Mouse IL-12/IL-23 p40 Antibody | R&D Systems MAB499-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse IL-12/IL-23 p40 Antibody

catalog :

MAB499-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

419 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

30517

reactivity :

human, mouse

application :

ELISA, neutralization, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 3

Reference
SchrÃ¶der J, Moll J, Baran P, GrÃ¶tzinger J, Scheller J, Floss D. Non-canonical interleukin 23 receptor complex assembly: p40 protein recruits interleukin 12 receptor Î²1 via site II and induces p19/interleukin 23 receptor interaction via site III. J Biol Chem. 2015;290:359-70 pubmed publisher
Smith E, Zarbock A, Stark M, Burcin T, Bruce A, Foley P, et al. IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice. J Immunol. 2007;179:8274-9 pubmed
Lukacs N, Berlin A, Schols D, Skerlj R, Bridger G. AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity. Am J Pathol. 2002;160:1353-60 pubmed

product information

master code :

MAB499

SKU :

MAB499-100

product name :

Mouse IL-12/IL-23 p40 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse IL-12/IL-23 p40 Antibody from R&D Systems is a rat monoclonal antibody to IL-12/IL-23 p40. This antibody reacts with mouse,primate - chlorocebus aethiops (african green monkey). The Mouse IL-12/IL-23 p40 Antibody has been validated for the following applications: ELISA Development,Immunoprecipitation,Neutralization,ELISA Capture (Matched Antibody Pair).

target :

IL-12/IL-23 p40

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

30517

conjugate :

Unconjugated

host :

Rat

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse IL-12 p40

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse,Primate - Chlorocebus aethiops (African Green Monkey)

specificity :

Detects mouse IL-12 p40 in ELISAs. Polymorphisms exist in the mouse IL-12 p40 sequence. This antibody recognizes an allelic epitope found in the p40 subunit of several mouse strains including BALB/c, C57BL/6, CBA, C3H, DBA/1, NOR, I29/J, and A.SW. This antibody does not recognize the allelic variant that occurs in strains AKR, DBA/2, NOD, NZB, NZC, NZO, NZW, or SJL (1). In ELISAs, this antibody shows 100% cross-reactivity with recombinant mouse (rm) IL-23, 30% cross-reactivity with rmIL-12 p70, and no cross-reactivity with recombinant human (rh) IL-12 p70 or rhIL-12 p40.

gene symbol :

Il12b

applications :

ELISA Development,Immunoprecipitation,Neutralization,ELISA Capture (Matched Antibody Pair)

USD :

419 USD

alt names :

CLMF, CLMF p40, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL12 p40, IL-12 subunit p40, IL12B, IL-12B, IL-12BNK cell stimulatory factor chain 2, interleukin 12, p40, interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocytematuration factor 2, p40), interleukin-12 beta chain, interleukin-12 subunit beta, natural killer cell stimulatory factor, 40 kD subunit, NKSF, NKSF2, NKSF2IL12, subunit p40

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage