| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry knockout validation; mouse; 1:300; loading ...; fig 6a
- flow cytometry; mouse; loading ...; fig 6b
| Hagberg C, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina I, et al. Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity. Cell Rep. 2018;24:2746-2756.e5 pubmed publisher |
- western blot; mouse; 0.5 ug/ml; loading ...; fig 5b
| Takahashi H, Yang G, Yoneshiro T, Abe Y, Ito R, Yang C, et al. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis. Nat Commun. 2022;13:5715 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2l, 6a
| Liu W, Zhou H, Wang H, Zhang Q, Zhang R, Willard B, et al. IL-1R-IRAKM-Slc25a1 signaling axis reprograms lipogenesis in adipocytes to promote diet-induced obesity in mice. Nat Commun. 2022;13:2748 pubmed publisher |
- western blot; mouse; loading ...; fig s3f
| Emmett M, Lim H, Jager J, Richter H, Adlanmerini M, Peed L, et al. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. 2017;546:544-548 pubmed publisher |
- western blot; human; 1:1000; fig 2
| Lee M, Goralczyk A, Kriszt R, Ang X, Badowski C, Li Y, et al. ECM microenvironment unlocks brown adipogenic potential of adult human bone marrow-derived MSCs. Sci Rep. 2016;6:21173 pubmed publisher |
- immunohistochemistry; mouse; 1:1000; fig 1c
- western blot; mouse; fig 2h
| Stine R, Shapira S, Lim H, Ishibashi J, Harms M, Won K, et al. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue. Mol Metab. 2016;5:57-65 pubmed publisher |
| Moisan A, Lee Y, Zhang J, Hudak C, Meyer C, Prummer M, et al. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015;17:57-67 pubmed publisher |
- immunohistochemistry; mouse
| Fu T, Seok S, Choi S, Huang Z, Suino Powell K, Xu H, et al. MicroRNA 34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte fibroblast growth factor 21 signaling and SIRT1 function. Mol Cell Biol. 2014;34:4130-42 pubmed publisher |
| Ellis C, Tero B, Potts C, Malka K, Yang X, Hamilton J, et al. Cellular Characteristics and Protein Signatures of Human Adipose Tissues from Donors With or Without Advanced Coronary Artery Disease. Biomedicines. 2024;12: pubmed publisher |
| Song Y, Zhu M, Islam M, Gu W, Alim K, Cheng C, et al. Glutathione peroxidase 3 is essential for countering senescence in adipose remodelling by maintaining mitochondrial homeostasis. Redox Biol. 2024;77:103365 pubmed publisher |
| Chau P, Ryan E, Dalen K, Haugen F. Timing of acute cold exposure determines UCP1 and FGF21 expression - Possible interactions between the thermal environment, thermoregulatory responses, and peripheral clocks. J Therm Biol. 2024;124:103938 pubmed publisher |
| Takeda Y, Dai P. Functional roles of pantothenic acid, riboflavin, thiamine, and choline in adipocyte browning in chemically induced human brown adipocytes. Sci Rep. 2024;14:18252 pubmed publisher |
| Takeda Y, Yoshikawa T, Dai P. Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes. Sci Rep. 2024;14:10789 pubmed publisher |
| Herrnhold M, Hamp I, Plettenburg O, Jastroch M, Keuper M. Adverse bioenergetic effects of N-acyl amino acids in human adipocytes overshadow beneficial mitochondrial uncoupling. Redox Biol. 2023;66:102874 pubmed publisher |
| V xe1 mos A, Arianti R, Vinnai B, Alrifai R, Shaw A, P xf3 liska S, et al. Human abdominal subcutaneous-derived active beige adipocytes carrying FTO rs1421085 obesity-risk alleles exert lower thermogenic capacity. Front Cell Dev Biol. 2023;11:1155673 pubmed publisher |
| Coulter A, Greenway F, Zhang D, Ghosh S, Coulter C, James S, et al. Naringenin and β-carotene convert human white adipocytes to a beige phenotype and elevate hormone- stimulated lipolysis. Front Endocrinol (Lausanne). 2023;14:1148954 pubmed publisher |
| Janovska P, Zouhar P, Bardova K, Otahal J, Vrbacky M, Mracek T, et al. Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle. Mol Metab. 2023;69:101683 pubmed publisher |
| Choi K, Ko C, An S, Cho S, Rowland D, Kim J, et al. Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT. Mol Metab. 2023;69:101679 pubmed publisher |
| Yu X, Shi M, Wu Q, Wei W, Sun S, Zhu S. Identification of UCP1 and UCP2 as Potential Prognostic Markers in Breast Cancer: A Study Based on Immunohistochemical Analysis and Bioinformatics. Front Cell Dev Biol. 2022;10:891731 pubmed publisher |
| Takeda Y, Dai P. Chronic Fatty Acid Depletion Induces Uncoupling Protein 1 (UCP1) Expression to Coordinate Mitochondrial Inducible Proton Leak in a Human-Brown-Adipocyte Model. Cells. 2022;11: pubmed publisher |
| Deis J, Lin T, Bushman T, Chen X. Lipocalin 2 Deficiency Alters Prostaglandin Biosynthesis and mTOR Signaling Regulation of Thermogenesis and Lipid Metabolism in Adipocytes. Cells. 2022;11: pubmed publisher |
| Takeda Y, Dai P. Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts. Sci Rep. 2022;12:6612 pubmed publisher |
| Herbers E, Patrikoski M, Wagner A, Jokinen R, Hassinen A, Heinonen S, et al. Preventing White Adipocyte Browning during Differentiation In Vitro: The Effect of Differentiation Protocols on Metabolic and Mitochondrial Phenotypes. Stem Cells Int. 2022;2022:3308194 pubmed publisher |
| Jumabay M, Zhang L, Yao J, Bostr xf6 m K. Progenitor cells from brown adipose tissue undergo neurogenic differentiation. Sci Rep. 2022;12:5614 pubmed publisher |
| V xe1 mos A, Shaw A, Varga K, Csom xf3 s I, Mocs xe1 r G, Balajthy Z, et al. Mitophagy Mediates the Beige to White Transition of Human Primary Subcutaneous Adipocytes Ex Vivo. Pharmaceuticals (Basel). 2022;15: pubmed publisher |
| Choi K, Kim J, Kong X, Isik M, Zhang J, Lim H, et al. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Cell Rep. 2021;37:110104 pubmed publisher |
| B T xf3 th B, Barta Z, Barta x, F xe9 s xfc s L. Regulatory modules of human thermogenic adipocytes: functional genomics of large cohort and Meta-analysis derived marker-genes. BMC Genomics. 2021;22:886 pubmed publisher |
| Shaw A, T xf3 th B, Arianti R, Csom xf3 s I, P xf3 liska S, V xe1 mos A, et al. BMP7 Increases UCP1-Dependent and Independent Thermogenesis with a Unique Gene Expression Program in Human Neck Area Derived Adipocytes. Pharmaceuticals (Basel). 2021;14: pubmed publisher |
| Halbgebauer D, Roos J, Funcke J, Neubauer H, Hamilton B, Simon E, et al. Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2. Mol Metab. 2021;53:101336 pubmed publisher |
| Sostre Col xf3 n J, Uehara K, Garcia Whitlock A, Gavin M, Ishibashi J, Potthoff M, et al. Hepatic AKT orchestrates adipose tissue thermogenesis via FGF21-dependent and -independent mechanisms. Cell Rep. 2021;35:109128 pubmed publisher |
| Guan H, Zheng H, Zhang J, Xiang A, Li Y, Zheng H, et al. Secreted frizzled-related protein 4 promotes brown adipocyte differentiation. Exp Ther Med. 2021;21:637 pubmed publisher |
| Whitehead A, Krause F, Moran A, MacCannell A, Scragg J, McNally B, et al. Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun. 2021;12:1905 pubmed publisher |
| Takeda Y, Yoshikawa T, Dai P. Transcriptome analysis reveals brown adipogenic reprogramming in chemical compound-induced brown adipocytes converted from human dermal fibroblasts. Sci Rep. 2021;11:5061 pubmed publisher |
| Khatib Shahidi R, M Hoffmann J, Hedjazifar S, Bonnet L, K Baboota R, Heasman S, et al. Adult mice are unresponsive to AAV8-Gremlin1 gene therapy targeting the liver. PLoS ONE. 2021;16:e0247300 pubmed publisher |
| Chen L, Zhang J, Zou Y, Wang F, Li J, Sun F, et al. Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus. Cell Death Differ. 2021;28:1880-1899 pubmed publisher |
| Szatm xe1 ri T xf3 th M, Shaw A, Csom xf3 s I, Mocs xe1 r G, Fischer Posovszky P, Wabitsch M, et al. Thermogenic Activation Downregulates High Mitophagy Rate in Human Masked and Mature Beige Adipocytes. Int J Mol Sci. 2020;21: pubmed publisher |
| Diallo K, Dussault S, Noll C, Lopez A, Rivard A, Carpentier A, et al. 14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance. Mol Metab. 2020;41:101052 pubmed publisher |
| Angueira A, Shapira S, Ishibashi J, Sampat S, Sostre Colón J, Emmett M, et al. Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes. Cell Rep. 2020;30:2869-2878.e4 pubmed publisher |
| Takeda Y, Dai P. A developed serum-free medium and an optimized chemical cocktail for direct conversion of human dermal fibroblasts into brown adipocytes. Sci Rep. 2020;10:3775 pubmed publisher |
| Hoffmann J, Grünberg J, Hammarstedt A, Kroon T, Greiner T, Maurer S, et al. BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice. Mol Metab. 2020;32:15-26 pubmed publisher |
| Wang W, Ishibashi J, Trefely S, Shao M, Cowan A, Sakers A, et al. A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. Cell Metab. 2019;: pubmed publisher |
| Klusóczki Á, Veréb Z, Vámos A, Fischer Posovszky P, Wabitsch M, Bacso Z, et al. Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics. Sci Rep. 2019;9:5823 pubmed publisher |
| Harms M, Li Q, Lee S, Zhang C, Kull B, Hallen S, et al. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes. Cell Rep. 2019;27:213-225.e5 pubmed publisher |
| Chefetz I, Grimley E, Yang K, Hong L, Vinogradova E, Suciu R, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019;26:3061-3075.e6 pubmed publisher |
| Su S, Guntur A, Nguyen D, Fakory S, Doucette C, Leech C, et al. A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome. Cell Rep. 2018;25:3215-3228.e9 pubmed publisher |
| Rebello C, Greenway F, Lau F, Lin Y, Stephens J, Johnson W, et al. Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue. Obesity (Silver Spring). 2019;27:103-111 pubmed publisher |
| Stojanovska J, Lumeng C, Griffin C, Hernando D, Hoffmann U, Haft J, et al. Water-fat magnetic resonance imaging quantifies relative proportions of brown and white adipose tissues: ex-vivo experiments. J Med Imaging (Bellingham). 2018;5:024007 pubmed publisher |
| Boucher J, Robich M, Scott S, Yang X, Ryzhova L, Turner J, et al. Rab27a Regulates Human Perivascular Adipose Progenitor Cell Differentiation. Cardiovasc Drugs Ther. 2018;32:519-530 pubmed publisher |
| Restini C, Ismail A, Kumar R, Burnett R, Garver H, Fink G, et al. Renal perivascular adipose tissue: Form and function. Vascul Pharmacol. 2018;106:37-45 pubmed publisher |
| Zou Y, Lu P, Shi J, Liu W, Yang M, Zhao S, et al. IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk. EBioMedicine. 2017;24:64-75 pubmed publisher |
| Bal N, Singh S, Reis F, Maurya S, Pani S, Rowland L, et al. Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem. 2017;292:16616-16625 pubmed publisher |
| Takeda Y, Harada Y, Yoshikawa T, Dai P. Direct conversion of human fibroblasts to brown adipocytes by small chemical compounds. Sci Rep. 2017;7:4304 pubmed publisher |
| Shapira S, Lim H, Rajakumari S, Sakers A, Ishibashi J, Harms M, et al. EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Genes Dev. 2017;31:660-673 pubmed publisher |
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| Ambrosi T, Scialdone A, Graja A, Gohlke S, Jank A, Bocian C, et al. Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration. Cell Stem Cell. 2017;20:771-784.e6 pubmed publisher |
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