Human/Mouse TGF┐▀ RI/ALK-5 Antibody | R&D Systems MAB5871 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse TGF┐▀ RI/ALK-5 Antibody

catalog :

MAB5871

quantity :

100 ug (also 25 ug)

price :

449 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

141231

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:10; loading ...; fig 6a western blot; mouse; loading ...; fig 6b	Chowdhury A, Hasselbach L, Echtermeyer F, Jyotsana N, Theilmeier G, Herzog C. Fibulin-6 regulates pro-fibrotic TGF-β responses in neonatal mouse ventricular cardiac fibroblasts. Sci Rep. 2017;7:42725 pubmed publisher
western blot; human; loading ...; fig 1a western blot; mouse; loading ...; fig 1a	Yin S, Fan Y, Zhang H, Zhao Z, Hao Y, Li J, et al. Differential TGF? pathway targeting by miR-122 in humans and mice affects liver cancer metastasis. Nat Commun. 2016;7:11012 pubmed publisher
immunocytochemistry; mouse; 1:100; fig 3	O Brien C, Bonanno L, Zhang H, Wyss Coray T. Beclin 1 regulates neuronal transforming growth factor-Î² signaling by mediating recycling of the type I receptor ALK5. Mol Neurodegener. 2015;10:69 pubmed publisher
western blot; mouse	Lamar J, Iyer V, DiPersio C. Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. J Invest Dermatol. 2008;128:575-86 pubmed
	Lei Z, Tang R, Wu Y, Mao C, Xue W, Shen J, et al. TGF-β1 induces PD-1 expression in macrophages through SMAD3/STAT3 cooperative signaling in chronic inflammation. JCI Insight. 2024;9: pubmed publisher
	Meng Z, Zhang S, Li W, Wang Y, Wang M, Liu X, et al. Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis. Eur Heart J. 2023;44:2763-2783 pubmed publisher
	Lee Y, Kim S, Jeong H, Kim K, Jeon D, Cho Y, et al. Role of Nox4 in Mitigating Inflammation and Fibrosis in Dextran Sulfate Sodium-Induced Colitis. Cell Mol Gastroenterol Hepatol. 2023;16:411-429 pubmed publisher
	Wu X, Zhang D, Qiao X, Zhang L, Cai X, Ji J, et al. Regulating the cell shift of endothelial cell-like myofibroblasts in pulmonary fibrosis. Eur Respir J. 2023;61: pubmed publisher
	Ju N, Hayashi H, Shimamura M, Baba S, Yoshida S, Morishita R, et al. Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice. Sci Rep. 2022;12:12474 pubmed publisher
	Gabitova Cornell L, Surumbayeva A, Peri S, Franco Barraza J, Restifo D, Weitz N, et al. Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer. Cancer Cell. 2020;38:567-583.e11 pubmed publisher
	Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, et al. Dendritic cell SIRT1-HIF1Î± axis programs the differentiation of CD4+ T cells through IL-12 and TGF-Î²1. Proc Natl Acad Sci U S A. 2015;112:E957-65 pubmed publisher

product information

master code :

MAB5871

SKU :

MAB5871

product name :

Human/Mouse TGF┐▀ RI/ALK-5 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse TGF¿ß RI/ALK-5 Antibody from R&D Systems is a rat monoclonal antibody to TGF-beta RI/ALK-5. This antibody reacts with human,mouse. The Human/Mouse TGF¿ß RI/ALK-5 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

TGF-beta RI/ALK-5

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

141231

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TGF┐▀ RI/ALK-5, Ala21-Glu121, Accession # BAA05023

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human and mouse TGF┐▀ RI/ALK-5 in Western blots. In direct ELISAs and Western blots, this antibody shows no cross-reactivity with rrMIS RII, rhTGF┐▀ RII, rhTGF┐▀ RIIb, or rhTGF┐▀ RIII.

gene symbol :

TGFBR1

top caption :

Detection of Mouse TGF-beta RI/ALK-5 by Western Blot

accessionNumbers :

BAA05023

applications :

Flow Cytometry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

449 USD

alt names :

AAT5, activin A receptor type II-like kinase, 53kD, activin A receptor type II-like kinase, 53kDa, Activin receptor-like kinase 5, ACVRLK4, ALK-5, ALK-5ALK5, EC 2.7.11, EC 2.7.11.30, LDS1A, LDS2A, Serine/threonine-protein kinase receptor R4, SKR4, TbetaR-I, TGFB1R1, TGF-beta receptor type I, TGF-beta receptor type-1, TGF-beta type I receptor, TGFbetaRI, TGFBR1, TGF-bRI, TGFR-1, transforming growth factor beta receptor I, transforming growth factor, beta receptor 1, transforming growth factor, beta receptor I (activin A receptor type II-likekinase, 53kD), Transforming growth factor-beta receptor type I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage