Mouse Sonic Hedgehog/Shh N-Terminus Antibody | R&D Systems MAB4641-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Sonic Hedgehog/Shh N-Terminus Antibody

catalog :

MAB4641-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

459 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

171018

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 7

Reference
Tape C, Ling S, Dimitriadi M, McMahon K, Worboys J, Leong H, et al. Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. Cell. 2016;165:910-20 pubmed publisher
Kim W, Lee S, Kim K. Sonic hedgehog secreted by neurons regulates angiopoietin expression in neighboring fibroblasts. Int J Mol Med. 2014;34:213-8 pubmed publisher
Engevik A, Feng R, Yang L, Zavros Y. The acid-secreting parietal cell as an endocrine source of Sonic Hedgehog during gastric repair. Endocrinology. 2013;154:4627-39 pubmed publisher
Delloye Bourgeois C, Gibert B, Rama N, Delcros J, Gadot N, Scoazec J, et al. Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity. PLoS Biol. 2013;11:e1001623 pubmed publisher
El Zaatari M, Daignault S, Tessier A, Kelsey G, Travnikar L, Cantu E, et al. Plasma Shh levels reduced in pancreatic cancer patients. Pancreas. 2012;41:1019-28 pubmed publisher
Nakamura K, Sasajima J, Mizukami Y, Sugiyama Y, Yamazaki M, Fujii R, et al. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS ONE. 2010;5:e8824 pubmed publisher
Mfopou J, De Groote V, Xu X, Heimberg H, Bouwens L. Sonic hedgehog and other soluble factors from differentiating embryoid bodies inhibit pancreas development. Stem Cells. 2007;25:1156-65 pubmed

product information

master code :

MAB4641

SKU :

MAB4641-100

product name :

Mouse Sonic Hedgehog/Shh N-Terminus Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Mouse Sonic Hedgehog/Shh N-Terminus Antibody from R&D Systems is a rat monoclonal antibody to Sonic Hedgehog/Shh. This antibody reacts with human,mouse. The Mouse Sonic Hedgehog/Shh N-Terminus Antibody has been validated for the following applications: ELISA Capture,ELISA Development,Neutralization,Immunohistochemistry,Western Blot,ELISA Capture (Matched Antibody Pair).

target :

Sonic Hedgehog/Shh

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

171018

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse Sonic Hedgehog, Cys25-Gly198 (Lys122Arg), Accession # Q62226

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse Sonic Hedgehog in ELISAs. In Western blots, approximately 50% cross-reactivity with recombinant mouse (rm) Dhh (N-terminus; aa 23-198) is observed and no cross-reactivity with rmIhh (N-terminus; aa 66-240), rmDhh (C-terminus; aa 199-396), or rmShh (C-terminus; aa 199-437) is observed.

gene symbol :

SHH

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Alkaline Phosphatase Production Induced by Sonic Hedgehog and Neutralization by Mouse Sonic Hedgehog Antibody.

accessionNumbers :

Q62226

applications :

ELISA Capture,ELISA Development,Neutralization,Immunohistochemistry,Western Blot,ELISA Capture (Matched Antibody Pair)

USD :

459 USD

alt names :

HHG1, HHG-1, HLP3, HPE3, MCOPCB5, MCOPCB5sonic hedgehog (Drosophila) homolog, Shh, ShhNC, SMMCI, SMMCIsonic hedgehog homolog (Drosophila), sonic hedgehog, sonic hedgehog homolog, sonic hedgehog protein, TPT, TPTPS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage