Human Activin B MAb (Clone 146807) | R&D Systems MAB659-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Activin B MAb (Clone 146807)

catalog :

MAB659-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

146807

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 5

Reference
Reader K, John McHaffie S, Zellhuber McMillan S, Jowett T, Mottershead D, Cunliffe H, et al. Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth. Cancers (Basel). 2022;15: pubmed publisher
Morabito M, Larcher M, Cavalli F, Foray C, Forget A, Mirabal Ortega L, et al. An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma. EMBO Mol Med. 2019;11:e9830 pubmed publisher
Spottiswoode N, Armitage A, Williams A, Fyfe A, Biswas S, Hodgson S, et al. Role of Activins in Hepcidin Regulation during Malaria. Infect Immun. 2017;85: pubmed publisher
Dussiot M, Maciel T, Fricot A, Chartier C, Negre O, Veiga J, et al. An activin receptor IIA ligand trap corrects ineffective erythropoiesis in ?-thalassemia. Nat Med. 2014;20:398-407 pubmed publisher
Kupershmidt L, Amit T, Bar Am O, Youdim M, Blumenfeld Z. The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases. J Neurochem. 2007;103:962-71 pubmed

product information

brand :

R&D Systems

master code :

MAB659

SKU :

MAB659-100

product name :

Human Activin B MAb (Clone 146807)

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human Activin B MAb (Clone 146807) from R&D Systems is a mouse monoclonal antibody to Activin B/Inhibin beta B. This antibody reacts with human,mouse,rat. The Human Activin B MAb (Clone 146807) has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin.

target :

Activin B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

146807

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Neutralization 0.6-3.0 ug/mL

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human Activin B, Gly293-Ala407, Accession # Q53T31

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Rat

specificity :

Detects human Activin B ▀B subunit in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) Inhibin B or rhActivin A is observed. In Western blots, approximately 20% cross-reactivity with rhInhibin B is observed and no cross-reactivity with rhActivin A or recombinant mouse Activin A is observed.

gene symbol :

INHBB

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Hemoglobin Expression Induced by Activin B and Neutralization by Human Activin B Antibody.

accessionNumbers :

Q53T31

applications :

Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization

USD :

489 USD

alt names :

activin AB beta polypeptide, Activin beta-B chain, INHBB, inhibin beta B chain, inhibin, beta B, inhibin, beta B (activin AB beta polypeptide), Inhibin, beta-2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage