CCL2/JE/MCP-1 Antibody | R&D Systems MAB479-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

CCL2/JE/MCP-1 Antibody

catalog :

MAB479-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

469 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

123616

reactivity :

human, mouse

application :

western blot, immunohistochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 24

Reference
Namangkalakul W, Nagai S, Jin C, Nakahama K, Yoshimoto Y, Ueha S, et al. Augmented effect of fibroblast growth factor 18 in bone morphogenetic protein 2-induced calvarial bone healing by activation of CCL2/CCR2 axis on M2 macrophage polarization. J Tissue Eng. 2023;14:20417314231187960 pubmed publisher
Wang L, Lan J, Tang J, Luo N. MCP-1 targeting: Shutting off an engine for tumor development. Oncol Lett. 2022;23:26 pubmed publisher
Li X, Yuan B, Lu M, Wang Y, Ding N, Liu C, et al. The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression. Nat Commun. 2021;12:7213 pubmed publisher
Lees D, Reynolds L, Pedrosa A, Roy Luzarraga M, Hodivala Dilke K. Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression. Angiogenesis. 2021;24:471-482 pubmed publisher
Villarreal Ponce A, Tiruneh M, Lee J, Guerrero Juarez C, Kuhn J, David J, et al. Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair. Cell Rep. 2020;33:108417 pubmed publisher
Li L, Ni L, Heary R, Elkabes S. Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury. J Neuroinflammation. 2020;17:73 pubmed publisher
Salah S, Meisenheimer J, Rao R, Peda J, Wallace D, Foster D, et al. MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease. Am J Physiol Renal Physiol. 2019;317:F343-F360 pubmed publisher
Jenkins R, Aref A, Lizotte P, Ivanova E, Stinson S, Zhou C, et al. Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids. Cancer Discov. 2018;8:196-215 pubmed publisher
Steinberg S, Shabaneh T, Zhang P, Martyanov V, Li Z, Malik B, et al. Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors. Cancer Res. 2017;77:1599-1610 pubmed publisher
Rothhammer V, Mascanfroni I, Bunse L, Takenaka M, Kenison J, Mayo L, et al. Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor. Nat Med. 2016;22:586-97 pubmed publisher
He S, He S, Chen C, Deborde S, Bakst R, Chernichenko N, et al. The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion. Mol Cancer Res. 2015;13:380-90 pubmed publisher
Kowalewska P, Patrick A, Fox Robichaud A. Syndecan-1 in the mouse parietal peritoneum microcirculation in inflammation. PLoS ONE. 2014;9:e104537 pubmed publisher
Glista Baker E, Taylor A, Sayers B, Thompson E, Bonner J. Nickel nanoparticles cause exaggerated lung and airway remodeling in mice lacking the T-box transcription factor, TBX21 (T-bet). Part Fibre Toxicol. 2014;11:7 pubmed publisher
Kashiwagi S, Yuan J, Forbes B, Hibert M, Lee E, Whicher L, et al. Near-infrared laser adjuvant for influenza vaccine. PLoS ONE. 2013;8:e82899 pubmed publisher
Scalfone L, Nel H, Gagliardo L, Cameron J, Al Shokri S, Leifer C, et al. Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis. Infect Immun. 2013;81:1354-63 pubmed publisher
Roy R, Wuthrich M, Klein B. Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J Immunol. 2012;189:2545-52 pubmed publisher
Uchida Y, Takeshita K, Yamamoto K, Kikuchi R, Nakayama T, Nomura M, et al. Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1. Diabetes. 2012;61:1552-61 pubmed publisher
Liu J, Jha P, Lyzogubov V, Tytarenko R, Bora N, Bora P. Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization. J Biol Chem. 2011;286:20991-1001 pubmed publisher
Venet F, Huang X, Chung C, Chen Y, Ayala A. Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. Am J Pathol. 2010;176:764-73 pubmed publisher
Narasaraju T, Ng H, Phoon M, Chow V. MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis. Am J Respir Cell Mol Biol. 2010;42:732-43 pubmed publisher
Wang T, Dai H, Wan N, Moore Y, Dai Z. The role for monocyte chemoattractant protein-1 in the generation and function of memory CD8+ T cells. J Immunol. 2008;180:2886-93 pubmed
Itaya M, Sakurai E, Nozaki M, Yamada K, Yamasaki S, Asai K, et al. Upregulation of VEGF in murine retina via monocyte recruitment after retinal scatter laser photocoagulation. Invest Ophthalmol Vis Sci. 2007;48:5677-83 pubmed
Stamatovic S, Keep R, Mostarica Stojkovic M, Andjelkovic A. CCL2 regulates angiogenesis via activation of Ets-1 transcription factor. J Immunol. 2006;177:2651-61 pubmed
Penido C, Vieira de Abreu A, Bozza M, Castro Faria Neto H, Bozza P. Role of monocyte chemotactic protein-1/CC chemokine ligand 2 on gamma delta T lymphocyte trafficking during inflammation induced by lipopolysaccharide or Mycobacterium bovis bacille Calmette-Guérin. J Immunol. 2003;171:6788-94 pubmed

image

image 1 :

Chemotaxis Induced by CCL2/JE and Neutralization by Mouse CCL2/JE Antibody.

product information

brand :

R&D Systems, a Bio-Techne brand

catalog number base :

MAB479

SKU :

MAB479-100

product name :

CCL2/JE/MCP-1 Antibody

description :

The Mouse CCL2/JE/MCP-1 Antibody from R&D Systems is a rat monoclonal antibody to CCL2/JE/MCP-1. This antibody reacts with human,mouse,transgenic mouse. The Mouse CCL2/JE/MCP-1 Antibody has been validated for the following applications: Bioassay,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,In vivo assay,Neutralization.

target :

CCL2/JE/MCP-1

unit size :

100 ug (also 25 ug, 500 ug)

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

123616

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse CCL2/JE/MCP-1, Gln24-Arg96, Accession # P10148

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects mouse CCL2/JE/MCP-1 in ELISAs. Does not cross-react with recombinant human (rh) CCL1, 2, 3, 4, 5, 7, 8, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, rmCCL1, 3, 4, 5, 6, 7, 9/10/MIP-1 gamma , 11, 12, 17, 19, 20, 21, 22, 24, 25, 27, 28, or rrCCL20.

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

gene symbol :

Ccl2

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

accessionNumbers :

P10148

applications :

Bioassay,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,In vivo assay,Neutralization

product keywords :

MAB479, mCCL2/JE MAb Cl 123616, Rat Anti-Mouse CCL2/JE/MCP-1 Monoclonal Antibody, Anti-CCL2, Anti-JE, Anti-MCP-1, Rat Anti Mouse CCL2/JE/MCP-1 Monoclonal Antibody, Anti-mCCL2, MCP1, CCL 2, Chemokines, Chemokine, cytokine, cytokines, C-C Motif Chemokine Ligand 2, Monocyte Chemotactic And Activating Factor, Monocyte Secretory Protein JE, Small Inducible Cytokine Subfamily A (Cys-Cys), Member 2, Monocyte Chemoattractant Protein-1,

USD :

459

USD 2025 :

469 USD

alt names :

C-C motif chemokine ligand 2, CCL2, GDCF-2, HC11, HSMCR30, MCAF, Mcp1, MCP-1, SCYA2, SMC-CF

more info or order :

R&D Systems product webpage