Human CD40/TNFRSF5 Antibody | R&D Systems MAB6321-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CD40/TNFRSF5 Antibody

catalog :

MAB6321-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

82111

reactivity :

human, mouse

application :

immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 9

Reference
Harder I, M xfc nchhalfen M, Andrieux G, Boerries M, Grimbacher B, Eibel H, et al. Dysregulated PI3K Signaling in B Cells of CVID Patients. Cells. 2022;11: pubmed publisher
Lim C, Chang J, Lee W, Kim J, Park I. CD40 Agonists Alter the Pancreatic Cancer Microenvironment by Shifting the Macrophage Phenotype toward M1 and Suppress Human Pancreatic Cancer in Organotypic Slice Cultures. Gut Liver. 2022;16:645-659 pubmed publisher
Brummer G, Fang W, Smart C, Zinda B, Alissa N, Berkland C, et al. CCR2 signaling in breast carcinoma cells promotes tumor growth and invasion by promoting CCL2 and suppressing CD154 effects on the angiogenic and immune microenvironments. Oncogene. 2020;39:2275-2289 pubmed publisher
Schlievert P, Cahill M, Hostager B, Brosnahan A, Klingelhutz A, Gourronc F, et al. Staphylococcal Superantigens Stimulate Epithelial Cells through CD40 To Produce Chemokines. MBio. 2019;10: pubmed publisher
Hatterer E, Barba L, Noraz N, Daubeuf B, Aubry Lachainaye J, von der Weid B, et al. Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation. MAbs. 2019;11:322-334 pubmed publisher
Maddur M, Sharma M, Hegde P, Stephen Victor E, Pulendran B, Kaveri S, et al. Human B cells induce dendritic cell maturation and favour Th2 polarization by inducing OX-40 ligand. Nat Commun. 2014;5:4092 pubmed publisher
Heine G, Drozdenko G, Grün J, Chang H, Radbruch A, Worm M. Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts. Eur J Immunol. 2014;44:1615-21 pubmed publisher
Loebel M, Strohschein K, Giannini C, Koelsch U, Bauer S, Doebis C, et al. Deficient EBV-specific B- and T-cell response in patients with chronic fatigue syndrome. PLoS ONE. 2014;9:e85387 pubmed publisher
Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, Aissat A, et al. Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes. 2010;59:2817-25 pubmed publisher

product information

master code :

MAB6321

SKU :

MAB6321-100

product name :

Human CD40/TNFRSF5 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human CD40/TNFRSF5 Antibody from R&D Systems is a mouse monoclonal antibody to CD40/TNFRSF5. This antibody reacts with human,mouse. The Human CD40/TNFRSF5 Antibody has been validated for the following applications: Bioassay,Stimulation,Flow Cytometry,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Agonist Activity,Immunocytochemistry,CyTOF-ready.

target :

CD40/TNFRSF5

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

82111

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human CD40/TNFRSF5, Glu21-Arg193, Accession # P25942

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human CD40/TNFRSF5 in direct ELISAs and Western blots. In direct ELISAs, does not cross-react with recombinant human (rh) 4-1BB, rhCD27, rhCD30, recombinant mouse CD40, rhDR3, rhDR6, rhEDAR, rhFas, rhGITR, rhHVEM, rhLTR▀, rhNGF R, rhOPG, rhRANK, rhTAJ, rhTNF RI, or rhTNF RII.

gene symbol :

CD40

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

CD40/TNFRSF5 antibody in Human PBMCs by Immunocytochemistry (ICC).

accessionNumbers :

P25942

applications :

Stimulation,Flow Cytometry,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Agonist Activity,Immunocytochemistry,CyTOF-ready

USD :

479 USD

alt names :

B cell surface antigen CD40, B-cell surface antigen CD40, Bp50B cell-associated molecule, CD40, CD40 antigen, CD40 molecule, TNF receptor superfamily member 5, CD40 type II isoform, CD40L receptor, CDw40, MGC9013, nerve growth factor receptor-related B-lymphocyte activation molecule, p50, TNFRSF5, TNFRSF5CD40 antigen (TNF receptor superfamily member 5), tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily, member 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage