Human CD40 Ligand/TNFSF5 Antibody | R&D Systems MAB617-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CD40 Ligand/TNFSF5 Antibody

catalog :

MAB617-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

40804

reactivity :

human

application :

western blot, immunohistochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 7

Reference
Shankar S, Stolp J, Juvet S, Beckett J, Macklin P, Issa F, et al. Ex vivo-expanded human CD19+TIM-1+ regulatory B cells suppress immune responses in vivo and are dependent upon the TIM-1/STAT3 axis. Nat Commun. 2022;13:3121 pubmed publisher
Buchholz D, Carroll T, Kocabas A, Zhu X, Behesti H, Faust P, et al. Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics. Proc Natl Acad Sci U S A. 2020;117:15085-15095 pubmed publisher
Bojadzic D, Buchwald P. CD40-targeting KGYY15 peptides do not efficiently block the CD40-CD40L interaction. Diabetologia. 2019;62:2158-2160 pubmed publisher
Bojadzic D, Chen J, Alcazar O, Buchwald P. Design, Synthesis, and Evaluation of Novel Immunomodulatory Small Molecules Targeting the CD40⁻CD154 Costimulatory Protein-Protein Interaction. Molecules. 2018;23: pubmed publisher
Sun C, Feng S, Cao Z, Bei J, Chen Q, Zhao W, et al. Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis. Cell Physiol Biochem. 2017;41:2319-2332 pubmed publisher
Maniar A, Zhang X, Lin W, Gastman B, Pauza C, Strome S, et al. Human gammadelta T lymphocytes induce robust NK cell-mediated antitumor cytotoxicity through CD137 engagement. Blood. 2010;116:1726-33 pubmed publisher
Liu T, Uemura Y, Suzuki M, Narita Y, Hirata S, Ohyama H, et al. Distinct subsets of human invariant NKT cells differentially regulate T helper responses via dendritic cells. Eur J Immunol. 2008;38:1012-23 pubmed publisher

product information

master code :

MAB617

SKU :

MAB617-100

product name :

Human CD40 Ligand/TNFSF5 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human CD40 Ligand/TNFSF5 Antibody from R&D Systems is a mouse monoclonal antibody to CD40 Ligand/TNFSF5. This antibody reacts with human. The Human CD40 Ligand/TNFSF5 Antibody has been validated for the following applications: Bioassay,Blocking,Neutralization,Immunohistochemistry,Flow Cytometry,Western Blot,Blockade of Receptor-ligand Interaction,CyTOF-ready.

target :

CD40 Ligand/TNFSF5

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

40804

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human CD40 Ligand/TNFSF5, Leu50-Leu261, Accession # P29965

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human CD40 Ligand/TNFSF5 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human (rh) CD27 Ligand, rhCD30 Ligand, or recombinant mouse CD40 Ligand is observed.

gene symbol :

CD40LG

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

CD40 Ligand/TNFSF5 antibody in Human Tonsil by Immunohistochemistry (IHC-P).

accessionNumbers :

P29965

applications :

Bioassay,Blocking,Neutralization,Immunohistochemistry,Flow Cytometry,Western Blot,Blockade of Receptor-ligand Interaction,CyTOF-ready

USD :

479 USD

alt names :

CD154, CD154 antigen, CD40 antigen ligand, CD40 ligand, CD40L, CD40-L, CD40LG, CD40LIGM, gp39, hCD40L, HIGM1, T-B cell-activating molecule, T-BAM, T-cell antigen Gp39, TNF-related activation protein, TNFSF5, TNFSF5IMD3, TRAP, TRAPtumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome), tumor necrosis factor (ligand) superfamily member 5, Tumor necrosis factor ligand superfamily member 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage