Human TNF RI/TNFRSF1A Antibody | R&D Systems MAB625-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TNF RI/TNFRSF1A Antibody

catalog :

MAB625-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

519 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

16805

reactivity :

human

application :

western blot, ELISA, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 28

Reference
Ben Khemis M, Liu D, Pintard C, Song Z, Hurtado Nedelec M, Marie J, et al. TNFα counteracts interleukin-10 anti-inflammatory pathway through the NOX2-Lyn-SHP-1 axis in human monocytes. Redox Biol. 2023;67:102898 pubmed publisher
Menevse A, Ammer L, Vollmann Zwerenz A, Kupczyk M, Lorenz J, Weidner L, et al. TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma. Acta Neuropathol Commun. 2023;11:75 pubmed publisher
Baram T, Oren N, Erlichman N, Meshel T, Ben Baruch A. Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Rao T, Beggs R, Ankenbauer K, Hwang J, Ma V, Salaita K, et al. ST6Gal-I-mediated sialylation of the epidermal growth factor receptor modulates cell mechanics and enhances invasion. J Biol Chem. 2022;298:101726 pubmed publisher
Zhu W, Qiu Q, Luo H, Zhang F, Wu J, Zhu X, et al. High Glucose Exacerbates TNF-α-Induced Proliferative Inhibition in Human Periodontal Ligament Stem Cells through Upregulation and Activation of TNF Receptor 1. Stem Cells Int. 2020;2020:4910767 pubmed publisher
Ahmad R, Kochumon S, Chandy B, Shenouda S, Koshy M, Hasan A, et al. TNF-α Drives the CCL4 Expression in Human Monocytic Cells: Involvement of the SAPK/JNK and NF-κB Signaling Pathways. Cell Physiol Biochem. 2019;52:908-921 pubmed publisher
Bin L, Li X, Richers B, Streib J, Hu J, Taylor P, et al. Ankyrin repeat domain 1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum. J Allergy Clin Immunol. 2018;141:2085-2093.e1 pubmed publisher
Yeap W, Wong K, Shimasaki N, Teo E, Quek J, Yong H, et al. CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. Sci Rep. 2016;6:34310 pubmed publisher
Steeland S, PuimÃ¨ge L, Vandenbroucke R, Van Hauwermeiren F, Haustraete J, Devoogdt N, et al. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1. J Biol Chem. 2015;290:4022-37 pubmed publisher
Loosbroock C, Hunter K. Inhibiting TNF-Î± signaling does not attenuate induction of endotoxin tolerance. J Inflamm Res. 2014;7:159-67 pubmed publisher
Ueda M, Fujisawa T, Ono M, Hara E, Pham H, Nakajima R, et al. A short-term treatment with tumor necrosis factor-alpha enhances stem cell phenotype of human dental pulp cells. Stem Cell Res Ther. 2014;5:31 pubmed publisher
Denoyer A, Godefroy D, Celerier I, Frugier J, Riancho L, Baudouin F, et al. CX3CL1 expression in the conjunctiva is involved in immune cell trafficking during toxic ocular surface inflammation. Mucosal Immunol. 2012;5:702-11 pubmed publisher
Zhao X, Qureshi F, Eastman P, Manning W, Alexander C, Robinson W, et al. Pre-analytical effects of blood sampling and handling in quantitative immunoassays for rheumatoid arthritis. J Immunol Methods. 2012;378:72-80 pubmed publisher
Bastarache J, Sebag S, Grove B, Ware L. Interferon-? and tumor necrosis factor-? act synergistically to up-regulate tissue factor in alveolar epithelial cells. Exp Lung Res. 2011;37:509-17 pubmed publisher
Turner Brannen E, Choi K, Arsenault R, El Gabalawy H, Napper S, Mookherjee N. Inflammatory cytokines IL-32 and IL-17 have common signaling intermediates despite differential dependence on TNF-receptor 1. J Immunol. 2011;186:7127-35 pubmed publisher
Krausgruber T, Saliba D, Ryzhakov G, Lanfrancotti A, Blazek K, Udalova I. IRF5 is required for late-phase TNF secretion by human dendritic cells. Blood. 2010;115:4421-30 pubmed publisher
Hu H, Kwun J, Aizenstein B, Knechtle S. Noninvasive detection of acute and chronic injuries in human renal transplant by elevation of multiple cytokines/chemokines in urine. Transplantation. 2009;87:1814-20 pubmed publisher
Emsley H, Smith C, Gavin C, Georgiou R, Vail A, Barberan E, et al. Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol. 2007;7:5 pubmed
Lee S, Cherla R, Tesh V. Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1. Infect Immun. 2007;75:1291-302 pubmed
Edwards J, Sun S, Locklin R, Shipman C, Adamopoulos I, Athanasou N, et al. LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis. Arthritis Rheum. 2006;54:1451-62 pubmed
Mozaffarian D, Rimm E, King I, Lawler R, McDonald G, Levy W. trans fatty acids and systemic inflammation in heart failure. Am J Clin Nutr. 2004;80:1521-5 pubmed
Ricci Vitiani L, Pedini F, Mollinari C, Condorelli G, Bonci D, Bez A, et al. Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death. J Exp Med. 2004;200:1257-66 pubmed
Chopin V, Slomianny C, Hondermarck H, Le Bourhis X. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Exp Cell Res. 2004;298:560-73 pubmed
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product information

master code :

MAB625

SKU :

MAB625-100

product name :

Human TNF RI/TNFRSF1A Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human TNF RI/TNFRSF1A Antibody from R&D Systems is a mouse monoclonal antibody to TNF RI/TNFRSF1A. This antibody reacts with human. The Human TNF RI/TNFRSF1A Antibody has been validated for the following applications: Neutralization,Antibody Array Development,Array Development,ELISA Development,ELISA Development (Capture),Neutralizing,Flow Cytometry,Western Blot,Functional Assay,ELISA Capture,ELISA Capture (Matched Antibody Pair).

target :

TNF RI/TNFRSF1A

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

16805

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human TNF RI/TNFRSF1A, Extracellular domain

isotype :

IgG1

purity :

Protein A or G purified from ascites

species :

Human

specificity :

Detects human TNF RI/TNFRSF1A in ELISAs and Western blots. In sandwich immunoassays, no significant cross-reactivity or interference with recombinant human (rh) TGF-alpha , hTGF┐▀1, porcine (p) TGF┐▀1, rhTGF┐▀1, pTGF┐▀1.2, pTGF┐▀2, recombinant chicken TGF┐▀3, rhTGF┐▀3, recombinant amphibian TGF┐▀5, rhTNF┐▀, or rhTNF RII is observed.

gene symbol :

TNFRSF1A

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

TNF RI/TNFRSF1A Inhibition of TNF-a-induced Cytotoxicity and Neutralization by Human TNF RI/TNFRSF1A Antibody.

applications :

Antibody Array Development,Array Development,ELISA Development,ELISA Development (Capture),Neutralizing,Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture,ELISA Capture (Matched Antibody Pair)

USD :

519 USD

alt names :

CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage