Human Activin RIA/ALK-2 Antibody | R&D Systems MAB637-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Activin RIA/ALK-2 Antibody

catalog :

MAB637-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

71412

reactivity :

human, mouse

application :

western blot, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 6

Reference
Aykul S, Huang L, Wang L, Das N, Reisman S, Ray Y, et al. Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1. J Clin Invest. 2022;132: pubmed publisher
Kimishima Y, Misaka T, Yokokawa T, Wada K, Ueda K, Sugimoto K, et al. Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils. Nat Commun. 2021;12:6177 pubmed publisher
Arai H, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, et al. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 2019;29:603-616.e5 pubmed publisher
Hatsell S, Idone V, Wolken D, Huang L, Kim H, Wang L, et al. ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A. Sci Transl Med. 2015;7:303ra137 pubmed publisher
Huse K, Bakkebø M, Oksvold M, Forfang L, Hilden V, Stokke T, et al. Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7. Eur J Immunol. 2011;41:3135-45 pubmed publisher
Zeisberg M, Yang C, Martino M, Duncan M, Rieder F, Tanjore H, et al. Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J Biol Chem. 2007;282:23337-47 pubmed

product information

master code :

MAB637

SKU :

MAB637-100

product name :

Human Activin RIA/ALK-2 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human Activin RIA/ALK-2 Antibody from R&D Systems is a mouse monoclonal antibody to Activin RIA/ALK-2/Activin Receptor Type 1. This antibody reacts with human,mouse. The Human Activin RIA/ALK-2 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Activin RIA/ALK-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

71412

conjugate :

Unconjugated

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Activin RIA/ALK-2, Asp23-Val124, Accession # Q04771

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human Activin RIA/ALK-2 in direct ELISAs and Western blots.

gene symbol :

ACVR1

top caption :

Activin RIA/ALK-2 antibody in HUVEC Human Cells by Immunocytochemistry (ICC).

accessionNumbers :

Q04771

applications :

Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

469 USD

alt names :

activin A receptor, type I, ActivinRIA, ACTRI, ACVR1, ACVR1A, ACVRLK2, ALK2, ALK-2, FOP, SKR1, TSRI

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage