Human TRANCE/TNFSF11/RANK L Antibody | R&D Systems MAB626-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TRANCE/TNFSF11/RANK L Antibody

catalog :

MAB626-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

70525

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 12

Reference
Fern xe1 ndez Vallone V, Borzone F, Martinez L, Giorello M, Choi H, Dimase F, et al. Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients. Front Oncol. 2023;13:1073793 pubmed publisher
Gomes I, de Almeida B, Dâmaso S, Mansinho A, Correia I, Henriques S, et al. Expression of receptor activator of NFkB (RANK) drives stemness and resistance to therapy in ER+HER2- breast cancer. Oncotarget. 2020;11:1714-1728 pubmed publisher
Moonen C, de Vries T, Rijkschroeff P, Poubelle P, Nicu E, Loos B. The Possible Role of Neutrophils in the Induction of Osteoclastogenesis. J Immunol Res. 2019;2019:8672604 pubmed publisher
Ferguson J, Wilcock D, McEntegart S, Badrock A, Levesque M, Dummer R, et al. Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival. Pigment Cell Melanoma Res. 2019;: pubmed publisher
Kim H, Kim K, Kim B, Cho M, Lee S. The effect of vascular endothelial growth factor on osteoclastogenesis in rheumatoid arthritis. PLoS ONE. 2015;10:e0124909 pubmed publisher
Takeshita H, Kitano M, Iwasaki T, Kitano S, Tsunemi S, Sato C, et al. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-?B ligand (RANKL) expression in rheumatoid arthritis. Biochem Biophys Res Commun. 2012;419:154-9 pubmed publisher
Amiable N, Tat S, Lajeunesse D, Duval N, Pelletier J, Martel Pelletier J, et al. Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone. 2009;44:1143-50 pubmed publisher
Gendron S, Boisvert M, Chetoui N, Aoudjit F. Alpha1beta1 integrin and interleukin-7 receptor up-regulate the expression of RANKL in human T cells and enhance their osteoclastogenic function. Immunology. 2008;125:359-69 pubmed publisher
Lee N, Smolarz A, Olson S, David O, Reiser J, Kutner R, et al. A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies. Br J Cancer. 2007;97:1552-9 pubmed
Makrygiannakis D, af Klint E, Catrina S, Botusan I, Klareskog E, Klareskog L, et al. Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis. Arthritis Rheum. 2006;54:1463-72 pubmed
Fonseca J, Cortez Dias N, Francisco A, Sobral M, Canhao H, Resende C, et al. Inflammatory cell infiltrate and RANKL/OPG expression in rheumatoid synovium: comparison with other inflammatory arthropathies and correlation with outcome. Clin Exp Rheumatol. 2005;23:185-92 pubmed
Mandelin J, Li T, Hukkanen M, Liljeström M, Salo J, Santavirta S, et al. Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K. J Rheumatol. 2005;32:713-20 pubmed

product information

brand :

R&D Systems

master code :

MAB626

SKU :

MAB626-100

product name :

Human TRANCE/TNFSF11/RANK L Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human TRANCE/TNFSF11/RANK L Antibody from R&D Systems is a mouse monoclonal antibody to TRANCE/TNFSF11/RANK L. This antibody reacts with human. The Human TRANCE/TNFSF11/RANK L Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

TRANCE/TNFSF11/RANK L

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

70525

conjugate :

Unconjugated

dilution :

Immunohistochemistry 8-25 ug/mL, Neutralization 0.8-2.5 ug/mL

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TRANCE/TNFSF11/RANK L, Gly136-Asp317 (Ala194Gly), Accession # O14788

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human TRANCE/TNFSF11/RANK L in direct ELISAs. No cross-reactivity with recombinant mouse TRANCE is observed.

gene symbol :

TNFSF11

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Osteoclast-Like Cell Formation Induced by TRANCE/TNFSF11/RANK L and Neutralization by Human TRANCE/TNFSF11/RANK L Antibody.

accessionNumbers :

O14788

applications :

Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

469 USD

alt names :

CD254, CD254 antigen, ODF, OPGL, OPGLOPTB2, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK L, RANKL, RANKLreceptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCEODFhRANKL2, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand superfamily member 11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage