Mouse IL-12/IL-23 p40 Antibody | R&D Systems MAB4991-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse IL-12/IL-23 p40 Antibody

catalog :

MAB4991-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

459 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

C17.8

reactivity :

human, mouse

application :

western blot, ELISA, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 9

Reference
Hong S, Kim J, Lee S, Shin J, Choi H, Lee E, et al. Transgenic viral expression of PH-20, IL-12, and sPD1-Fc enhances immune cell infiltration and anti-tumor efficacy of an oncolytic virus. Mol Ther Oncolytics. 2023;30:301-315 pubmed publisher
Chen Y, Chauhan S, Shao C, Omoto M, Inomata T, Dana R. IFN-?-Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity. J Immunol. 2017;199:1163-1169 pubmed publisher
Ohama H, Asai A, Ito I, Suzuki S, Kobayashi M, Higuchi K, et al. M2b macrophage elimination and improved resistance of mice with chronic alcohol consumption to opportunistic infections. Am J Pathol. 2015;185:420-31 pubmed publisher
Depaolo R, Abadie V, Tang F, Fehlner Peach H, Hall J, Wang W, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011;471:220-4 pubmed publisher
Bourgeois E, Van L, Samson M, Diem S, Barra A, Roga S, et al. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production. Eur J Immunol. 2009;39:1046-55 pubmed publisher
Yamamoto M, Kikuchi H, Ohta M, Kawabata T, Hiramatsu Y, Kondo K, et al. TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res. 2008;68:9754-62 pubmed publisher
An H, Jeong H, Um J, Kim H, Hong S. Glechoma hederacea inhibits inflammatory mediator release in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. J Ethnopharmacol. 2006;106:418-24 pubmed
Bengtsson A, Ryan E, Giordano D, Magaletti D, Clark E. 17beta-estradiol (E2) modulates cytokine and chemokine expression in human monocyte-derived dendritic cells. Blood. 2004;104:1404-10 pubmed
Oppmann B, Lesley R, Blom B, Timans J, Xu Y, Hunte B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13:715-25 pubmed

product information

master code :

MAB4991

SKU :

MAB4991-100

product name :

Mouse IL-12/IL-23 p40 Antibody

unit size :

100 ug (also 500 ug, 25 ug)

description :

The Mouse IL-12/IL-23 p40 Antibody from R&D Systems is a rat monoclonal antibody to IL-12/IL-23 p40. This antibody reacts with human,mouse. The Mouse IL-12/IL-23 p40 Antibody has been validated for the following applications: ELISA Development,Flow Cytometry,Neutralization,Functional Assay,In vivo assay,Western Blot,ELISA Capture (Matched Antibody Pair).

target :

IL-12/IL-23 p40

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

C17.8

conjugate :

Unconjugated

host :

Rat

immunogen :

Recombinant mouse IL-12 p70 heterodimer

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects the mouse IL-12/IL-23 p40 subunit. Polymorphisms exist in the mouse p40 sequences [Ymer, S. et al . (2002) Genes and Immunity 3 :151.].

gene symbol :

Il12b

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Cell Proliferation Induced by IL-12 and Neutralization by Mouse IL-12/IL-23 p40 Antibody.

applications :

ELISA Development,Flow Cytometry,Neutralization,Functional Assay,In vivo assay,Western Blot,ELISA Capture (Matched Antibody Pair)

USD :

459 USD

alt names :

CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL12 p40, IL-12 subunit p40, IL12B, IL-12B, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2, NKSF2IL12, subunit p40

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage