Human TRAIL/TNFSF10 Antibody | R&D Systems MAB687 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TRAIL/TNFSF10 Antibody

catalog :

MAB687

quantity :

500 ug (also 25 ug)

price :

569 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

75402

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human	Labovsky V, Martinez L, Davies K, Garcia Rivello H, Calcagno M, Matas A, et al. Association between ligands and receptors related to the progression of early breast cancer in tumor epithelial and stromal cells. Clin Breast Cancer. 2015;15:e13-21 pubmed publisher
flow cytometry; human	Stary G, Klein I, Kohlhofer S, Koszik F, Scherzer T, Müllauer L, et al. Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Blood. 2009;114:3854-63 pubmed publisher
flow cytometry; human	Secchiero P, Lamberti G, Corallini F, Melloni E, Guarnotta C, Sebastiani A, et al. Conjunctival sac fluid contains elevated levels of soluble TRAIL: implications for the anti-tumoral surveillance of the anterior surface of the eye. J Cell Physiol. 2009;218:199-204 pubmed publisher
flow cytometry; human	Secchiero P, Melloni E, Corallini F, Beltrami A, Alviano F, Milani D, et al. Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Stem Cells. 2008;26:2955-63 pubmed publisher
flow cytometry; human	Corallini F, Celeghini C, Rizzardi C, Pandolfi A, Di Silvestre S, Vaccarezza M, et al. Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro. J Cell Physiol. 2007;212:89-95 pubmed
flow cytometry; human	Morel J, Audo R, Hahne M, Combe B. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt. J Biol Chem. 2005;280:15709-18 pubmed
	Liu S, Polsdofer E, Zhou L, Ruan S, Lyu H, Hou D, et al. Upregulation of endogenous TRAIL-elicited apoptosis is essential for metformin-mediated antitumor activity against TNBC and NSCLC. Mol Ther Oncolytics. 2021;21:303-314 pubmed publisher
	Lima T, Iglesias Gato D, Souza L, Stenvang J, Lima D, Røder M, et al. Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
	Dufour F, Rattier T, Constantinescu A, Zischler L, MorlÃ© A, Ben Mabrouk H, et al. TRAIL receptor gene editing unveils TRAIL-R1 as a master player of apoptosis induced by TRAIL and ER stress. Oncotarget. 2017;8:9974-9985 pubmed publisher
	Siegemund M, Pollak N, Seifert O, Wahl K, Hanak K, Vogel A, et al. Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity. Cell Death Dis. 2012;3:e295 pubmed publisher
	Zahn S, Rehkämper C, Ferring Schmitt S, Bieber T, Tuting T, Wenzel J. Interferon-? stimulates TRAIL expression in human keratinocytes and peripheral blood mononuclear cells: implications for the pathogenesis of cutaneous lupus erythematosus. Br J Dermatol. 2011;165:1118-23 pubmed publisher
	Schneider B, Munkel S, Krippner Heidenreich A, Grunwald I, Wels W, Wajant H, et al. Potent antitumoral activity of TRAIL through generation of tumor-targeted single-chain fusion proteins. Cell Death Dis. 2010;1:e68 pubmed publisher
	Stary G, Bangert C, Tauber M, Strohal R, Kopp T, Stingl G. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J Exp Med. 2007;204:1441-51 pubmed
	Campioni D, Secchiero P, Corallini F, Melloni E, Capitani S, Lanza F, et al. Evidence for a role of TNF-related apoptosis-inducing ligand (TRAIL) in the anemia of myelodysplastic syndromes. Am J Pathol. 2005;166:557-63 pubmed

product information

master code :

MAB687

SKU :

MAB687

product name :

Human TRAIL/TNFSF10 Antibody

unit size :

500 ug (also 25 ug)

description :

The Human TRAIL/TNFSF10 Antibody from R&D Systems is a mouse monoclonal antibody to TRAIL/TNFSF10. This antibody reacts with human,rat. The Human TRAIL/TNFSF10 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry,Immunohistochemistry,CyTOF-ready.

target :

TRAIL/TNFSF10

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

75402

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TRAIL, Thr95-Gly281, Accession # P50591

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Rat

specificity :

Detects human TRAIL in direct ELISAs.

gene symbol :

TNFSF10

top caption :

Detection of TRAIL/TNFSF10 antibody in Human PBMCs antibody by Flow Cytometry.

accessionNumbers :

P50591

applications :

Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry,Immunohistochemistry,CyTOF-ready

USD :

569 USD

alt names :

Apo-2 ligand, APO2L, Apo-2Ltumor necrosis factor (ligand) family, member 10, APO2Ltumor necrosis factor apoptosis-inducing ligand splice variant delta, CD253, CD253 antigen, Protein TRAIL, TL2, TNF-related apoptosis-inducing ligand, TNFSF10, TRAILTNF-related apoptosis inducing ligand TRAIL, tumor necrosis factor (ligand) superfamily, member 10, tumor necrosis factor ligand superfamily member 10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage