product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse TSLP Antibody
catalog :
MAB555-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
152614
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 25
Reference
Lee S, Kang B, Kamenyeva O, Ferreira T, Cho K, Khillan J, et al. Dermis resident macrophages orchestrate localized ILC2-eosinophil circuitries to maintain their M2-like properties and promote non-healing cutaneous leishmaniasis. Res Sq. 2023;: pubmed publisher
Shen Z, Luo W, Tan B, Nie K, Deng M, Wu S, et al. Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease. EBioMedicine. 2022;85:104285 pubmed publisher
Yao W, Germán B, Chraa D, Braud A, Hugel C, Meyer P, et al. Keratinocyte-derived cytokine TSLP promotes growth and metastasis of melanoma by regulating the tumor-associated immune microenvironment. JCI Insight. 2022;7: pubmed publisher
Lu Y, Huang Y, Li J, Huang J, Zhang L, Feng J, et al. Eosinophil extracellular traps drive asthma progression through neuro-immune signals. Nat Cell Biol. 2021;23:1060-1072 pubmed publisher
Majumder N, Goldsmith W, Kodali V, Velayutham M, Friend S, Khramtsov V, et al. Oxidant-induced epithelial alarmin pathway mediates lung inflammation and functional decline following ultrafine carbon and ozone inhalation co-exposure. Redox Biol. 2021;46:102092 pubmed publisher
Lee H, Lee H, Hur J, Kang H, Choi J, Rhee C, et al. Blockade of thymic stromal lymphopoietin and CRTH2 attenuates airway inflammation in a murine model of allergic asthma. Korean J Intern Med. 2020;35:619-629 pubmed publisher
Li S, Yi Z, Deng M, Scott M, Yang C, Li W, et al. TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway. JCI Insight. 2019;4: pubmed publisher
Han N, Moon P, Kim H, Jeong H. TSLP Exacerbates Septic Inflammation via Murine Double Minute 2 (MDM2) Signaling Pathway. J Clin Med. 2019;8: pubmed publisher
Lin S, Chou H, Chen C, Chiang B. Anti-thymic stromal lymphopoietin antibody suppresses airway remodeling in asthma through reduction of MMP and CTGF. Pediatr Res. 2018;: pubmed publisher
Verma M, Liu S, Michalec L, Sripada A, Gorska M, Alam R. Experimental asthma persists in IL-33 receptor knockout mice because of the emergence of thymic stromal lymphopoietin-driven IL-9+ and IL-13+ type 2 innate lymphoid cell subpopulations. J Allergy Clin Immunol. 2018;142:793-803.e8 pubmed publisher
Cao Y, Zhang E, Yang J, Yang Y, Yu J, Xiao Y, et al. Frontline Science: Nasal epithelial GM-CSF contributes to TLR5-mediated modulation of airway dendritic cells and subsequent IgA response. J Leukoc Biol. 2017;102:575-587 pubmed publisher
Hu Y, Dong H, Zou M, Huang C, Luo L, Yu C, et al. TSLP signaling blocking alleviates E-cadherin dysfunction of airway epithelium in a HDM-induced asthma model. Cell Immunol. 2017;315:56-63 pubmed publisher
Joo S, Fukuyama Y, Park E, Yuki Y, Kurashima Y, Ouchida R, et al. Critical role of TSLP-responsive mucosal dendritic cells in the induction of nasal antigen-specific IgA response. Mucosal Immunol. 2017;10:901-911 pubmed publisher
You H, Li R, Wei C, Chen S, Mao L, Zhang Z, et al. Thymic Stromal Lymphopoietin Neutralization Inhibits the Immune Adjuvant Effect of Di-(2-Ethylhexyl) Phthalate in Balb/c Mouse Asthma Model. PLoS ONE. 2016;11:e0159479 pubmed publisher
Yu M, Owens D, Ghosh S, Farber D. Conditional PDK1 Ablation Promotes Epidermal and T-Cell-Mediated Dysfunctions Leading to Inflammatory Skin Disease. J Invest Dermatol. 2015;135:2688-2696 pubmed publisher
Cipolat S, Hoste E, Natsuga K, Quist S, Watt F. Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility. elife. 2014;3:e01888 pubmed publisher
Taniguchi K, Arima K, Masuoka M, Ohta S, Shiraishi H, Ontsuka K, et al. Periostin controls keratinocyte proliferation and differentiation by interacting with the paracrine IL-1?/IL-6 loop. J Invest Dermatol. 2014;134:1295-1304 pubmed publisher
Chen Z, Zhang T, Li H, Chen F, Zou X, Ji J, et al. Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite. PLoS ONE. 2013;8:e51268 pubmed publisher
Oh M, Oh S, Yu J, Myers A, Leonard W, Liu Y, et al. IL-13 induces skin fibrosis in atopic dermatitis by thymic stromal lymphopoietin. J Immunol. 2011;186:7232-42 pubmed publisher
Olkhanud P, Rochman Y, Bodogai M, Malchinkhuu E, Wejksza K, Xu M, et al. Thymic stromal lymphopoietin is a key mediator of breast cancer progression. J Immunol. 2011;186:5656-62 pubmed publisher
Jung K, Tanaka A, Fujita H, Matsuda A, Oida K, Karasawa K, et al. Peroxisome proliferator-activated receptor ?-mediated suppression of dendritic cell function prevents the onset of atopic dermatitis in NC/Tnd mice. J Allergy Clin Immunol. 2011;127:420-429.e1-6 pubmed publisher
Miyata M, Nakamura Y, Shimokawa N, Ohnuma Y, Katoh R, Matsuoka S, et al. Thymic stromal lymphopoietin is a critical mediator of IL-13-driven allergic inflammation. Eur J Immunol. 2009;39:3078-83 pubmed publisher
Boehme S, Franz Bacon K, Chen E, Sasik R, Sprague L, Ly T, et al. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation. Int Immunol. 2009;21:81-93 pubmed publisher
Sokol C, Barton G, Farr A, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol. 2008;9:310-8 pubmed publisher
Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, et al. Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells. Blood. 2007;109:3706-12 pubmed
product information
master code :
MAB555
SKU :
MAB555-100
product name :
Mouse TSLP Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Mouse TSLP Antibody from R&D Systems is a rat monoclonal antibody to TSLP. This antibody reacts with mouse. The Mouse TSLP Antibody has been validated for the following applications: In vivo assay,Neutralizing,Flow Cytometry,Neutralization,Immunohistochemistry,Immunocytochemistry,Western Blot.
target :
TSLP
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
152614
conjugate :
Unconjugated
host :
Rat
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TSLP, Tyr20-Glu140, Accession # Q9JIE6
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse
specificity :
Detects mouse TSLP in Western blots.
gene symbol :
TSLP
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by TSLP and Neutralization by Mouse TSLP Antibody.
accessionNumbers :
Q9JIE6
applications :
Neutralizing,Flow Cytometry,Neutralization,Immunohistochemistry,In vivo assay,Immunocytochemistry,Western Blot
USD :
489 USD
alt names :
thymic stromal lymphopoietin
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.