Human gp130 Antibody | R&D Systems MAB628-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human gp130 Antibody

catalog :

MAB628-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

28105

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 1a	Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
	Sk x142 adanowska K, Bloch Y, Strand J, White K, Hua J, Aldridge D, et al. Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep. 2022;41:111490 pubmed publisher
	Widjaja A, Viswanathan S, Jinrui D, Singh B, Tan J, Wei Ting J, et al. Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts. Front Mol Biosci. 2021;8:740650 pubmed publisher
	Nayar S, Morrison J, Giri M, Gettler K, Chuang L, Walker L, et al. A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease. Nature. 2021;593:275-281 pubmed publisher
	Zimmerlin L, Park T, Huo J, Verma K, Pather S, Talbot C, et al. Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development. 2016;143:4368-4380 pubmed
	Abir R, Fisch B, Jin S, Barnnet M, Freimann S, van den Hurk R, et al. Immunocytochemical detection and RT-PCR expression of leukaemia inhibitory factor and its receptor in human fetal and adult ovaries. Mol Hum Reprod. 2004;10:313-9 pubmed

product information

master code :

MAB628

SKU :

MAB628-100

product name :

Human gp130 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human gp130 Antibody from R&D Systems is a mouse monoclonal antibody to gp130/CD130. This antibody reacts with human. The Human gp130 Antibody has been validated for the following applications: Neutralization,Immunohistochemistry-Frozen,Immunohistochemistry,ELISA Capture (Matched Antibody Pair).

target :

gp130

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

28105

conjugate :

Unconjugated

host :

Mouse

immunogen :

Sf 21-derived recombinant human gp130 extracellular domain, Leu24-Glu619 (Glu619-Asp, predicted), Accession # P40189

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human gp130 in ELISAs. In sandwich immunoassays, no significant cross-reactivity or interference with recombinant human (rh) CNTF, rhIL-6, rhIL-6 R, recombinant mouse (rm) IL-6, rhIL-11, rhLIF, rhLIF R, rmLIF, or rhOSM is observed. This antibody blocks the human gp130-mediated bioactivities induced by IL-6, IL-11, LIF, OSM, and CNTF.

gene symbol :

IL6ST

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

gp130 antibody in Human Pancreas Tissue by Immunohistochemistry (IHC-P).

accessionNumbers :

P40189

applications :

Neutralization,Immunohistochemistry-Frozen,Immunohistochemistry,ELISA Capture (Matched Antibody Pair)

USD :

459 USD

alt names :

CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage