product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse BMPR-IB/ALK-6 Antibody
catalog :
MAB505-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
88614
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 11
Reference
Meng Z, Zhang S, Li W, Wang Y, Wang M, Liu X, et al. Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis. Eur Heart J. 2023;44:2763-2783 pubmed publisher
Li C, Meng X, Liu S, Li W, Zhang X, Zhou J, et al. Oocytes and hypoxanthine orchestrate the G2-M switch mechanism in ovarian granulosa cells. Development. 2020;147: pubmed publisher
Veschi V, Mangiapane L, Nicotra A, Di Franco S, Scavo E, Apuzzo T, et al. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant. Oncogene. 2020;39:987-1003 pubmed publisher
Ribeiro A, Freitas C, Matos L, Gouveia A, Gomes F, Silva Carvalho J, et al. Age-related expression of TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet. 2017;34:1121-1129 pubmed publisher
Whittle A, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, et al. Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans. Nat Commun. 2015;6:8951 pubmed publisher
Beckham J, Tuttle K, Tyler K. Reovirus activates transforming growth factor beta and bone morphogenetic protein signaling pathways in the central nervous system that contribute to neuronal survival following infection. J Virol. 2009;83:5035-45 pubmed publisher
Sengle G, Ono R, Lyons K, Bachinger H, Sakai L. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7. J Mol Biol. 2008;381:1025-39 pubmed publisher
Southwood M, Jeffery T, Yang X, Upton P, Hall S, Atkinson C, et al. Regulation of bone morphogenetic protein signalling in human pulmonary vascular development. J Pathol. 2008;214:85-95 pubmed
Alejandre Alcazar M, Kwapiszewska G, Reiss I, Amarie O, Marsh L, Sevilla Pérez J, et al. Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2007;292:L537-49 pubmed
Bleuming S, Kodach L, Garcia Leon M, Richel D, Peppelenbosch M, Reitsma P, et al. Altered bone morphogenetic protein signalling in the Helicobacter pylori-infected stomach. J Pathol. 2006;209:190-7 pubmed
Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller E. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res. 2005;65:8274-85 pubmed
product information
master code :
MAB505
SKU :
MAB505-100
product name :
Human/Mouse BMPR-IB/ALK-6 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human/Mouse BMPR-IB/ALK-6 Antibody from R&D Systems is a mouse monoclonal antibody to BMPR-IB/ALK-6. This antibody reacts with human,mouse. The Human/Mouse BMPR-IB/ALK-6 Antibody has been validated for the following applications: ELISA Development,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.
target :
BMPR-IB/ALK-6
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
88614
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human BMPR-IB/ALK-6, Lys14-Arg126, Accession # O00238
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human,Mouse
specificity :
Detects human and mouse BMPR-IB/ALK-6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross-reactivity with recombinant mouse (rm) BMPR-IB and no cross-reactivity with recombinant human (rh) BMPR-IA, rmBMPR-IA, or rhBMPR-II is observed.
gene symbol :
BMPR1B
accessionNumbers :
O00238
applications :
ELISA Development,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry
USD :
469 USD
alt names :
activin receptor-like kinase 6, ALK-6, ALK6CDw293, BMP type-1B receptor, BMPR1B, BMPR-1B, BMPRIB, bone morphogenetic protein receptor type-1B, bone morphogenetic protein receptor, type IB, CDw293, CDw293 antigen, EC 2.7.11, EC 2.7.11.30, serine/threonine receptor kinase
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.