product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Klotho Antibody
catalog :
MAB5334-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
775340
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, neutralization, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 3
Reference
The E, Zhai Y, Yao Q, Ao L, Fullerton D, Meng X. Molecular Interaction of Soluble Klotho with FGF23 in the Pathobiology of Aortic Valve Lesions Induced by Chronic Kidney Disease. Int J Biol Sci. 2024;20:3412-3425 pubmed publisher
Suk Kang J, Son S, Lee J, Lee S, Jeong A, Lee E, et al. Protective effects of klotho on palmitate-induced podocyte injury in diabetic nephropathy. PLoS ONE. 2021;16:e0250666 pubmed publisher
Zhong X, Jagarlapudi S, Weng Y, Ly M, Rouse J, McClure K, et al. Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease. J Biol Chem. 2020;295:3115-3133 pubmed publisher
product information
brand :
R&D Systems
catalog number base :
MAB5334
SKU :
MAB5334-100
product name :
Human Klotho Antibody
units size :
100 ug (also 25 ug, 500 ug)
description :
The Human Klotho Antibody from R&D Systems is a rat monoclonal antibody to Klotho. This antibody reacts with human,mouse,rat,transgenic mouse. The Human Klotho Antibody has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,Western Blot,Neutralization.
target :
Klotho
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Monoclonal
clone :
775340
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Klotho, Glu34-Ser981, Accession # Q9UEF7
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects human Klotho in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse (rm) Klotho (aa 35-982) is observed and no cross-reactivity with rmKlotho (aa 23-550), recombinant human (rh) Klotho beta (aa 53-997), or rhCytosolic beta-Glucosidase/GBA3 is observed.
gene symbol :
KL
endotoxin note :
<0.10 EU per 1 µg of the antibody by the LAL method.
top caption :
Cell Proliferation Induced by Klotho and Neutralization by Human Klotho Antibody.
accessionNumbers :
Q9UEF7
applications :
Immunohistochemistry,Immunoprecipitation,Western Blot,Neutralization
USD :
479 USD
alt names :
EC 3.2.1, EC 3.2.1.31, KL, klotho
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.