNFRSF18 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human GITR/TNFRSF18 Antibody from R&D Systems is a mouse monoclonal antibody to GITR/TNFRSF18. This antibody reacts with human. The Human GITR/TNFRSF18 Antibody has been validated for the following applications: Flow Cytometry,Neutralization,Functional Assay,Immunocytochemistry,Western Blot,Blockade of Receptor-ligand Interaction,ELISA Capture (Matched Antibody Pair),CyTOF-ready.

target :

GITR/TNFRSF18

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

110416

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, Blockade of Receptor-ligand Interaction 1-2 ug/mL, CyTOF-ready, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human GITR/TNFRSF18, Gln26-Glu161 (Thr43Ala), Accession # Q9Y5U5

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human GITR in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) 4-1BB, recombinant mouse (rm) 4-1BB, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFAS, rmGITR, rhHVEM, rhLymphotoxin R▀, rmLymphotoxin R▀, rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.

gene symbol :

TNFRSF18

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

accessionNumbers :

Q9Y5U5

applications :

Western Blot,Blockade of Receptor-ligand Interaction,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Flow Cytometry,Neutralization,Immunocytochemistry,Functional Assay

USD :

459 USD

alt names :

Activation-inducible TNFR family receptor, AITR, AITRTNF receptor superfamily activation-inducible protein, CD357, CD357 antigen, GITR-D, GITRtumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, TNFRSF18, tumor necrosis factor receptor superfamily, member 18

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage