Mouse CCL5/RANTES Antibody | R&D Systems MAB478-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CCL5/RANTES Antibody

catalog :

MAB478-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

53405

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 30

Reference
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Chi G, Lu J, He T, Wang Y, Zhou X, Zhang Y, et al. High mobility group box-1 protein promotes astrocytic CCL5 production through the MAPK/NF-κB pathway following spinal cord injury. Sci Rep. 2024;14:22344 pubmed publisher
B xe9 nard A, Mittelst xe4 dt A, Kl xf6 sch B, Glanz K, M xfc ller J, Schoen J, et al. IL-3 orchestrates ulcerative colitis pathogenesis by controlling the development and the recruitment of splenic reservoir neutrophils. Cell Rep. 2023;42:112637 pubmed publisher
Tang T, Huang X, Lu M, Zhang G, Han X, Liang T. Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner. Nat Commun. 2023;14:3364 pubmed publisher
Wu Z, Thierry K, Bachy S, Zhang X, Gamradt P, Hernandez Vargas H, et al. Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer. EMBO Rep. 2023;24:e56524 pubmed publisher
Liu J, Liang X, Li M, Lin F, Ma X, Xin Y, et al. Intramyocardial injected human umbilical cord-derived mesenchymal stem cells (HucMSCs) contribute to the recovery of cardiac function and the migration of CD4+ T cells into the infarcted heart via CCL5/CCR5 signaling. Stem Cell Res Ther. 2022;13:247 pubmed publisher
Jiang K, Zhang Q, Fan Y, Li J, Zhang J, Wang W, et al. MYC inhibition reprograms tumor immune microenvironment by recruiting T lymphocytes and activating the CD40/CD40L system in osteosarcoma. Cell Death Discov. 2022;8:117 pubmed publisher
de Andrade Costa A, Chatterjee J, Cobb O, Cordell E, Chao A, Schaeffer S, et al. Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation. Neurooncol Adv. 2022;4:vdab194 pubmed publisher
Zhao N, Dang H, Ma L, Martin S, Forgues M, Ylaya K, et al. Intratumoral γδ T-Cell Infiltrates, Chemokine (C-C Motif) Ligand 4/Chemokine (C-C Motif) Ligand 5 Protein Expression and Survival in Patients With Hepatocellular Carcinoma. Hepatology. 2021;73:1045-1060 pubmed publisher
Seo W, Shimizu K, Kojo S, Okeke A, Kohwi Shigematsu T, Fujii S, et al. Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity. Nat Commun. 2020;11:1562 pubmed publisher
Fortier M, Cadoux M, Boussetta N, Pham S, Donné R, Couty J, et al. Hepatospecific ablation of p38α MAPK governs liver regeneration through modulation of inflammatory response to CCl4-induced acute injury. Sci Rep. 2019;9:14614 pubmed publisher
Verma A, Waghmare T, Jachak G, Philkhana S, Reddy D, Basu A. Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NFκb inactivation in microglia. PLoS Negl Trop Dis. 2018;12:e0006648 pubmed publisher
Böttcher J, Bonavita E, Chakravarty P, Blees H, Cabeza Cabrerizo M, Sammicheli S, et al. NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control. Cell. 2018;172:1022-1037.e14 pubmed publisher
Lee J, Hoshino A, Inoue K, Saitou T, Uehara S, Kobayashi Y, et al. The HIV co-receptor CCR5 regulates osteoclast function. Nat Commun. 2017;8:2226 pubmed publisher
Aswad M, Assi S, Schif Zuck S, Ariel A. CCL5 Promotes Resolution-Phase Macrophage Reprogramming in Concert with the Atypical Chemokine Receptor D6 and Apoptotic Polymorphonuclear Cells. J Immunol. 2017;199:1393-1404 pubmed publisher
Zhang X, Zheng Z, Liu X, Shu B, Mao P, Bai B, et al. Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway. J Neuroinflammation. 2016;13:209 pubmed publisher
Koh M, Gagea M, Sargis T, Lemos R, Grandjean G, Charbono A, et al. A new HIF-1Î±/RANTES-driven pathway to hepatocellular carcinoma mediated by germline haploinsufficiency of SART1/HAF in mice. Hepatology. 2016;63:1576-91 pubmed publisher
Mikucki M, Fisher D, Matsuzaki J, Skitzki J, Gaulin N, Muhitch J, et al. Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat Commun. 2015;6:7458 pubmed publisher
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Arnaud C, Beguin P, Lantuejoul S, Pepin J, Guillermet C, Pelli G, et al. The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition. Am J Respir Crit Care Med. 2011;184:724-31 pubmed publisher
Stubblefield Park S, Widness M, Levine A, Patterson C. T cell-, interleukin-12-, and gamma interferon-driven viral clearance in measles virus-infected brain tissue. J Virol. 2011;85:3664-76 pubmed publisher
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product information

master code :

MAB478

SKU :

MAB478-100

product name :

Mouse CCL5/RANTES Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse CCL5/RANTES Antibody from R&D Systems is a rat monoclonal antibody to CCL5/RANTES. This antibody reacts with human,mouse,rat. The Mouse CCL5/RANTES Antibody has been validated for the following applications: Neutralization,Immunohistochemistry,In vivo assay,Bioassay,ELISA Development,ELISA Development (Capture),Immunohistochemistry-Frozen,Immunocytochemistry.

target :

CCL5/RANTES

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

53405

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse CCL5/RANTES, Ser24-Ser91, Accession # P30882

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Rat

specificity :

Detects mouse CCL5/RANTES in direct ELISAs. Shows 50% cross-reactivity with recombinant human (rh) CCL5, and no cross-reactivity with recombinant feline CCL5, rhCCL3, recombinant mouse (rm) CCL3, rmCCL4, rhCCL4, rhCCL14, or rhCCL18.

gene symbol :

CCL5

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

CCL5/RANTES antibody in Mouse Splenocytes by Immunocytochemistry (ICC).

accessionNumbers :

P30882

applications :

Neutralization,Immunohistochemistry,In vivo assay,Bioassay,ELISA Development,ELISA Development (Capture),Immunohistochemistry-Frozen,Immunocytochemistry

USD :

489 USD

alt names :

chemokine (C-C motif) ligand 5, D17S136Enormally T-expressed, and presumably secreted, EoCP, Eosinophil chemotactic cytokine, RANTES, SISd, SIS-delta, small inducible cytokine A5 (RANTES), small inducible cytokine subfamily A (Cys-Cys), member 5, Small-inducible cytokine A5, T cell-specific protein P228, T-cell specific protein p288, TCP228T-cell-specific protein RANTES

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage