Human MMP-13 Antibody | R&D Systems MAB511-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human MMP-13 Antibody

catalog :

MAB511-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

87512

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 24

Reference
Ro D, Cho G, Kim J, Min S, Yang H, Park H, et al. Selective targeting of dipeptidyl-peptidase 4 (DPP-4) positive senescent chondrocyte ameliorates osteoarthritis progression. Aging Cell. 2024;23:e14161 pubmed publisher
Koulicoff L, Heilman T, Vitanza L, Welter A, Jeneske H, O Quinn T, et al. Matrix metalloproteinase- 9 may contribute to collagen structure modification during postmortem aging of beef. Meat Sci. 2023;205:109321 pubmed publisher
Li P, Lv S, Jiang W, Si L, Liao B, Zhao G, et al. Exosomes derived from umbilical cord mesenchymal stem cells protect cartilage and regulate the polarization of macrophages in osteoarthritis. Ann Transl Med. 2022;10:976 pubmed publisher
Pellegrini E, Desando G, Petretta M, Cellamare A, Cristalli C, Pasello M, et al. A 3D Collagen-Based Bioprinted Model to Study Osteosarcoma Invasiveness and Drug Response. Polymers (Basel). 2022;14: pubmed publisher
Lindgren M, Rask G, Jonsson J, Berglund A, Lundin C, Jonsson P, et al. Type IV Collagen in Human Colorectal Liver Metastases-Cellular Origin and a Circulating Biomarker. Cancers (Basel). 2022;14: pubmed publisher
Oliveros Anerillas L, Kingham P, Lammi M, Wiberg M, Kelk P. Three-Dimensional Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Matrix Metallopeptidase 13 (MMP13) Expression in Type I Collagen Hydrogels. Int J Mol Sci. 2021;22: pubmed publisher
Ormsby R, Zelmer A, Yang D, Gunn N, Starczak Y, Kidd S, et al. Evidence for osteocyte-mediated bone-matrix degradation associated with periprosthetic joint infection (PJI). Eur Cell Mater. 2021;42:264-280 pubmed publisher
Park S, Arai Y, Bello A, Park H, Kim D, Park K, et al. SPRY4 acts as an indicator of osteoarthritis severity and regulates chondrocyte hypertrophy and ECM protease expression. NPJ Regen Med. 2021;6:56 pubmed publisher
Park J, Park H, Lee Y, Weon S, Kim Y, Yang J, et al. Blocking TNFα attenuates progressive cartilage matrix degradation in inflammatory arthritis. Exp Ther Med. 2021;22:808 pubmed publisher
Villalvilla A, Larra xf1 aga Vera A, Lamuedra A, P xe9 rez Baos S, L xf3 pez Reyes A, Herrero Beaumont G, et al. Modulation of the Inflammatory Process by Hypercholesterolemia in Osteoarthritis. Front Med (Lausanne). 2020;7:566250 pubmed publisher
Cassuto J, Folestad A, Göthlin J, Malchau H, Kärrholm J. Concerted actions by MMPs, ADAMTS and serine proteases during remodeling of the cartilage callus into bone during osseointegration of hip implants. Bone Rep. 2020;13:100715 pubmed publisher
Kim S, Jang S, Kim H, Chung S, Park J, Kuh H. Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture Model. Cancers (Basel). 2020;12: pubmed publisher
SÃ¡nchez C, Andahur E, Valenzuela R, CastellÃ³n E, FullÃ¡ J, Ramos C, et al. Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche. Oncotarget. 2016;7:3993-4008 pubmed publisher
Vincent Chong V, Salahshourifar I, Karen Ng L, Siow M, Kallarakkal T, Ramanathan A, et al. Overexpression of MMP13 is associated with clinical outcomes and poor prognosis in oral squamous cell carcinoma. ScientificWorldJournal. 2014;2014:897523 pubmed publisher
Orgaz J, Pandya P, Dalmeida R, Karagiannis P, Sanchez Laorden B, Viros A, et al. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun. 2014;5:4255 pubmed publisher
Nkyimbeng T, Ruppert C, Shiomi T, Dahal B, Lang G, Seeger W, et al. Pivotal role of matrix metalloproteinase 13 in extracellular matrix turnover in idiopathic pulmonary fibrosis. PLoS ONE. 2013;8:e73279 pubmed publisher
Nurmenniemi S, Kuvaja P, Lehtonen S, Tiuraniemi S, Alahuhta I, Mattila R, et al. Toll-like receptor 9 ligands enhance mesenchymal stem cell invasion and expression of matrix metalloprotease-13. Exp Cell Res. 2010;316:2676-82 pubmed publisher
Sendzik J, Shakibaei M, Schäfer Korting M, Lode H, Stahlmann R. Synergistic effects of dexamethasone and quinolones on human-derived tendon cells. Int J Antimicrob Agents. 2010;35:366-74 pubmed publisher
Cavallo C, Desando G, Facchini A, Grigolo B. Chondrocytes from patients with osteoarthritis express typical extracellular matrix molecules once grown onto a three-dimensional hyaluronan-based scaffold. J Biomed Mater Res A. 2010;93:86-95 pubmed publisher
Ohlund D, Ardnor B, Oman M, Naredi P, Sund M. Expression pattern and circulating levels of endostatin in patients with pancreas cancer. Int J Cancer. 2008;122:2805-10 pubmed publisher
Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan E, et al. Ecto-5'-nucleotidase (CD73) -mediated extracellular adenosine production plays a critical role in hepatic fibrosis. FASEB J. 2008;22:2263-72 pubmed publisher
Im H, Muddasani P, Natarajan V, Schmid T, Block J, Davis F, et al. Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes. J Biol Chem. 2007;282:11110-21 pubmed
Olivotto E, Vitellozzi R, Fernandez P, Falcieri E, Battistelli M, Burattini S, et al. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. J Cell Physiol. 2007;210:417-27 pubmed
Pelletier J, Boileau C, Brunet J, Boily M, Lajeunesse D, Reboul P, et al. The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone. 2004;34:527-38 pubmed

product information

master code :

MAB511

SKU :

MAB511-100

product name :

Human MMP-13 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human MMP-13 Antibody from R&D Systems is a mouse monoclonal antibody to MMP-13. This antibody reacts with bovine,canine,human,mouse,rabbit,rat. The Human MMP-13 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,ELISA Development,Neutralization,ELISA Detection,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Immunoaffinity Purification.

target :

MMP-13

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

87512

conjugate :

Unconjugated

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human MMP-13, Leu20-Cys471, Accession # P45452

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Bovine,Canine,Human,Mouse,Rabbit,Rat

specificity :

Detects human MMP-13 in direct ELISAs and Western blots. Detects both pro and active forms of human MMP-13 in Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human MMP-1, -2, -3, -7, -8, -9, -10, or -12 is observed.

gene symbol :

MMP13

top caption :

MMP-13 antibody in MDA-MB-231 Human Cell Line by Immunocytochemistry (ICC).

accessionNumbers :

P45452

applications :

Immunohistochemistry,Western Blot,ELISA Development,Neutralization,ELISA Detection,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation,Immunoaffinity Purification

USD :

459 USD

alt names :

CLG 3, CLG3EC 3.4.24, collagenase 3, EC 3.4.24.-, EC 3.4.24.22, EC 3.4.24.24, EC 3.4.24.35, EC 3.4.24.65, EC 3.4.24.7, MANDP1, matrix metallopeptidase 13 (collagenase 3), matrix metalloproteinase 13 (collagenase 3), Matrix metalloproteinase-13, MMP13, MMP-13

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage