Human/Primate IL-2 Antibody | R&D Systems MAB602-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Primate IL-2 Antibody

catalog :

MAB602-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5355

reactivity :

human, mouse

application :

ELISA, immunocytochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 29

Reference
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Sukumar P, Deliorman M, Brimmo A, Alnemari R, Elsori D, Chen W, et al. Airplug-mediated isolation and centralization of single T cells in rectangular microwells for biosensing. Adv Ther (Weinh). 2020;3: pubmed publisher
Dwyer C, Arhontoulis D, Rangel Rivera G, Knochelmann H, Smith A, Wyatt M, et al. Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8+ T cells. Eur J Immunol. 2020;50:1386-1399 pubmed publisher
Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi A, et al. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours. Transplantation. 2020;104:e260-e270 pubmed publisher
Lee J, Lee E, Hong S, Kim D, Eunju O, Sprent J, et al. TCB2, a new anti-human interleukin-2 antibody, facilitates heterodimeric IL-2 receptor signaling and improves anti-tumor immunity. Oncoimmunology. 2020;9:1681869 pubmed publisher
Bryson B, Rosebrock T, Tafesse F, Itoh C, Nibasumba A, Babunovic G, et al. Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis. Nat Commun. 2019;10:2329 pubmed publisher
Caudana P, Núñez N, de la Rochere P, Pinto A, Denizeau J, Alonso R, et al. IL2/Anti-IL2 Complex Combined with CTLA-4, But Not PD-1, Blockade Rescues Antitumor NK Cell Function by Regulatory T-cell Modulation. Cancer Immunol Res. 2019;7:443-457 pubmed publisher
Trotta E, Bessette P, Silveria S, Ely L, Jude K, Le D, et al. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nat Med. 2018;24:1005-1014 pubmed publisher
Sultan H, Kumai T, Fesenkova V, Fan A, Wu J, Cho H, et al. Sustained Persistence of IL2 Signaling Enhances the Antitumor Effect of Peptide Vaccines through T-cell Expansion and Preventing PD-1 Inhibition. Cancer Immunol Res. 2018;6:617-627 pubmed publisher
Vazquez Lombardi R, Loetsch C, Zinkl D, Jackson J, Schofield P, Deenick E, et al. Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells. Nat Commun. 2017;8:15373 pubmed publisher
Whitfield S, Taylor C, Risdall J, Griffiths G, Jones J, Williamson E, et al. Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology. J Immunol. 2017;198:3989-3998 pubmed publisher
Chamoto K, Guo T, Scally S, Kagoya Y, Anczurowski M, Wang C, et al. Key Residues at Third CDR3? Position Impact Structure and Antigen Recognition of Human Invariant NK TCRs. J Immunol. 2017;198:1056-1065 pubmed publisher
Klevorn L, Berrien Elliott M, Yuan J, Kuehm L, Felock G, Crowe S, et al. Rescue of Tolerant CD8+ T Cells during Cancer Immunotherapy with IL2:Antibody Complexes. Cancer Immunol Res. 2016;4:1016-1026 pubmed
Schilbach K, Alkhaled M, Welker C, Eckert F, Blank G, Ziegler H, et al. Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation. Oncoimmunology. 2015;4:e1014760 pubmed
Rochman Y, Yukawa M, Kartashov A, Barski A. Functional characterization of human T cell hyporesponsiveness induced by CTLA4-Ig. PLoS ONE. 2015;10:e0122198 pubmed publisher
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Appleyard D, Chapin S, Doyle P. Multiplexed protein quantification with barcoded hydrogel microparticles. Anal Chem. 2011;83:193-9 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB602

SKU :

MAB602-100

product name :

Human/Primate IL-2 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human/Primate IL-2 Antibody from R&D Systems is a mouse monoclonal antibody to IL-2. This antibody reacts with human,mouse,primate,primate - papio anubis (olive baboon). The Human/Primate IL-2 Antibody has been validated for the following applications: ELISA Development,ELISA Development (Capture),Luminex Development,Stimulation,Neutralization,In vivo assay,ELISA Capture (Matched Antibody Pair),Immunocytochemistry.

target :

IL-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

5355

conjugate :

Unconjugated

dilution :

Immunocytochemistry 8-25 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

E. coli -derived recombinant human IL-2, Ala21-Thr153, Accession # NP_000577

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Primate,Primate - Papio anubis (Olive Baboon)

specificity :

Detects human and primate IL-2 in ELISAs. In sandwich immunoassays, no cross-reactivity with recombinant human (rh) IL-1 alpha , rhIL-1▀, rhIL-3, rhIL-4, rhIL-6, rhIL-7, rhIL-8, recombinant mouse (rm) IL-1▀, rmIL-2, rmIL-3, rmIL-4, rmIL-5, rmIL-6, or rmIL-7 is observed.

gene symbol :

IL2

top caption :

IL-2 antibody in Human PBMCs by Immunocytochemistry (ICC).

accessionNumbers :

NP_000577

applications :

ELISA Capture (Matched Antibody Pair),Immunocytochemistry,ELISA Development,ELISA Development (Capture),Luminex Development,Stimulation,In vivo assay,Neutralization

USD :

499 USD

alt names :

aldesleukin, IL2, IL-2, IL-2lymphokine, interleukin 2, interleukin-2, involved in regulation of T-cell clonal expansion, Proleukin, T cell growth factor, T-cell growth factor, TCGF

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage