Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody | R&D Systems MAB453 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody

catalog :

MAB453

quantity :

100 ug (also 25 ug, 500 ug)

price :

369 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

48415

reactivity :

human, mouse

application :

western blot, ELISA, neutralization, flow cytometry

citations: 44

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; fig 7d	Finsterbusch M, Hall P, Li A, Devi S, Westhorpe C, Kitching A, et al. Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus. Proc Natl Acad Sci U S A. 2016;113:E5172-81 pubmed publisher
	Shin J, Kwon M, Hwang J, Lee S, Lee J, Kim H, et al. Keratinocyte transglutaminase 2 promotes CCR6+ γδT-cell recruitment by upregulating CCL20 in psoriatic inflammation. Cell Death Dis. 2020;11:301 pubmed publisher
	Owen Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum A, et al. Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. J Clin Invest. 2020;130:2301-2318 pubmed publisher
	Chen L, Gu J, Qian Y, Li M, Qian Y, Xu M, et al. Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity. Cell Mol Gastroenterol Hepatol. 2019;7:623-639 pubmed publisher
	Kulkarni U, Zemans R, Smith C, Wood S, Deng J, Goldstein D. Excessive neutrophil levels in the lung underlie the age-associated increase in influenza mortality. Mucosal Immunol. 2019;12:545-554 pubmed publisher
	Andonegui G, Zelinski E, Schubert C, Knight D, Craig L, Winston B, et al. Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment. JCI Insight. 2018;3: pubmed publisher
	Hornick E, Banoth B, Miller A, Zacharias Z, Jain N, Wilson M, et al. Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. J Immunol. 2018;200:1188-1197 pubmed publisher
	Lv R, Zhao J, Lei M, Xiao D, Yu Y, Xie J. IL-33 Attenuates Sepsis by Inhibiting IL-17 Receptor Signaling through Upregulation of SOCS3. Cell Physiol Biochem. 2017;42:1961-1972 pubmed publisher
	Farmaki E, Kaza V, Papavassiliou A, Chatzistamou I, Kiaris H. Induction of the MCP chemokine cluster cascade in the periphery by cancer cell-derived Ccl3. Cancer Lett. 2017;389:49-58 pubmed publisher
	Busch C, Hendrikx T, Weismann D, Jäckel S, Walenbergh S, Rendeiro A, et al. Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology. 2017;65:1181-1195 pubmed publisher
	Kouwenberg M, Jacobs C, van der Vlag J, Hilbrands L. Allostimulatory Effects of Dendritic Cells with Characteristic Features of a Regulatory Phenotype. PLoS ONE. 2016;11:e0159986 pubmed publisher
	Lazzarini E, Balbi C, Altieri P, Pfeffer U, Gambini E, Canepa M, et al. The human amniotic fluid stem cell secretome effectively counteracts doxorubicin-induced cardiotoxicity. Sci Rep. 2016;6:29994 pubmed publisher
	Seifert L, Werba G, Tiwari S, Giao Ly N, Alothman S, Alqunaibit D, et al. The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression. Nature. 2016;532:245-9 pubmed publisher
	Denney L, Byrne A, Shea T, Buckley J, Pease J, Herledan G, et al. Pulmonary Epithelial Cell-Derived Cytokine TGF-Î²1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function. Immunity. 2015;43:945-58 pubmed publisher
	Lochhead R, Ma Y, Zachary J, Baltimore D, Zhao J, Weis J, et al. MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. PLoS Pathog. 2014;10:e1004212 pubmed publisher
	West D, Del Rosso C, Yin X, Stuart P. CXCL1 but not IL-6 is required for recurrent herpetic stromal keratitis. J Immunol. 2014;192:1762-7 pubmed publisher
	Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, et al. G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis. J Immunol. 2013;190:5329-36 pubmed publisher
	Junkins R, MacNeil A, Wu Z, McCormick C, Lin T. Regulator of calcineurin 1 suppresses inflammation during respiratory tract infections. J Immunol. 2013;190:5178-86 pubmed publisher
	Zhang M, Yin L, Zhang K, Sun W, Yang S, Zhang B, et al. Response patterns of cytokines/chemokines in two murine strains after irradiation. Cytokine. 2012;58:169-77 pubmed publisher
	Roy M, Richard J, Dumas A, Vallières L. CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis. J Neuroinflammation. 2012;9:18 pubmed publisher
	Cheung R, Shen F, Phillips J, McGeachy M, Cua D, Heyworth P, et al. Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest. 2011;121:4446-61 pubmed publisher
	Kim J, Natarajan S, Vaickus L, Bouchard J, Beal D, Cruikshank W, et al. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011;179:2730-9 pubmed publisher
	Summers S, van der Veen B, O Sullivan K, Gan P, Ooi J, Heeringa P, et al. Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis. Kidney Int. 2010;78:1263-74 pubmed publisher
	Chou R, Kim N, Sadik C, Seung E, Lan Y, Byrne M, et al. Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis. Immunity. 2010;33:266-78 pubmed publisher
	Lemos H, Grespan R, Vieira S, Cunha T, Verri W, Fernandes K, et al. Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A. 2009;106:5954-9 pubmed publisher
	Wieland C, van der Windt G, Florquin S, McKenzie A, van der Poll T. ST2 deficient mice display a normal host defense against pulmonary infection with Mycobacterium tuberculosis. Microbes Infect. 2009;11:524-30 pubmed publisher
	Maione F, Paschalidis N, Mascolo N, Dufton N, Perretti M, D Acquisto F. Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol. 2009;77:878-87 pubmed publisher
	Wieland C, van der Windt G, Wiersinga W, Florquin S, van der Poll T. CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis. Immunology. 2008;125:272-9 pubmed publisher
	De Filippo K, Henderson R, Laschinger M, Hogg N. Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways. J Immunol. 2008;180:4308-15 pubmed
	Scortegagna M, Cataisson C, Martin R, Hicklin D, Schreiber R, Yuspa S, et al. HIF-1alpha regulates epithelial inflammation by cell autonomous NFkappaB activation and paracrine stromal remodeling. Blood. 2008;111:3343-54 pubmed publisher
	Wengner A, Pitchford S, Furze R, Rankin S. The coordinated action of G-CSF and ELR + CXC chemokines in neutrophil mobilization during acute inflammation. Blood. 2008;111:42-9 pubmed
	Carlson E, Lin M, Liu C, Kao W, Perez V, Pearlman E. Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. J Biol Chem. 2007;282:35502-9 pubmed
	Cunha T, Verri W, Fukada S, Guerrero A, Santodomingo Garzon T, Poole S, et al. TNF-alpha and IL-1beta mediate inflammatory hypernociception in mice triggered by B1 but not B2 kinin receptor. Eur J Pharmacol. 2007;573:221-9 pubmed
	Watanabe H, Kubo M, Numata K, Takagi K, Mizuta H, Okada S, et al. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J Immunol. 2006;177:8650-7 pubmed
	Penido C, Conte F, Chagas M, Rodrigues C, Pereira J, Henriques M. Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice. Inflamm Res. 2006;55:457-64 pubmed
	Hajjar A, Harvey M, Shaffer S, Goodlett D, Sjostedt A, Edebro H, et al. Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors. Infect Immun. 2006;74:6730-8 pubmed
	Ramos C, Fernandes K, Canetti C, Teixeira M, Silva J, Cunha F. Neutrophil recruitment in immunized mice depends on MIP-2 inducing the sequential release of MIP-1alpha, TNF-alpha and LTB(4). Eur J Immunol. 2006;36:2025-34 pubmed
	Osuchowski M, Welch K, Siddiqui J, Remick D. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J Immunol. 2006;177:1967-74 pubmed
	Gao H, Hoesel L, Guo R, Rancilio N, Sarma J, Ward P. Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury. J Immunol. 2006;177:612-20 pubmed
	Gueders M, Balbin M, Rocks N, Foidart J, Gosset P, Louis R, et al. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol. 2005;175:2589-97 pubmed
	Osuchowski M, Siddiqui J, Copeland S, Remick D. Sequential ELISA to profile multiple cytokines from small volumes. J Immunol Methods. 2005;302:172-81 pubmed
	Ellaban E, Bolgos G, Remick D. Selective macrophage suppression during sepsis. Cell Immunol. 2004;231:103-11 pubmed
	Guo R, Lentsch A, Warner R, Huber Lang M, Sarma J, Hlaing T, et al. Regulatory effects of eotaxin on acute lung inflammatory injury. J Immunol. 2001;166:5208-18 pubmed
	Knott P, Gater P, Dunford P, Fuentes M, Bertrand C. Rapid up-regulation of CXC chemokines in the airways after Ag-specific CD4+ T cell activation. J Immunol. 2001;166:1233-40 pubmed

product information

brand :

R&D Systems

master code :

MAB453

SKU :

MAB453-100

product name :

Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody

description :

The Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody from R&D Systems is a rat monoclonal antibody to CXCL1/GRO alpha/KC/CINC-1. This antibody reacts with mouse. The Mouse CXCL1/GRO alpha/KC/CINC-1 Antibody has been validated for the following applications: Western Blot, Neutralization, ELISA Capture (Matched Antibody Pair).

target :

CXCL1/GRO alpha/KC/CINC-1

category :

Primary Antibodies

unit size :

100 ug (also 25 ug, 500 ug)

buffer :

Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.

clonality :

Monoclonal

clone :

48415

conjugate :

Unconjugated

host :

Rat

immunogen :

E. coli -derived recombinant mouse CXCL1/GRO alpha/KC/CINC-1, Arg20-Lys96, Accession # P12850

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Mouse

specificity :

Detects mouse CXCL1/GRO alpha/KC/CINC-1 in direct ELISAs and Western blots. Shows 100% cross-reactivity with recombinant human (rh) CXCL2, less than 40% cross-reactivity with recombinant rat (rr) CINC-1, and no cross-reactivity with rrCINC-3, rhCXCL3, rhCXCL5, rhCXCL6, or recombinant mouse CXCL6.

gene symbol :

Cxcl1

endotoxin note :

<0.10 EU per 1 µg of the antibody by the LAL method.

catalog number base :

MAB453

accessionNumbers :

P12850

applications :

Western Blot, Neutralization, ELISA Capture (Matched Antibody Pair)

2020 USD :

339

2021 USD :

369 USD

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.