Human CXCL11/I-TAC Antibody | R&D Systems MAB672-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CXCL11/I-TAC Antibody

catalog :

MAB672-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

87328

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 13

Reference
Zhang W, Lyu P, Andreev D, Jia Y, Zhang F, Bozec A. Hypoxia-immune-related microenvironment prognostic signature for osteosarcoma. Front Cell Dev Biol. 2022;10:974851 pubmed publisher
Lee K, Lin C, Servetto A, Bae J, Kandagatla V, Ye D, et al. Epigenetic Repression of STING by MYC Promotes Immune Evasion and Resistance to Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer. Cancer Immunol Res. 2022;10:829-843 pubmed publisher
Antonia A, Gibbs K, Trahair E, Pittman K, Martin A, Schott B, et al. Pathogen Evasion of Chemokine Response Through Suppression of CXCL10. Front Cell Infect Microbiol. 2019;9:280 pubmed publisher
Yuan X, Liu Y, Li G, Lan Z, Ma M, Li H, et al. Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection. Cancer Immunol Res. 2019;7:1440-1456 pubmed publisher
Zhang M, Deng X, Guan X, Geng L, Fu M, Zhang B, et al. Herpes Simplex Virus Type 2 Infection-Induced Expression of CXCR3 Ligands Promotes CD4+ T Cell Migration and Is Regulated by the Viral Immediate-Early Protein ICP4. Front Immunol. 2018;9:2932 pubmed publisher
Harris D, Chandrasekharan U, Bandyopadhyay S, Willard B, DiCorleto P. PRMT5-Mediated Methylation of NF-ÎºB p65 at Arg174 Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-Î± and IFN-Î³ Costimulation. PLoS ONE. 2016;11:e0148905 pubmed publisher
Pinto S, Martinez Romero A, O Connor J, Gil Benso R, San Miguel T, Terrádez L, et al. Intracellular coexpression of CXC- and CC- chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation. BMC Cancer. 2014;14:118 pubmed publisher
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
Yoon K, Park C, You I, Choi H, Lee K, Im S, et al. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2010;51:643-50 pubmed publisher
Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, et al. Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J Immunol. 2007;179:4272-82 pubmed
Curbishley S, Eksteen B, Gladue R, Lalor P, Adams D. CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow. Am J Pathol. 2005;167:887-99 pubmed
Kohrgruber N, Groger M, Meraner P, Kriehuber E, Petzelbauer P, Brandt S, et al. Plasmacytoid dendritic cell recruitment by immobilized CXCR3 ligands. J Immunol. 2004;173:6592-602 pubmed
Liu L, Jarjour N, Busse W, Kelly E. Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma. Am J Respir Crit Care Med. 2004;169:1118-24 pubmed

product information

master code :

MAB672

SKU :

MAB672-100

product name :

Human CXCL11/I-TAC Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human CXCL11/I-TAC Antibody from R&D Systems is a mouse monoclonal antibody to CXCL11/I-TAC. This antibody reacts with human. The Human CXCL11/I-TAC Antibody has been validated for the following applications: Western Blot,Bioassay,ELISA Development,Immunodepletion,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).

target :

CXCL11/I-TAC

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

87328

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human CXCL11/I-TAC, Phe22-Phe94, Accession # O14625

isotype :

IgG2a

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human CXCL11/I-TAC in ELISAs and Western blots. In ELISAs, this antibody does not cross-react with recombinant human (rh) CXCL5, 7, 8, 9, or 10. In Western blots, this antibody shows less than 1% cross-reactivity with rhCXCL1, 2, 3, 5, 6, 7, IL-8/CXCL8, 9, 10, 13, CXCL12/SDF-1 alpha , CXCL12/SDF-1▀, rmCXCL1, 2, 6, 9, 10, CXCL12/SDF-1 alpha , rmCXCL13, rrCXCL1, CXCL3/CINC-2 alpha , CXCL3/CINC-2▀, or rpIL-8/CXCL8.

gene symbol :

CXCL11

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Chemotaxis Induced by CXCL11/I-TAC and Neutralization by Human CXCL11/I-TAC Antibody.

accessionNumbers :

O14625

applications :

Western Blot,Bioassay,ELISA Development,Immunodepletion,Flow Cytometry,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair)

USD :

499 USD

alt names :

beta-R1, b-R1, chemokine (C-X-C motif) ligand 11, H174, H174IP9, Interferon gamma-inducible protein 9, Interferon-inducible T-cell alpha chemoattractant, IP-9member 11, ITAC, I-TAC, I-TACMGC102770, SCYB9B, small inducible cytokine subfamily B (Cys-X-Cys), member 9B, Small-inducible cytokine B11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage