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company name :
R&D Systems
product type :
antibody
product name :
Human Caspase-1 Antibody
catalog :
MAB6215
quantity :
100 ug (also 25 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
661228
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 19
Reference
Li H, Zhu X, Xu J, Li L, Kan W, Bao H, et al. The FXR mediated anti-depression effect of CDCA underpinned its therapeutic potentiation for MDD. Int Immunopharmacol. 2023;115:109626 pubmed publisher
D xed az Garc xed a E, Nanwani Nanwani K, Garc xed a Tovar S, Alfaro E, L xf3 pez Collazo E, Quintana D xed az M, et al. NLRP3 Inflammasome Overactivation in Patients with Aneurysmal Subarachnoid Hemorrhage. Transl Stroke Res. 2023;14:334-346 pubmed publisher
Karki R, Lee S, Mall R, Pandian N, Wang Y, Sharma B, et al. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection. Sci Immunol. 2022;:eabo6294 pubmed publisher
Kung Y, Chiang H, Li M, Gong Y, Chiu H, Hung C, et al. Acyl-Coenzyme A Synthetase Long-Chain Family Member 4 Is Involved in Viral Replication Organelle Formation and Facilitates Virus Replication via Ferroptosis. MBio. 2022;13:e0271721 pubmed publisher
Lee S, Karki R, Wang Y, Nguyen L, Kalathur R, Kanneganti T. AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021;597:415-419 pubmed publisher
Lee S, Ishitsuka A, Kuroki T, Lin Y, Shibuya A, Hongu T, et al. Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes. JCI Insight. 2021;6: pubmed publisher
Read S, Gloss B, Liddle C, George J, Ahlenstiel G. Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis. J Inflamm Res. 2021;14:1257-1270 pubmed publisher
Posta N, Csosz E, Oros M, Pethő D, Potor L, Kalló G, et al. Hemoglobin oxidation generates globin-derived peptides in atherosclerotic lesions and intraventricular hemorrhage of the brain, provoking endothelial dysfunction. Lab Invest. 2020;100:986-1002 pubmed publisher
Wang Z, Zhou H, Zheng H, Zhou X, Shen G, Teng X, et al. Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation. Autophagy. 2021;17:529-552 pubmed publisher
Pires S, Parker D. IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms. Eur J Immunol. 2018;48:1707-1716 pubmed publisher
Lee S, Hirohama M, Noguchi M, Nagata K, Kawaguchi A. Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner. J Virol. 2018;92: pubmed publisher
Chambers S, O Neill C, Guduric Fuchs J, McLoughlin K, Liew A, Egan A, et al. The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1β. Stem Cells. 2018;36:834-843 pubmed publisher
Bednash J, Weathington N, Londino J, Rojas M, Gulick D, Fort R, et al. Targeting the deubiquitinase STAMBP inhibits NALP7 inflammasome activity. Nat Commun. 2017;8:15203 pubmed publisher
Zhang H, Luo J, Alcorn J, Chen K, Fan S, Pilewski J, et al. AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality. J Immunol. 2017;198:4383-4393 pubmed publisher
Plazyo O, Romero R, Unkel R, Balancio A, Mial T, Xu Y, et al. HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome. Biol Reprod. 2016;95:130 pubmed publisher
Shamaa O, Mitra S, Gavrilin M, Wewers M. Monocyte Caspase-1 Is Released in a Stable, Active High Molecular Weight Complex Distinct from the Unstable Cell Lysate-Activated Caspase-1. PLoS ONE. 2015;10:e0142203 pubmed publisher
Zhao T, Gao J, Van J, To E, Wang A, Cao S, et al. Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye. J Neuroinflammation. 2015;12:121 pubmed publisher
Liu R, Wang A, To E, Gao J, Cao S, Cui J, et al. Vinpocetine inhibits amyloid-beta induced activation of NF-?B, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells. Exp Eye Res. 2014;127:49-58 pubmed publisher
Qin M, Pirouz A, Kim M, Krutzik S, Garban H, Kim J. Propionibacterium acnes Induces IL-1? secretion via the NLRP3 inflammasome in human monocytes. J Invest Dermatol. 2014;134:381-388 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB6215
SKU :
MAB6215
product name :
Human Caspase-1 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Caspase-1 Antibody from R&D Systems is a mouse monoclonal antibody to Caspase-1. This antibody reacts with human,mouse,primate - cercopithecus aethiops (african green monkey),rat,transgenic mouse. The Human Caspase-1 Antibody has been validated for the following applications: Western Blot,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunocytochemistry.
target :
Caspase-1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
661228
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunocytochemistry 8-25 ug/mL
host :
Mouse
immunogen :
E.coli -derived recombinant human Caspase-1, Asn120-Asp297, Accession # P29466
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Primate - Cercopithecus aethiops (African Green Monkey),Rat,Transgenic Mouse
specificity :
Detects human Caspase-1 in direct ELISAs and Western blots.
gene symbol :
CASP1
top caption :
Detection of Human, Mouse, and Rat Caspase-1 antibody by Western Blot.
accessionNumbers :
P29466
applications :
Immunocytochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin
USD :
469 USD
alt names :
CASP1, CASP-1, CASP1 nirs variant 1, caspase 1, apoptosis-related cysteine peptidase, caspase-1, Caspase1, Caspase-1 subunit p10, Caspase-1 subunit p20, EC 3.4.22.36, EC:3.4.22.36, ICE, IL-1 beta-converting enzyme, IL1BC, IL-1BC, IL1BCE, IL1B-convertase, interleukin 1, beta, convertase, interleukin 1-B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.