CCL17/TARC Antibody | R&D Systems MAB529-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

CCL17/TARC Antibody

catalog :

MAB529-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

442 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

110904

reactivity :

mouse

application :

ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 15

Reference
Deng S, Jin P, Sherchan P, Liu S, Cui Y, Huang L, et al. Recombinant CCL17-dependent CCR4 activation alleviates neuroinflammation and neuronal apoptosis through the PI3K/AKT/Foxo1 signaling pathway after ICH in mice. J Neuroinflammation. 2021;18:62 pubmed publisher
Lee M, Saleh R, Achuthan A, Fleetwood A, Forster I, Hamilton J, et al. CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis Res Ther. 2018;20:62 pubmed publisher
Cook A, Lee M, Saleh R, Khiew H, Christensen A, Achuthan A, et al. TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17. JCI Insight. 2018;3: pubmed publisher
Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, et al. RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo. Mol Ther. 2018;26:95-104 pubmed publisher
Thanabalasuriar A, Neupane A, Wang J, Krummel M, Kubes P. iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation. Cell Rep. 2016;16:3260-3272 pubmed publisher
Achuthan A, Cook A, Lee M, Saleh R, Khiew H, Chang M, et al. Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. J Clin Invest. 2016;126:3453-66 pubmed publisher
Santulli Marotto S, Boakye K, Lacy E, Wu S, Luongo J, Kavalkovich K, et al. Engagement of two distinct binding domains on CCL17 is required for signaling through CCR4 and establishment of localized inflammatory conditions in the lung. PLoS ONE. 2013;8:e81465 pubmed publisher
Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58:169-77 pubmed publisher
Specht S, Frank J, Alferink J, Dubben B, Layland L, Denece G, et al. CCL17 controls mast cells for the defense against filarial larval entry. J Immunol. 2011;186:4845-52 pubmed publisher
Kearley J, Buckland K, Mathie S, Lloyd C. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med. 2009;179:772-81 pubmed publisher
HENRY C, Ornelles D, Mitchell L, Brzoza Lewis K, Hiltbold E. IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17. J Immunol. 2008;181:8576-84 pubmed
Kearley J, Robinson D, Lloyd C. CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J Allergy Clin Immunol. 2008;122:617-24.e6 pubmed publisher
Meyer E, Wurbel M, Staton T, Pichavant M, Kan M, Savage P, et al. iNKT cells require CCR4 to localize to the airways and to induce airway hyperreactivity. J Immunol. 2007;179:4661-71 pubmed
Fujita H, Asahina A, Komine M, Tamaki K. The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell Immunol. 2007;245:70-9 pubmed
Bengtsson A, Ryan E, Giordano D, Magaletti D, Clark E. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood. 2004;104:1404-10 pubmed

image

image 1 :

Chemotaxis Induced by CCL17/TARC and Neutralization by Mouse CCL17/TARC Antibody.

product information

brand :

R&D Systems

master code :

MAB529

SKU :

MAB529-100

product name :

CCL17/TARC Antibody

description :

The Mouse CCL17/TARC Antibody from R&D Systems is a rat monoclonal antibody to CCL17/TARC. This antibody reacts with mouse. The Mouse CCL17/TARC Antibody has been validated for the following applications: Neutralization, ELISA Capture (Matched Antibody Pair).

target :

CCL17/TARC

category :

Primary Antibodies

sizes available :

100 ug (also 500 ug, 25 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

110904

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived Recombinant Mouse CCL17/TARC, Ala24-Pro93, Accession # Q9WUZ6

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse CCL17/TARC in ELISAs

gene symbol :

CCL17

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

Q9WUZ6

applications :

Neutralization, ELISA Capture (Matched Antibody Pair)

USD :

442 USD

alt names :

ABCD-2, CC chemokine TARC, C-C motif chemokine 17, chemokine (C-C motif) ligand 17, MGC138273, SCYA17, SCYA17MGC138271, small inducible cytokine subfamily A (Cys-Cys), member 17, Small-inducible cytokine A17, T cell-directed CC chemokine, TARC, TARCA-152E5.3, Thymus and activation-regulated chemokine

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage