product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human DNAM-1/CD226 Antibody
catalog :
MAB666-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
102511
reactivity :
human
application :
western blot, neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 10
Reference
Sen Santara S, Lee D, Crespo x, Hu J, Walker C, Ma X, et al. The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. Nature. 2023;616:348-356 pubmed publisher
Chashchina A, Märklin M, Hinterleitner C, Salih H, Heitmann J, Klimovich B. DNAM-1/CD226 is functionally expressed on acute myeloid leukemia (AML) cells and is associated with favorable prognosis. Sci Rep. 2021;11:18012 pubmed publisher
Leung E, Ennis D, Kennedy P, Hansell C, Dowson S, Farquharson M, et al. NK Cells Augment Oncolytic Adenovirus Cytotoxicity in Ovarian Cancer. Mol Ther Oncolytics. 2020;16:289-301 pubmed publisher
Muñoz D, Yannone S, Daemen A, Sun Y, Vakar Lopez F, Kawahara M, et al. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. JCI Insight. 2019;5: pubmed publisher
Najar M, Fayyad Kazan M, Meuleman N, Bron D, Fayyad Kazan H, Lagneaux L. Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation. J Cell Commun Signal. 2018;12:673-688 pubmed publisher
López Cobo S, Pieper N, Campos Silva C, García Cuesta E, Reyburn H, Paschen A, et al. Impaired NK cell recognition of vemurafenib-treated melanoma cells is overcome by simultaneous application of histone deacetylase inhibitors. Oncoimmunology. 2018;7:e1392426 pubmed publisher
Espinoza J, Trung L, Inaoka P, Yamada K, An D, Mizuno S, et al. The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxid Med Cell Longev. 2017;2017:6781872 pubmed publisher
Davis Z, Sowrirajan B, Cogswell A, Ward J, Planelles V, Barker E. CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells. AIDS Res Hum Retroviruses. 2017;33:93-100 pubmed publisher
Huijskens M, Walczak M, Sarkar S, Atrafi F, Senden Gijsbers B, Tilanus M, et al. Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy. Cytotherapy. 2015;17:613-20 pubmed publisher
Magnani C, Alberigo G, Bacchetta R, Serafini G, Andreani M, Roncarolo M, et al. Killing of myeloid APCs via HLA class I, CD2 and CD226 defines a novel mechanism of suppression by human Tr1 cells. Eur J Immunol. 2011;41:1652-62 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB666
SKU :
MAB666-100
product name :
Human DNAM-1/CD226 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human DNAM-1/CD226 Antibody from R&D Systems is a mouse monoclonal antibody to DNAM-1/CD226. This antibody reacts with human. The Human DNAM-1/CD226 Antibody has been validated for the following applications: Neutralization,Bioassay,Flow Cytometry,Western Blot,CyTOF-ready.
target :
DNAM-1/CD226
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
102511
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Neutralization, CyTOF-ready
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human DNAM-1/CD226, Glu19-Asn247 (predicted), Accession # Q15762
isotype :
IgG1
purity :
Protein A or G purified from ascites
species :
Human
specificity :
Detects human DNAM-1/CD226 in direct ELISAs and Western blots.
gene symbol :
CD226
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of DNAM-1/CD226 antibody in Human PBMCs antibody by Flow Cytometry.
accessionNumbers :
Q15762
applications :
Western Blot,CyTOF-ready,Bioassay,Flow Cytometry,Neutralization
USD :
469 USD
alt names :
CD226, CD226 antigenplatelet and T cell activation antigen 1, CD226 molecule, DNAM1, DNAM1adhesion glycoprotein, DNAM-1DNAX accessory molecule-1, DNAX accessory molecule 1, PTA1, T lineage-specific activation antigen 1 antigen, TLiSA1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.