Human BMP-6 Antibody | R&D Systems MAB507-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human BMP-6 Antibody

catalog :

MAB507-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

74219

reactivity :

human, mouse

application :

western blot, ELISA, neutralization

more info or order :

R&D Systems product webpage

citations: 7

Reference
Koo J, Seong C, Parker R, Herrera A, Dwivedi B, Arthur R, et al. Live-Cell Invasive Phenotyping Uncovers ALK2 as a Therapeutic Target in LKB1-Mutant Lung Cancer. Cancer Res. 2024;84:3761-3771 pubmed publisher
Koo J, Seong C, Parker R, Dwivedi B, Arthur R, Dinasarapu A, et al. Live-cell invasive phenotyping uncovers the ALK2/BMP6 iron homeostasis pathway as a therapeutic vulnerability in LKB1-mutant lung cancer. bioRxiv. 2023;: pubmed publisher
Blanchette Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, et al. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. 2018;37:4013-4032 pubmed publisher
Wang C, Core A, Canali S, Zumbrennen Bullough K, Ozer S, Umans L, et al. Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice. Blood. 2017;130:73-83 pubmed publisher
Hurst L, Dunmore B, Long L, Crosby A, Al Lamki R, Deighton J, et al. TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling. Nat Commun. 2017;8:14079 pubmed publisher
Meynard D, Vaja V, Sun C, Corradini E, Chen S, Lopez Otin C, et al. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood. 2011;118:747-56 pubmed publisher
Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller E. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res. 2005;65:8274-85 pubmed

product information

master code :

MAB507

SKU :

MAB507-100

product name :

Human BMP-6 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human BMP-6 Antibody from R&D Systems is a mouse monoclonal antibody to BMP-6. This antibody reacts with human,mouse. The Human BMP-6 Antibody has been validated for the following applications: Neutralization,Western Blot,ELISA Capture (Matched Antibody Pair).

target :

BMP-6

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS and NaCl with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

74219

conjugate :

Unconjugated

host :

Mouse

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant human BMP-6, Arg296-His428, Accession # Q4VBA3

isotype :

IgG2b

purity :

Protein A or G purified from ascites

species :

Human,Mouse

specificity :

Detects human BMP-6 in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, or rhBMP-7 is observed.

gene symbol :

BMP6

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Alkaline Phosphatase Production Induced by BMP-6 and Neutralization by Human BMP-6 Antibody.

accessionNumbers :

Q4VBA3

applications :

Neutralization,Western Blot,ELISA Capture (Matched Antibody Pair)

USD :

489 USD

alt names :

BMP6, BMP-6, bone morphogenetic protein 6, vegetal related growth factor (TGFB-related), vegetal-related (TGFB related) cytokine, VG-1-R, VG-1-related protein, Vg1-related sequence, VGR, Vgr-1, VGR1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage