Human/Mouse/Rat Glutathione Peroxidase 4/GPX4 Antibody | R&D Systems MAB5457 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat Glutathione Peroxidase 4/GPX4 Antibody

catalog :

MAB5457

quantity :

100 ug (also 25 ug)

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

565320

reactivity :

human, mouse, rat

application :

western blot

more info or order :

R&D Systems product webpage

citations: 23

Reference
Lei G, Mao C, Horbath A, Yan Y, Cai S, Yao J, et al. BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024;14:1476-1495 pubmed publisher
Chen Y, Guo X, Zeng Y, Mo X, Hong S, He H, et al. Oxidative stress induces mitochondrial iron overload and ferroptotic cell death. Sci Rep. 2023;13:15515 pubmed publisher
Kose T, Moreno Fernandez J, Vera Aviles M, Sharp P, Latunde Dada G. Ferulic acid protects HepG2 cells and mouse liver from iron-induced damage. Biochem Biophys Rep. 2023;35:101521 pubmed publisher
Radaelli E, Assenmacher C, Verrelle J, Banerjee E, Manero F, Khiati S, et al. Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis. elife. 2023;12: pubmed publisher
Mao C, Liu X, Yan Y, Olszewski K, Gan B. Reply to: DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition. Nature. 2023;619:E19-E23 pubmed publisher
Liu J, Lane S, Lall R, Russo M, Farrell L, Debreli Coskun M, et al. Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice. Sci Adv. 2022;8:eadc9245 pubmed publisher
Kose T, Sharp P, Latunde Dada G. Upregulation of Nrf2 Signalling and the Inhibition of Erastin-Induced Ferroptosis by Ferulic Acid in MIN6 Cells. Int J Mol Sci. 2022;23: pubmed publisher
Gao Z, Wang D, Zhang H, Yang J, Li M, Lu H, et al. An iron-deficient diet prevents alcohol- or diethylnitrosamine-induced acute hepatotoxicity in mice by inhibiting ferroptosis. Curr Res Food Sci. 2022;5:2171-2177 pubmed publisher
Pontel L, Bueno Costa A, Morellato A, Carvalho Santos J, Rou xe9 G, Esteller M. Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing. Redox Biol. 2022;55:102408 pubmed publisher
Wu S, Mao C, Kondiparthi L, Poyurovsky M, Olszewski K, Gan B. A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. Proc Natl Acad Sci U S A. 2022;119:e2121987119 pubmed publisher
Liu W, xd6 stberg N, Yalcınkaya M, Dou H, Endo Umeda K, Tang Y, et al. Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis. J Clin Invest. 2022;132: pubmed publisher
Koppula P, Lei G, Zhang Y, Yan Y, Mao C, Kondiparthi L, et al. A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers. Nat Commun. 2022;13:2206 pubmed publisher
Yao F, Deng Y, Zhao Y, Mei Y, Zhang Y, Liu X, et al. A targetable LIFR-NF-κB-LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis. Nat Commun. 2021;12:7333 pubmed publisher
Karmi O, Sohn Y, Zandalinas S, Rowland L, King S, Nechushtai R, et al. Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression. Free Radic Biol Med. 2021;176:92-104 pubmed publisher
Karmi O, Sohn Y, Marjault H, Israeli T, Leibowitz G, Ioannidis K, et al. A Combined Drug Treatment That Reduces Mitochondrial Iron and Reactive Oxygen Levels Recovers Insulin Secretion in NAF-1-Deficient Pancreatic Cells. Antioxidants (Basel). 2021;10: pubmed publisher
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, et al. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593:586-590 pubmed publisher
Zhang Y, Swanda R, Nie L, Liu X, Wang C, Lee H, et al. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021;12:1589 pubmed publisher
Lee H, Zandkarimi F, Zhang Y, Meena J, Kim J, Zhuang L, et al. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020;22:225-234 pubmed publisher
Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin S, et al. The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression. Cell Res. 2020;30:146-162 pubmed publisher
Gomaa A, Peng D, Chen Z, Soutto M, Abouelezz K, Corvalan A, et al. Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers. Sci Rep. 2019;9:16970 pubmed publisher
Hu C, Nydes M, Shanley K, Morales Pantoja I, Howard T, Bizzozero O. Reduced expression of the ferroptosis inhibitor glutathione peroxidase-4 in multiple sclerosis and experimental autoimmune encephalomyelitis. J Neurochem. 2019;148:426-439 pubmed publisher
Habermann K, Grünewald L, van Wijk S, Fulda S. Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death. Cell Death Dis. 2017;8:e3067 pubmed publisher
Schoeneberger H, Belz K, Schenk B, Fulda S. Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death. Oncogene. 2015;34:4032-43 pubmed publisher

product information

master code :

MAB5457

SKU :

MAB5457

product name :

Human/Mouse/Rat Glutathione Peroxidase 4/GPX4 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse/Rat Glutathione Peroxidase 4/GPX4 Antibody from R&D Systems is a mouse monoclonal antibody to Glutathione Peroxidase 4/GPX4. This antibody reacts with human,mouse,rat,transgenic mouse. The Human/Mouse/Rat Glutathione Peroxidase 4/GPX4 Antibody has been validated for the following applications: Western Blot.

target :

Glutathione Peroxidase 4/GPX4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

565320

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

E. coli -derived recombinant human Glutathione Peroxidase 4, Gly74-Phe168, Accession # P36969

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects endogenous human, mouse and rat GPX4 in Western blots.

gene symbol :

GPX4

top caption :

Detection of Human/Mouse/Rat Glutathione Peroxidase 4 antibody by Western Blot.

accessionNumbers :

P36969

applications :

Western Blot

USD :

449 USD

alt names :

EC 1.11.1, EC 1.11.1.12, Glutathione peroxidase 4, glutathione peroxidase 4 (phospholipid hydroperoxidase), GPx-4, GPX4, GSHPx-4, MCSP, PHGPx, PHGPxsnGPx, phospholipid hydroperoxidase, phospholipid hydroperoxide glutathione peroxidase, mitochondrial, snGPx, snPHGPx, sperm nucleus glutathione peroxidase

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage