product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Rat TNF-alpha Antibody
catalog :
MAB510-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
45418
reactivity :
human, rat
application :
western blot, ELISA, immunohistochemistry, neutralization, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 18
Reference
Selejan S, Linz D, Mauz M, Hohl M, Huynh A, Speer T, et al. Renal denervation reduces atrial remodeling in hypertensive rats with metabolic syndrome. Basic Res Cardiol. 2022;117:36 pubmed publisher
Tamura T, Sano M, Matsuoka T, Yoshizawa J, Yamamoto R, Katsumata Y, et al. Hydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model. Shock. 2020;54:377-385 pubmed publisher
Liu J, Liu Z, Liu G, Gao K, Zhou H, Zhao Y, et al. Spinal cord injury and its underlying mechanism in rats with temporal lobe epilepsy. Exp Ther Med. 2020;19:2103-2112 pubmed publisher
Oh S, Lee H, Ki Y, Kim S, Lim K, Jung K. Gabexate mesilate ameliorates the neuropathic pain in a rat model by inhibition of proinflammatory cytokines and nitric oxide pathway via suppression of nuclear factor-κB. Korean J Pain. 2020;33:30-39 pubmed publisher
Singh A, Jones O, Mockett B, Ohline S, Abraham W. Tumor Necrosis Factor-α-Mediated Metaplastic Inhibition of LTP Is Constitutively Engaged in an Alzheimer's Disease Model. J Neurosci. 2019;39:9083-9097 pubmed publisher
Jeong J, Chung Y, Jin B. Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress. Int J Mol Sci. 2019;20: pubmed publisher
Zhao Y, Zhang L, Han R, Si Y, Zhao Z. Intravenous injection of post-hemorrhagic shock mesenteric lymph induces multiple organ injury in rats. Exp Ther Med. 2019;17:1449-1455 pubmed publisher
Ganguly P, Honeycutt J, Rowe J, Demaestri C, Brenhouse H. Effects of early life stress on cocaine conditioning and AMPA receptor composition are sex-specific and driven by TNF. Brain Behav Immun. 2019;78:41-51 pubmed publisher
Chen Y, Zhao Q, Chen Q, Zhang Y, Shao B, Jin Y, et al. Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis. Mol Med Rep. 2018;17:5934-5939 pubmed publisher
Abd Ellatef G, Ahmed O, Abdel Reheim E, Abdel Hamid A. Ulva lactuca polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation. Breast Cancer (Dove Med Press). 2017;9:67-83 pubmed publisher
Ge Q, Wang S, Zheng Y. Systemic administration of an anti-tumor necrosis factor-alpha monoclonal antibody protects against endotoxin-induced uveitis in rats. Indian J Ophthalmol. 2016;64:873-877 pubmed publisher
Friedrich E, Washburn N. Transport patterns of anti-TNF-? in burn wounds: Therapeutic implications of hyaluronic acid conjugation. Biomaterials. 2017;114:10-22 pubmed publisher
Cao G, Gonzalez J, Muller A, Ottaviano G, Ambrosio G, Toblli J, et al. Beneficial Effect of Moderate Exercise in Kidney of Rat after Chronic Consumption of Cola Drinks. PLoS ONE. 2016;11:e0152461 pubmed publisher
Cheng H, Davis D, Hasheminassab S, Sioutas C, Morgan T, Finch C. Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro. J Neuroinflammation. 2016;13:19 pubmed publisher
Lim S, Park E, You B, Jung Y, Park A, Park S, et al. Neuronal synapse formation induced by microglia and interleukin 10. PLoS ONE. 2013;8:e81218 pubmed publisher
Russo T, Beanan J, Olson R, Macdonald U, Luke N, Gill S, et al. Rat pneumonia and soft-tissue infection models for the study of Acinetobacter baumannii biology. Infect Immun. 2008;76:3577-86 pubmed publisher
Roche M, Diamond M, Kelly J, Finn D. In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids. J Neuroimmunol. 2006;181:57-67 pubmed
Nagakawa Y, Williams G, Zheng Q, Tsuchida A, Aoki T, Montgomery R, et al. Oxidative mitochondrial DNA damage and deletion in hepatocytes of rejecting liver allografts in rats: role of TNF-alpha. Hepatology. 2005;42:208-15 pubmed
product information
master code :
MAB510
SKU :
MAB510-100
product name :
Rat TNF-alpha Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Rat TNF-alpha Antibody from R&D Systems is a mouse monoclonal antibody to TNF-alpha. This antibody reacts with rat. The Rat TNF-alpha Antibody has been validated for the following applications: Binding Assay,ELISA Development,ELISA Development (Capture),Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,In vivo assay,ELISA Capture (Matched Antibody Pair).
target :
TNF-alpha
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
45418
conjugate :
Unconjugated
host :
Mouse
immunogen :
E. coli -derived recombinant rat TNF-alpha , Accession # P16599
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Rat
specificity :
Detects rat TNF-alpha in ELISAs and Western blots. In ELISAs, this antibody shows less than 3% cross-reactivity with recombinant mouse (rm) TNF-alpha and less than 0.2% cross-reactivity with rhTNF-alpha , rpTNF-alpha , and rhTNF┐▀. In Western blots, this antibody shows 100% cross-reactivity with rmTNF-alpha and no cross-reactivity with rfeTNF-alpha .
gene symbol :
TNF
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Cytotoxicity Induced by TNF-a and Neutralization by Rat TNF-a Antibody.
accessionNumbers :
P16599
applications :
Binding Assay,ELISA Development,ELISA Development (Capture),Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,In vivo assay,ELISA Capture (Matched Antibody Pair)
USD :
479 USD
alt names :
APC1 protein, Cachectin, Cachetin, DIF, TNF, TNF, monocyte-derived, TNF-a, TNFA, TNFalpha, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFG1F, TNFSF1A, TNFSF2, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.